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1、神經傳導介質抑制類胜肽(Neurotransmitter-inhibiting peptides)acetyl-glutamyl-glutamyl-methyoxylglutaminyl-arginyl-arginylamide (Argireline)在細胞外藉由影響鈣離子調控的胞吐作用(Calcium-dependent exocytosis)所需的蛋白質生成,進而抑制神經介質的釋放。藉由減少肌肉收縮而減少細紋和皺紋SNARE complex 是膜上蛋白質調控神經胞吐作用的核心,因為此一複合物會導致(Catecholamine)的釋放,如果Catecholamine釋放太多就會導致皺紋以及

2、細紋的形成;所以此類的胜肽就是抑制SNARE complex 生成 生長因子 Growth FactorEGF : Epidermal Growth Factor表皮細胞生長因子刺激老化皮膚細胞再活化刺激表皮細胞生長 刺激其他活細胞激素分泌刺激纖維母細胞分泌膠原蛋白及彈力蛋白刺激受傷組織血管增生,加速癒合傷口癒合過程中防止疤痕形成抗皺FGF: Fibroblast Growth Factor纖維母細胞生長因子皮膚再生刺激膠原蛋白及彈力蛋白合成刺激纖維母細胞生長刺激老化組織再生以及傷口癒合刺激表皮細胞生長及移動刺激毛髮生長,防止白頭髮形成刺激玻尿酸合成IGF: Insulin like Grow

3、th Factor類胰島素生長因子扮演與生長荷爾蒙相同功能刺激骨骼、肌肉及神經再生刺激受傷組織血管增生減緩腦下垂體老化刺激玻尿酸合成刺激毛髮生長並預防落髮VEGF : Vascular Endothelial Growth Factor血管內皮細胞生長因子血管內皮細胞生長因子是強力新血管生長因子刺激血管細胞增生刺激血管細胞移動TGF-3 : Transforming Growth Factor-3多功能的細胞激素刺激細胞繁殖、生長及分化去除疤痕的形成協助傷口癒合化粧品的奈米科技風潮 奈米結構易滲透至皮膚內層,讓化妝品的效果再也不侷限在單純的表面功夫 奈米載體可使其成分滲透至真皮層與角質層交界處

4、,對需要深層吸收才得以發揮的美白、防皺與塑身等功能,可以得到更有效的發揮 化粧品與奈米科技奈米化原料粒子 NanoparticleTitanium dioxide、Zinc oxide、Iron oxideMica and other metal oxide奈米容器載體 NanocarrierLiposome and ethosomeNanosome and micelleFullerene奈米化纖維材料NanofiberMask containing chitin/chitosan fiberHappiLindsay Elkins, Contributing Editor, December

5、 2008Age gracefully? Not todays consumer, who often seeks anti-aging advice from her dermatologist who, more often than ever these days, markets his or her own line of products.Sales of professional skin care products rose 13% in 2007, with anti-aging products leading the category. The International

6、 Top 30 20081. UnileverUnited Kingdom$25.48 billion2. LOralFrance$23.3 billion3. HenkelGermany$9.75 billion4. KaoJapan$9.6 billion5. Reckitt BenckiserUnited Kingdom$9.42 billion6. BeiersdorfGermany$6.38 billion7. ShiseidoJapan$6.35 billion8. LVMHFrance$3.74 billion9. LionJapan$2.65 billion10. Chanel

7、France$2.5 billion11. Yves RocherFrance$2.41 billion12. NaturaBrazil$2.2 billion13. GlaxoSmithKlineUnited Kingdom$2.1 billion14. AmorePacificKorea$1.78 billion15. KosJapan$1.58 billionThe International Top 30 200816. ClarinsFrance$1.38 billion17. OriflameSweden$1.37 billion18. LGKorea$1.26 billion19

8、. PuigSpain$1.21 billion20. Pierre FabreFrance$1.0 billion21. YSL BeautThe Netherlands$889 million22. PolaJapan$878 million23. PZ CussonsUnited Kingdom$828 million24. The Bolton GroupThe Netherlands$739 million25. SunstarJapan$637 million26. The Colomer GroupSpain$598 million27. MandomJapan$556 mill

9、ion28. LornameadUnited Kingdom$537 million29. MenardJapan$521 million30. FanclJapan$430 million1. UnileverMajor Products: Personal careAxe/Lynx, Rexona/Sure and Degree deodorants; Dove, Caress, Lux and Lifebuoy soaps; Ponds and Vaseline skin care products; Organics, Salon Selectives, SunSilk, Suave

10、and ThermaSilk hair care products; Close-up and Signal oral care products. HouseholdAla, All, Omo/Persil and Surf laundry detergents; Comfort and Snuggle fabric softeners; Sunlight dish detergent, Domestos bleach, Cif cleaners.New Products: Vaseline Cocoa Butter range, Clear anti-dandruff shampoo, D

