孕酮作用机制 - Medchemexpress - MCE中国

1、Product Data SheetProgesteroneCat. No.: HY-N0437CAS No.: 57-83-0分式: CHO分量: 314.46作靶点: Progesterone Receptor; Endogenous Metabolite作通路: Others; Metabolic Enzyme/Protease储存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性数据体外实验 DMSO : 50 mg/mL (159.00 mM; Need ultrasonic)H2O : 0.

2、1 mg/mL (insoluble)SolventMass1 mg 5 mg 10 mgConcentration制备储备液1 mM 3.1801 mL 15.9003 mL 31.8005 mL5 mM 0.6360 mL 3.1801 mL 6.3601 mL10 mM 0.3180 mL 1.5900 mL 3.1801 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存式和期限：-80C, 6 months; -20C, 1 month。-80C 储存时，请在 6 个内使，-20C 储存时，请在 1 个内使。体

3、内实验请根据您的实验动物和给药式选择适当的溶解案。以下溶解案都请先按照 In Vitro 式配制澄清的储备液，再依次添加助溶剂：为保证实验结果的可靠性，澄 的储备液可以根据储存条件，适当保存；体内实验的作液，建议您现现配，当天使； 以下溶剂前显的百分 指该溶剂在您配制终溶液中的体积占；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的式助溶1. 请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (6.61 mM); Clear solution此案可获得 2.08 mg/mL (6.6

4、1 mM，饱和度未知) 的澄清溶液。以 1 mL 作液为例，取 100 L 20.8 mg/mL 的澄 DMSO 储备液加到 400 L PEG300 中，混合均匀；向上述体系中加50 L Tween-80，混合均匀；然后继续加 450 L 理盐定容 1 mL。2. 请依序添加每种溶剂： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (6.61 mM); Clear solutionPage 1 of 2 www.MedChemE此案可获得 2.08 mg/mL (6.61 mM，饱和度未知) 的澄清溶液。以 1 mL 作液

5、为例，取 100 L 20.8 mg/mL 的澄 DMSO 储备液加到 900 L 20% 的 SBE-CD 理盐溶液中，混合均匀。3. 请依序添加每种溶剂： 10% DMSO 90% corn oilSolubility: 2.08 mg/mL (6.61 mM); Clear solution此案可获得 2.08 mg/mL (6.61 mM，饱和度未知) 的澄 溶液，此案不适于实验周 期在半个以上的实验。以 1 mL 作液为例，取 100 L 20.8 mg/mL 的澄 DMSO 储备液加到 900 L 油中，混合均匀。BIOLOGICAL ACTIVITY物活性 Progesteron

6、e种类 醇激素，可调节经周 期，对怀孕很重要。IC & Target Human Endogenous Metabolite体内研究 Progesterone (Injections; 1 mg; three consecutive daily) stimulates vessel maturation in the mouse endometrium4.Animal Model: Adult female mice (7-13 wk, 18-28 g)4Dosage: 1 mgAdministration: Injections; three consecutive dailyResult:

7、 Stimulated vessel maturation in the mouse endometrium.户使本产品发表的科研献 Hum Reprod. 2019 May 1;34(5):804-812. Eur J Med Chem. 2019 Mar 22;171:265-281. J Neurosci Methods. 2018 Sep 1;307:240-247. Patent. US20200129476A1 Patent. US20200078369A1See more customer validations on HYPERLINK www.MedChemE www.Med

8、ChemEREFERENCES1. Schindler AE, et al. Classification and pharmacology of progestins. Maturitas. 2003 Dec 10;46 Suppl 1:S7-S16.2. Zava DT, et al. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med. 1998 Mar;217(3):369-78.3. Komesaroff PA, et al. Effects of wild yam

9、 extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric. 2001Jun;4(2):144-50.4. Girling JE, et al. Progesterone, but not estrogen, stimulates vessel maturation in the mouse endometrium. Endocrinology. 2007 Nov;148(11):5433-41.Epub 2007 Aug 9.McePdfHeightPage 2 of 3 www.MedChemECaution: Product has not been fully validated for medical applications. Fo