【北京大学-病理学试题知识点】_4肿瘤

1、For09g础bycs病理第四章肿瘤自测网题共74题注：3、4、5、6题有图见附1. Workersinthedyeindustryaremostpronetowhichofthefollowingtumors?/aA.Aarcinomaofthelung8. SquamouscellcarcinomaoftheskinCCC.BasalcellcarcinomaoftheskinDDD.CarcinomaofthestomachE.Carcinomaoftheurinarybladder2. Whichofthefollowingtumorshasbeenassociatedmoststro

2、nglywithapossibleviraletiology?AAA.Carcinomaofthelung/广B.Burkitt'slymphomaC.Carcinomaoftheesophagus/DD.Follicularlymphoma/广E.Fibrosarcoma3. A72yearoldfemalehasbeenfeelingfatiguedforweeks.Shehashada10kgweightlossinthepastcoupleofmonths.Shehassomenausea,butnovomiting,hemoptysis,orhematemesis.Shedo

3、esnothaveacough.Sheisafebrile.Themostlikelyexplanationforthesefindings,fromthegrossappearanceoftheliverseenhere,isthepresenceof:A. HepaticadenomasB. Metastaticadenocarcinoma/CC.HepatocellularcarcinomaD.ThistumorshouldexpressAFPoncofetalprotein/E.Micronodularcirrhosis4. Whichoneofthefollowingstatemen

4、tsismostappropriateforthelesionshownhere?A. Thistumorisalwayswell-differentiatedB. ThegrowthpatternforthetumorislocalinvasionC. MetastasismaybeexistwhenthetumorisidentifiedD.TheetiologyofthetumorisrelatedtospecificvirusE.Noneofabove5. A40-year-oldfemalehasnotedsomeintermenstrualbloodingandfeltpelvic

5、discomfort.Apelvicexaminationisperformedandthecervicallesionseenhereisfoundandahysterectomyperformed.Whichoneofthefollowingstatementsismostappropriatebasedontheappearanceofthislesion?AA.ThislesionistheresultofsmokingFor09g础bycst'B.ThisisabenignlesionthatwillnotrecurCThisisamalignantlesionthatwil

6、lbevlethalD.ThiskindoftumorisnotrelatedtoHPV,E.Syphilisisthemaincauseofthelesion6. A68-year-oldmaleisfoundtohaveoccultbloodinthestoolonphysicialexamination.Acolonoscopyisperformed,andthelesionseenherewasfoundandresected.Whichofthefollowingstatementsismostappropriateforthispatient?AA.Hischildrenhavea

7、highriskforasimilarlesionB.ThisisabenignlesionthatwillnotrecurC.ThislesionistheresultofsmokingD.Asexuallytransmitteddiseaseledtothislesion十E.Metastasesfromthislesionmaybepresent7. Whichofthefollowingisthemostcommongrowthpatternfortransitionalcellcarcinoma?A.Ulcerative/BB.OdularC.Leatherlike-rD.Cysti

8、cE.Papillary8. Basalcellcarcinomaismostcommoninwhichlocationintheelderly?A.HandsB.FaceC.FeetD.LiverE.Trunk9. ThemostcommoncauseofdeathfromcancerinChinaisA. StomachcancerB. LivercancerC. LungcancerDD.BreastcancerE.Coloncancer10. Whichoneofthefollowingitemsismosthelpfulindistinguishingpoorlydifferenti

9、atedcarcinomafromsarcoma?A.Thegrowthpattern/B.ThemannerofspreadC.TheageofpatientFor09g础bycsDD.ThelocationofthetumorEEE.Reticulumfiberstain11. Seedingmetastasisismostcommoninwhichofthefollowingmalignancies?A.Melanoma/1B.Gastricsignet-ringcarcinoma/广C.BreastcarcinomaDD.OsteosarcomaEE.Squamouscarcinoma

10、ofpenis12. Whichonethefollowingofstatementsconcerningthetotalcellcycletimeintumorsismostappropriatewhenitiscomparedwithnormalcells?A.3timesfasterthanthatofnormalcellsB.2timesfasterthanthatofnormalcellsC.EqualorevenlongerthanthatofnormalcellsD.5timesfasterthanthatofnormalcellsE.Muchslowerthanthatofno