11、omestos Zero Limescale bleach. 2. LOralMajor Products:LOral Paris, Garnier, Maybelline New York, SoftSheen Carson.LOral Professionnel, Krastase, Redken, Matrix, Mizani, Pureology LuxuryLancme, Biotherm, Helena Rubinstein, Kiehls, Shu Uemura, Giorgio Armani, Parfums Cacharel, Ralph Lauren Fragrances,

12、 Paloma Picasso, Parfums Guy Laroche, Diesel, Victor & Rolf, Yue-Sai. Active CosmeticsVichy, La Roche-Posay, Skinceuticals, Sanoflore. LOrals operations also include The Body Shop and Galderma, and 50% stakes in Le Club des Crateurs de Beaut and Laboratoires Innov.New Products:LOral Professionnel Co

13、lor Supreme, LOral Professionnel Homme Cover 5 grey hair cover, LOral Paris Glam Shine, Derma Genesis/Skin Genesis, Lancme Rnergie Morpholift Rare line, LOral Professionnel Age Densiforce, La Roche-Posay Substiane anti-aging replenishing care, Maybelline Define-A-Lash, Lancme Virtuose mascara, Shu U

14、emura Art of Hair, Mizani Butter Blend. 3. HenkelMajor Products:Laundry and home care sold under brands such as Persil, Purex, Dixan, Vernal, Mir Colueurs, Pril, Bref, Spee Weier, Riese and Somat. Cosmetics and toiletry brands include Schwarzkopf, Fa, Right Guard, Dial, Igora, Palette, Gliss, Kur, S

15、chauma, Taft, Theramed and Diadermine.New Products: Laundry Purex Natural Elements, Persil 20C formulation;Hair care Palette Golden Gloss Browns, Gliss Kur Oil Nutritive, Schuama Kiwi Glanz, Taft Volume Power, Drei Wetter Taft Sensitive, BlondMePersonal care Fa Naturals shower gel and deodorant, Dia

16、l Yogurt; Skin careDiadermine AgeExcelliumOral careTheramed 2-in-1 freshness, Theramed Titan Fresh. 4. Kaowww.kao.co.jpMajor Products:Household products, personal care products and color cosmetics.New Products: Sofina beaut, Sofina Primavista base makeup, Asience hair care (relaunched globally), Meg

17、urism steam eye mask, Attack Biogel liquid laundry detergent, Mens Biore line (relaunched in Japan).5. Reckitt BenckiserMajor Products: Surface care Cillit Bang, Lysol, Dettol, Harpic. Fabric care Calgon, Vanish, Resolve, Spray n Wash, Woolite.Dishwashing Finish, ElectrasolHome care Airwik, MorteinH

18、ealth and Personal care Veet, Dettols, Clearasil.New Products: Cillit Bang Grease & Floor, Dettol Herbal soap and shower gel, Veet Pump Pack, Mortein with Dettol, Mortein Naturgard range, Airwick Freshmatic Mini. 6. BeiersdorfMajor Products: Skin care, beauty care and toiletries sold under brand nam

19、es that include Nivea, Eucerin, La Prairie, Slek, Labello, 8x4, Florena.New Products: Nivea Diamond Gloss hair products; Nivea My Silhouette body shaping gel; Nivea for Men Extreme Comfort; Nivea For Men whitening oil control (India); Nivea for Men DNAge anti-wrinkle moisturizer; Nivea Good-Bye Cell

20、ulite dietary supplement capsules (U.S. only); Eucerin Hyaluron-Filler eye care. 7. Shiseidowww.shiseido.co.jpMajor Products: Skin care, color cosmetics, sun care, fragrances, hair care and toiletries. Major brands include Shiseido, Carita, Decleor, IPSA, Ettusais, Dicila Parfums Issey Miyake, Parfu

21、ms Jean Paul Gaultier, Parfums Narciso Rodriguez, Nars, Cle de Peau Beaute Za, Parfums Serge Lutens, Urara and Supreme Aupres.New Products: Cl de Peau Beaut La Crmes, Revital, Aqua Label skin care, Acne& skin lightening series, Uno mens skin care, Tsubaki Golden Repair hair care, Urara Makeup, Shise

22、ido BOP intensive skin collective program, Shiseido Zen fragrance (relaunch). 8. LVMHMajor Products: Fragrances and cosmetic sold under brands such as Christian Dior, Guerlain, Givenchy, Kenzo, Acqua di Parma, Parfums Loewe, Benefit, Fresh and Makeup Forever. LVMH also owns Sephora, the beauty produ

