组胺和抗组胺药课件

1、南开大学(nn ki d xu) 医学院张京玲 王侃 代红胜第一页，共三十一页。第二页，共三十一页。第三页，共三十一页。第四页，共三十一页。Histamine and Antihistamine AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonists第五页，共三十一页。 Together with endogenous peptides, prostaglandins and leukotrienes, and cytokines, they are

2、sometimes called autacoids or local hormones第六页，共三十一页。第七页，共三十一页。stimulate sensory nerve endings Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate.第八页，共三十一页。第九页，共三十一页。stimulate sensory nerve endings Cause a decrease in systolic and diastolic blood pressure and a i

3、ncrease in heart rate.第十页，共三十一页。 Intradermal injection of histamine causes a characteristic wheal-and-flare response, which involves an erythema, an edematous wheal and a red irregular flare surrounding the wheal.第十一页，共三十一页。 To be used in testing gastric acid secretion and diagnosis of leprosy.Decre

4、ase of gastric acid can be seen in malignant anemia and true achlorhydia第十二页，共三十一页。Histamine and Antihistamine AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonists第十三页，共三十一页。第十四页，共三十一页。Histamine and Antihistamine AgentsHistamine and its agonistsHistamin

5、e antagonistsH1 receptor antagonistsH2 receptor antagonists第十五页，共三十一页。First-generation blockersSecond-generation blockers 第十六页，共三十一页。urapidly absorbed orallyu widely distributed and the first-generation drugs enter the CNS readily.uMost metabolized in the liver uMost excreted from the kidney第十七页，共三十

6、一页。stimulate sensory nerve endings Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate.第十八页，共三十一页。第十九页，共三十一页。第二十页，共三十一页。 Sedation, antimuscarinic action, drug allergy, cardiac arrhythmias (astemizole) and possible teratogenic effects.第二十一页，共三十一页。Histamine and Antih

7、istamine AgentsHistamine and its agonistsHistamine antagonistsH1 receptor antagonistsH2 receptor antagonists第二十二页，共三十一页。第二十三页，共三十一页。stimulate sensory nerve endings Cause a decrease in systolic and diastolic blood pressure and a increase in heart rate.第二十四页，共三十一页。第二十五页，共三十一页。第二十六页，共三十一页。第二十七页，共三十一页。第二十八页，共三十一页。Gastrointestinal reaction,CNS reaction, Endocrine system reactionCytochrome P-450 inhibition第二十九页，共三十一页。第三十页，共三十一页。组胺和抗组胺药内容(nirng)总结组胺(z n)和抗组胺(z n)药Histamine and Antihistamine Agents。苯海拉明、异丙嗪（非那根）、氯苯那敏（扑尔敏）、布克利嗪（安其敏）。2-(m-F