Propyl-pyrazole-triol-PPT-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPropyl pyrazole triolCat. No.: HY-100689CAS No.: 263717-53-9Synonyms: PPT分式: CHNO分量: 386.44作靶点: Estrogen Receptor/ERR作通路: Others储存式: Powder -20C 3 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 100 mg/mL (258.77 mM)*

2、means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制备储备液1 mM 2.5877 mL 12.9386 mL 25.8772 mL5 mM 0.5175 mL 2.5877 mL 5.1754 mL10 mM 0.2588 mL 1.2939 mL 2.5877 mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存式和期限。体内实验请根据您的实验动物和给药式选择适当的溶解案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的作

3、液，建议您现现配，当天使；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分 指该溶剂在您配制终溶液中的体积占)：1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 10 mg/mL (25.88 mM); Clear solution2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 10 mg/mL (25.88 mM); Clear solution3. 请依序添加每种溶剂： 10% DMSO 90% corn oil1/2 Ma

4、ster of Small Molecules 您边的抑制剂师www.MedChemESolubility: 10 mg/mL (25.88 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Propyl pyrazole triol (PPT)种雌激素受体 (ER) 激动剂。Propyl pyrazole triol (PPT) 对 ER 的相对结合亲和 (ER: 49%)是雌激素受体 (ER: 0.12%) 的 410 倍 1。IC50 & Target Estrogen receptor alpha 1体外研究 The EC50 of Propyl py

5、razole triol for the ER-dependent response is 140 pM in ER-U2OS-Luc cells 1.REFERENCES1. /pubmed/18644836/2. Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem.2000 Dec 28;43(26):4934-47.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-