23、cts retailer.New Products: Dior Fahrenheit 32 for men, Midnight Poison Addict Shine fragrances, Capture L Ore de Vie, Diorskin foundation, Backstage.Guerlain LInstant Magic, Eau de Shalimar, Aqua Allegoria Figue Iris and Aqua Allegoria Laurier Rglisse, Cruel Gardnia, Cherry Blossom delight, My Insol

24、ence.Parfums Givenchy Organza Jasmin 2007, Very Irresistible Rosa Damascena 2007, Amarige Mimosa 2007, Vetyver, Rouge Interdit lipstick. Parfums Kenzo Tokyo by Kenzo for men, Vintage Edition.Benefit Love Your Look, That Gal face brightening primer.Makeup Forever Aqua Eyes waterproof eyeliners.Acqua

25、de Parma Colonia Intensa.Parfums Loewe Quizas, Quizas Quizas. Fendi Palazzo and Pucci Vivara fragrances. 9. Lionwww.lion.co.jpMajor Products: Oral care (toothpastes, toothbrushes mouthwashes, breath fresheners, dental needs); beauty care (shampoos, conditioners, treatments, hair styling products, me

26、ns hair care, soap, body washes, skin care, antiperspirants and deodorants); fabric care (laundry detergents and additives, bleaches, fabric softeners); home care (dishwashing detergents, disinfectants, household cleaners, kitchen-related products) and insecticides.New Products: Household Soflan wit

27、h Fragrance and Deodorant fabric softener, Top Kaori Tsuzuku chamomile-scented liquid laundry detergent with fabric softener, Look O2 Cleaner (joint product with Henkel), Charmy gel-based dishwasher cleaner/detergent.Oral care Dentor Systema EX Extra Herb, Medish oral care gum.Personal care Ban Deod

28、orant Mist, Ban Refresh Powder Sheets, Bathology skin care, Pro Tec Head mens hair care. 10. ChanelMajor Products: Skin care, color cosmetics and fine fragrances.New Products: Skin care Sublimage Essential Regenerating Cream, Hydramax + Active moisture tinted lotion SPF 15Color cosmetics Facettes do

29、r nail color; Robertson Boulevard limited edition nail collectionFragrance Allure pour Homme Edition Blanche, Chance Eau Frache, Allure Homme Sport Cologne Sport, No. 5 Eau Premire. 11. Yves RocherMajor Products: Skin care, cosmetics and fine fragrances marketed under the brand names of Yves Rocher,

30、 Daniel Jouvance, Dr. Pierre Ricaud and Kiotis. New Products: Fragrance Naturelle, Comme une vidence Homme. Personal care Plaisirs Nature Kiwi eau de toilette and shower gelSkin care Culture Bio. 12. NaturaMajor Products: Natura Ekos, Natura Tododia, Natura Chronos, Natura Mame e Beb, Natura Diversa

31、, Natura Amor Amrica. New Products: Natura Amor Amrica, Natura Natur, Natura Tododia, Natura Diversa Hidratao Prolongada, Natura Chronos Politensor de Soja, Natura Aguas, Natura Fixplant, Natura Faces, Natura Mame e Bebe, Natura Ekos Cacau, Natura Homem Chromo, Natura Erva Doce Hidratante Facial, Na

32、tura Crer Para Ver Bolsa Amiga do Meio Ambiente. 13. GlaxoSmithKlineMajor Products: Toothpaste and mouthwash Aquafresh, Dr. Best, Macleans, Odol, Odol Med 2, Polident, Polygrip, SensodyneDenture care Polident, Polygrip, Corega.New Products: Aquafresh iso-active foaming gel 14. AmorePacificwww.amorep

33、acific.co.krMajor Products: Skin care and makeup Laneige, Iope, Mamonde, Innisfree, Hera, Lirikos.Fragrances Lolita, Lempika, Castel Bajac, Espoir.New Products: Sulwhasoo su Essence, ioPE Whitegen RXC, V=B Yeginseng, premium makeup from Laneige, Happy Bath Blue Spa Essential Body Cleanser. 15. Kosww

34、w.kose.co.jpMajor Products: Skin care, cosmetics and toiletries.New Products: Junkisui skin care. 16. ClarinsMajor Products: Skin care, fine fragrance, color cosmetics and sun care sold under brand names such as Clarins, Thierry Mugler, Azzaro, Stella Cadente and My Blend.New Products:My Blend custo

35、mizable skin care 17. OriflameMajor Products: Skin care, fragrances, color cosmetics, toiletries and accessories.New Products: Enigma and Radiant Lights fragrances, Optimals Radiance Glow self tanner, Lift Expert, Perfect Body, Lash Extreme, Royal Velvet Intensive Revitalizing Cloth Mask. Also, Diam