11、rmalcells13. AnalysisofcancerswhichhavemetastasizedrevealsamutationwhichresultsindecreasedcellsurfaceexpressionofE-cadherin.Whichofthefollowinggenesismostlikelymutatedtoproducethesefindings?A.Beta-catenin/BB.CyclinDC.BRCA-2/DD.NF-1E.Rb14. Patientswithlong-standingEpstein-Barrvirusinfectionhaveanincr

12、easedriskfordevelopmentofmalignantneoplasmsinadulthood.Whichofthefollowingneoplasmsismostlikelytobefoundinthesepatients?A. KaposisarcomaB. LipomaC.CervicalcarcinomaD.Nasopharyngealcarcinoma/厂E.Endometrialcarcinoma15. Apreviouslyhealthy67-year-oldmanhasbeenfeelingtiredfor5months.Acompletephysicalexam

13、inationisperformedandstoolguaiacispositive.Acolonoscopyisperformed,andalarge,sessile4.0cmmasswithsurfaceulcerationisfoundinthececum.Abiopsyofthismassmicroscopicallyshowsirregularglandswithcrowded,tallcolumnarcellshavingmarkednuclearhyperchromatism.Whichofthefollowingstatementsabouthisconditionismost

14、accurate?AA.Hehashereditarynon-polyposiscoloncancerFor09g础bycs/(B.Ap53mutationispresentintheneoplasticcellsC1C.ThereislackofapoptosisfromafaultyBcl-2geneD'D.HisrelativeshavehereditaryadenomatouspolyposisEE.HehasinheritedafaultyRbgenefromoneparent16. Cellsofurothelialcarcinomademonstrateasinglemu

15、tationcausingcellularinabilitytohydrolyzeGTP,thusresultingincellulartransformation.Whichofthefollowingoncogenesismostlikelyimplicatedinthiscase?，A.c-abl/BB.c-sis/CC.k-ras/DD.c-neuE.c-myc17. Itisknownthatsomepre-existingconditionsarefoundtoprecededevelopmentofmalignantneoplasms.Whichofthefollowingcon

16、ditionsismostlikelytobestatisticallyunrelatedtosubsequentmalignancy?A. CervicalsquamousdysplasiaB. ChronicalcoholismwithhepaticcirrhosisC.EndometrialatypicalhyperplasiaD.UterineleiomyomaE.Chroniculcerativecolitis18. AnunequivocalfeaturesofmalignancyisA.Cellularpleomorphism弋B.Lymphocyticinfiltrationa

17、ttheedgeofthetumorC.NumerousmitoticfiguresD.MetastasesE.Necrosis19. A62-year-oldmanwithan80packyearhistoryofsmokingexperiencesanepisodeofhemoptysis.Onphysicalexaminationhisfaceshowspuffiness,thereissomepedaledemaandbruisesontheskin,andhisbloodpressureis165/100mmHg.Achestradiographrevealsa5cmrightupp

18、erlobelungmass.Afineneedleaspirationofthismassshowssmallcellcarcinoma.Abonescanshowsnometastases.Immunohistochemicalstainingofthetumorcellsislikelytobepositiveforwhichofthefollowinghormones?A.Parathormonerelatedpeptide/B.ErythropoietinC.ACTH/D.InsulinFor09g础bycsEE.Gastrin20. A25-year-oldwomaninexcel

19、lenthealthfounda2cmfirm,roundedmassbeneaththeskinofherupperback.Theoverlyingskinappearsnormal.Themassispalpableandsoft.Shehasnosymptomovermanyyears.Whichofthefollowingneoplasmsisshemostlikelytohave?A1A.Metastaticcarcinoma/广B.Melanoma/'C.LeiomyomaDDD.Lipoma5E.Fibrosarcoma21. A14-year-oldboyhashad

20、lumpsintherightneckforthepast5months.Onphysicalexaminationthereispainlesslymphadenopathyintherightcervicalregion.Oneofthelymphnodesisbiopsiedandonmicroscopicexaminationshowsmanylymphocytesthatarelarge,withclumpedchromatinandoccasionalmitoses.Thecharacterizationofthispopulationoflymphocytesasaneoplas

21、misbestaccomplishedbywhichofthefollowingmethods?A. Immunohistochemicalstainingidentifyingleukocytecommonantigent广B. Generearrangementstudiesthatdemonstrateclonality'C.AdifferentialwhitebloodcountshowingalymphocytosisD.FlowcytometryindicatingahighS-phaseE.Demonstratingnecrosiswithinthemassbylightmicroscopy22. A58-year-oldmandiesafterayear-longillness.Ataut