围绝经期综合征论文：围绝经期综合征益坤饮血清5-HT

1、围绝经期综合征论文：围绝经期综合征益坤饮血清5-HT【中文摘要】通过对治疗前后围绝经期综合征患者的临床情志症状、血清性激素、5-HT的观察，总结益坤饮治疗肾阴虚型围绝经期综合征的临床情志症状疗效及对患者血清5-HT水平的影响，并探讨血清5-HT与本病情志症状的相关性及益坤饮治疗本病的作用机制。研究方法：选择肾阴虚型围绝经期综合征患者86例,根据就诊顺序分为治疗组，对照组，治疗12周，以国内改良的Kupperman量表评分、中医主要情志症状改善情况、血清性激素（E2、FSH及血清5-HT作为观察指标,进行治疗前后的自身及组间对照。研究结果：临床疗效：治疗组患者愈显率达92.59%,对照组患者愈显

2、率达81.25%,两组临床疗效相比差异不显著（P0.05）。治疗后国内改良的Kupperman量表临床症状积分：两组较疗前相比均明显下降，但两组组间比较无显著性差异（P0.05）。中医情志症状疗后治疗组愈显率均在90.0%以上,烦躁易怒、失眠、抑郁及疑心总有效率分别为90.74%92.00%90.38%,明显高于对照组，有显著性差异（p0.05）;血清FSH水平两组均下降，其中治疗组疗效尤明显，两组间比较有显著性差异（P0.05）;围绝经期妇女血清5-HT水平明显升高，与育龄期相比具有显著性差异（PV0.05）,经治疗后，围绝经期妇女血清5-HT水平降低明显，且基本接近于育龄期妇女水平。治疗前

3、血清5-HT水平与E2、FSH线性关系不密切；与烦躁易怒、失眠的程度呈相关性，随烦躁易怒程度的加重，血清5-HT水平呈上升趋势；随着失眠程度的加重，血清5-HT水平呈下降趋势，与抑郁及疑心关系不密切。所以益坤饮是改善围绝经期综合征患者情志症状、纠正神经递质紊乱，调整植物神经功能的有效方剂。结论：益坤饮治疗肾阴虚型围绝经期综合征患者疗效显著，可显著改善烦躁易怒、失眠、抑郁及疑心等情志症状；可降低围绝经期患者血清5-HT,改善临床症状，可升高E2、降低FSH水平,其远期疗效明显优于对照组。由此我们认为“益坤饮”对本病的治疗作用可能是通过改善卵巢的功能，增加体内雌激素的分泌，纠正患者体内单胺类神经递

4、质的紊乱,调整植物神经功能，而达到治疗效果的。【英文摘要】：Beforeandaftertreatmentbypatientswithperimenopausalsyndromeclinicalemotionalsymptoms,serumhormone,5-HTobservation,summarytreatmentofkidneyYinYiKunperimenopausalsyndromeandtheeffectofemotionalsymptomsinpatients5-HTlevels,andtoexploretheserum5-HTandtheassociatedsymptomsof

5、thediseaseandChiKwanYinYitreatmentofthediseasemechanism.ResearchMethods:Select-kidney86patientswithPerimenopausalsyndrome,randomlydividedintotreatmentgroup,thecontrolgroup,treatmentfor12weeks,inordertoimprovetheKuppermanratingscale,medicinegentledispositionsymptomsimprovedconditions,serumsexhormone(

6、E2,FSH)andserum5-HTasobservedindicatorsofself-controlbeforeandaftertreatmentandcontrolgroups.Results:Clinicaleffect:thetreatmentgroupweremarkedlyeffectiverateof92.59%inthecontrolgroupweremarkedlyeffectiverateof81.25%,comparedtwogroupsofclinicalefficacywasnotsignificant(P0.05).Aftertreatment,themodif

7、iedKuppermanscalenationalclinicalsymptomscores:twomorethanthatbeforetreatmentweresignificantlydecreased,butbetweenthetwogroupsshowednosignificantdifferenee(P0.05).TCMtreatmentofemotionalsymptomsmarkedlyeffectiverateintreatmentgroup90.0%,irritability,insomnia,depression,andsuspectthetotaleffectiverat

8、ewas90.74%and92.00%,90.38%,significantlyhigherthanthat,therearesignificantdifferences(p0.05);serumFSHlevelsdecreasedinbothgroups,inwhichMing-treatmentgroupwasbetweenthetwogroupsTherewasasignificantdifferenee(P0.05);perimenopausalwomenserum5-HTlevelsweresignificantlyincreased,andreproductivesignificantdiffereneecomparedto(P0.05),aftertreatment,perimenopausalwomenserum5-HTlevelsweresignificantlylower,andthebasiclevelofclosetowomenofchildbearingage.5-HTpre-treatmentlevelsofserumE2,FSHlinearrelationshipisnotclose;andirritability,insomniawasthedegreeofcorrelat