IDO-IN-6-NLG-1486-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIDO-IN-6Cat. No.: HY-18770ACAS No.: 1402837-76-6Synonyms: NLG-1486分式: CHFNO分量: 316.37作靶点: Indoleamine 2,3-Dioxygenase (IDO)作通路: Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据

2、体外实验 DMSO : 50 mg/mL (158.04 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 3.1609 mL 15.8043 mL 31.6086 mL5 mM 0.6322 mL 3.1609 mL 6.3217 mL10 mM 0.3161 mL 1.5804 mL 3.1609 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果

3、的可靠性，体内实验的作液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (7.90 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (7.90 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% cor

4、n oil1/2 Master of Small Molecules 您边的抑制剂师www.MedChemESolubility: 2.5 mg/mL (7.90 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 IDO-IN-6 (NLG-1486)种哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50 值 1 M，详细信息请参考专利献WO2012142237A1 中的化合物 1486。IC50 & Target IDO1 M (IC50)体外研究 IDO-IN-6 (Compound 1486) is an indoleamine 2,3-dioxygen

5、ase (IDO) inhibitor with an IC50 of 1.REFERENCES1. Mautino, et al. Preparation of fused imidazole derivatives as IDO inhibitors. From PCT Int. Appl. (2012), 20121018.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589559