Ranitidine-hydrochloride _Histamine Receptor Antagonist - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERanitidine hydrochlorideCat. No.: HY-B0281ACAS No.: 66357-59-3分式: CHClNOS分量: 350.86作靶点: Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-

2、20C 1 month溶解性数据体外实验 H2O : 50 mg/mL (142.51 mM)DMSO : 50 mg/mL (142.51 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.8501 mL 14.2507 mL 28.5014 mL5 mM 0.5700 mL 2.8501 mL 5.7003 mL10 mM 0.2850 mL 1.4251 mL 2.8501 mL请根据产品在不同溶剂中的溶解度，选择

3、合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.13 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in sa

4、line)1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (7.13 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (7.13 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Ranitidine hydrochloride是组胺H2-受体拮抗剂，IC50为3.3uM。REFERENCES1. Herling, A.W., et al., Inhibition

5、of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760(TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9.2. Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug MetabolDrug Interact, 2004. 20(4): p. 273-81.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02