36、ond Musk, Silky Kiss lipstick, Diamond Cellular Anti-aging cream and Dermoprofessional Bio-Peeling Kit (all in September). 18. LG Household &HealthcareMajor Products: Household laundry and dishwasher detergent, fabric softener, kitchen cleaners. Personal care toothpaste, shampoo, soap, baby care, sk

37、in care, color cosmetics and toiletries.New Products: su:m 37 fermented cosmetics, Borrowing Earth household products. 19. PuigMajor Products: Fragrances Adolofo Dominguez, Agatha Ruz de la Prada, Ague Brava, Anouk, Antonio Banderas, Barbie, Carmen Sevilla, Don Algodon, Maja, Mango, Massimo Dutti, P

38、ach, Quorom, Roasiro Flores, Sportman, Victori & Lucchino, Zara, Boston Man, 1916, Antonio Miro, Azur de Puig, Brummel, Eau dEte, Equinox, Farala, Springfield, Yacht Man Blue, Zinnia.Personal Care Payot, Dennenes, Heno de Pravia, Lactovit, Vitese, Kinesia, Maja, Agua Lavanda Puig, Maderas, Misslyn,

39、Nelia, VF.New Products: Blue Seduction for Women20. Pierre FabreMajor Products: Skin care and hair care products sold under the Avne, Ducray, Pierre Fabric Dermatologie, Klorane, Galnic and Rne Furterer banners. Comments: Pierre Fabres Dermo-Cosmetics unit earmarks 5% of its sales for research proje

40、cts, which are conducted at its centers in Vigoulet-Auzil and Saint-Jacques Hospital in Toulouse. Research conducted in Toulouse is made possible through an agreement between the Pierre Fabre group, the local university hospital and Toulouse University.21. YSL BeautMajor Brands: Fragrances, cosmetic

41、s and skin care products. Brands include Yves Saint Laurent, Roger & Gallet, Stella McCartney, Alexander McQueen, Boucheron and Ermenegildo Zegna.New ProductsFragrance Yves Saint Laurent Elle, Paris Nuit de Fete, Paris Pont des Amours, Opium Poesie de Chine Eaux dOrient, LHomme Yves Saint Laurent Ea

42、u dt 2008, Elle Yves Saint Laurent summer fragrance 2008, Cinma Scnario dt, Baby Doll Magic; Ermenegildo Zegna Z Zegna Fresh; Stella McCartney Stella Sheer 2008.CosmeticsLipTwins. 22. Polawww.pola.co.jpMajor Products: Skin Care Alvita, Whitissimo, Day + Day Vitax, Botanex, 1/f, Plenna, Polissima, BA

43、, Signs Solution 28 Carats, Signs Solution Wrinkle Shot, Evangile Cosmetics Whitissimo, Silfique, Vivoke, Aniak, Maquifard, Super Suncare, Southern CallBody Care Feel & Heal; Hair CareIdea Style, Simfree Hair ColorMens Care Galantom, GR Shot S.New Products: Whitissimo base makeup. 23. PZ CussonsMajo

44、r Products: Personal care products sold under brands including Imperial Leather, Joy, Cussons Kids, Premier, Carex, Baby, Luksja, Makler, Sweet Seventeen, Venus Hair, Original Source. Household product brands including Morning Fresh, Elephant, E, Radiant, Robb, Duck and Minerva.New Products: Imperia

45、l Leather SkinBliss. 24. The Bolton GroupMajor Products: Laundry care productsOmino Bianco, Merito, NibroBathroom/kitchen care and cleanersWC Net, Fornet, Last, Dubro, SolivaisselleSurface & Floor CareCarolin, SMAC, Overlay, Vetril, WC EendHousehold soap productsCyclon, Dorn. Personal CareNeutro Rob

46、erts, Borotalco, Rog Cavaills, Sanogyl, Somatoline, Roberts Fragrance, Acque Alle Rose Robert, Citrosil, Botot, Wetties, Soapy, SilxBeautyCollistar skin care, makeup, hair care.New Products: CollistarLong Lasting Color Line and Nourishment and Lustre Lines for hair care, Body Energizing Treatment fo

47、r men, Global Anti-Age Protection Tanning Face Cream SPF 30-50+, Supertanning Moisturizing Dry Oil SPF 15, Sun Effect Make-Up line, Topgloss Stick Reflex, Magnifica Patch-Lifting-Dermal Filling Repairing Face and Neck Mask, Perfecta Active Neck and Dcollet Cream, Magic Drops self-tanning concentrate, Brightening Touch highlighting concealer, Eye Contour Lifting Treatment for men, Perfect Adherence Shaving Foam, Moisturizing Soothing Sensitive Skins, Perfect Adherence Shaving Foam, Moisturizing Softeni

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