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1、药品标准质量标准标准品国际标准品参比标准对照品规格药品质量控制分析质量控制性状无臭异臭熔点熔距毛细管熔点测定热台熔点测定沸程凝点不溶性微粒颗粒细度膨胀度分子大小微晶结晶细度结晶性一般鉴别试验鉴别旋光计阿贝折射计浸入折射计限度检查有色杂质有关物质吸光度吸光系数吸光度比值澄清度氯化物硫酸盐重金属砷盐碘化物铁盐氰化物钡盐钙盐易碳化物易氧化物醚溶性酸性物酸中和容量热原异常毒性衰变放射性核纯度放射性浓度索氏脂肪抽提器丹氏浓缩器不皂化物羟值烷氧基测定范氏氨基氮测定法砷斑炽灼残渣蒸发残渣不挥发物总固体过氧化值干燥失重相溶解度分析装量差异最低装量含量测定含量均匀度溶出度崩解时限药物释放相对密度表观黏度比特性黏

2、度运动黏度旋转黏度计落球黏度计稳定性试验总氮量比重瓶法韦氏比重秤法结冻试验抽针试验悬浮时间共沸法甲苯蒸馏法挥发油测定器滴定液标准比色液耐用性计算机辅助药物分析模式收敛特征特征选择试验集训练集校正集预示集岭回归响应面信号处理图象分析库检索变量校正多变量校正反向传播最优化方法窗口图解技术色谱响应函数色谱优化函数混合物设计统计技术叠加分辨率图示法数值分类法系统矩阵组合法双波长一元线性回归法多波长直线回归法系数倍率法最小二乘法自适应最小二乘偏最小二乘法非线性迭代偏最小二乘P矩阵法正交函数法卡尔曼滤波法适应卡尔曼滤波法卡尔曼增益线性学习机主成分分析主成分回归法逐步判别分析目标因子分析对应因子分析迭代目标

3、转换因子分析法遗忘因子法特征向量投影非线性映射人工神经网络节点线性规划法共轭梯度法专家系统人工智能系统模型测量模型模型化与参数估计决策规则n维空间超平面相似性K最近邻域法快速傅里叶变换交互证实误差修正反馈法负反馈过程分析输出层输入层隐含层碘仿反应丙烯醛反应缩合反应异腈化苯N一溴丁二酰亚胺滴定法永停滴定法两相滴定剩余碱水解法催化热滴定非水催化热滴定提取重量法提取容量法四苯硼钠雷氏铵雷氏盐利伯曼试验马奎斯试验溴化氰试剂本内迪克特试剂茚三酮试剂酸性碘铂酸盐溶液曼德林试剂松柏醇试剂对氨基苯磺酸氨基磺酸氨基磺酸铵氨基蒽醌类染料苏丹蓝CN苏丹绿4B茜素青绿茜素亮紫3B茜素亮紫R氯胺T滴定法N- 溴代苯二甲

4、酰亚胺滴定法席夫碱氧瓶燃烧法溴酸盐滴定法不可逆指示剂卡可基邻二氮菲本生阀二苯甲酮杜瓦瓶费林反应折光测定法铜刨花拓奎反应对萘酚苯甲醇溶剂蓝19收敛酸锌收敛酸镉坚牢绿FCF搔洛铬绿 V150热色效应呫吨硫色素反应拉尼镍2,6二氯靛酚滴定法坂口试验麦芽酚反应莫利希试验缩合物埃光子能量外转换电子构型电子跃迁拉波特规律末端吸收肩峰曲折拐点桑德尔灵敏度深色效应浅色效应蓝移红移解线性方程组法等吸光点法二波长分光光度法三波长分光光度法导数分光光度法pH指示剂吸光度比值测定法多组分光谱分析电荷转移光谱荧光分析法分子荧光分析法流动吸收池微量吸收池长光程吸收池热谱带迈克尔森干涉仪荧胺丹酰氯猝灭荧光测定法化学发光免疫

5、分析法荧光免疫分析酶免疫分析鲁米诺荧光偏振免疫分析胶束增敏荧光分析法伸缩振动弯曲振动变形振动对称伸缩振动不对称伸缩振动剪式振动平面摇摆振动非平面摇摆振动扭曲振动呼吸振动振动弛豫振动偶合基频吸收带倍频吸收带费米共振能斯特灯镍铬线圈硅碳棒双光束光学零位平衡系统电比率记录式电学零位平衡系统漫反射衰减全反射多次内反射光束聚焦装置聚苯乙烯薄膜波数压片法石蜡糊法膜法光管热电偶检测器戈雷检测器氘化三甘氨硫酸酯检测器碲化汞一碲化镉复合半导体检测器指纹区光谱检索谱线检索光谱差减法红外光吸收参比图谱光度滴定法酸性染料比色法氨基硫脲比色法钯离子比色法四氮唑比色法科伯试剂检测限系统适用性峰不对称度峰重叠分层胶束色谱法

6、填料极性正相反相疏溶剂作用亲硅羟基作用硅胶氧化铝化学键合相十八烷基硅烷键合硅胶氨基硅烷键合硅胶离子交换纤维素微晶纤维素聚苯乙烯凝胶琼脂糖凝胶聚丙烯酰胺凝胶葡聚糖凝胶己烷磺酸钠十二烷基硫酸钠微量注射器柱超载积分仪色谱数据处理机色谱工作站高效薄层色谱法过压薄层色谱法带状色谱连续展开短床连续展开斑点再浓集原位定量法床外因素背材预制板硅胶H硅胶G荧光剂薄层板贮箱点样器微升毛细管模板热微量转移法试剂喷雾器紫外线灯线性扫描锯齿扫描干装柱法湿装柱法固定相涂布内标物科瓦茨保留指数官能团保留指数亚甲基单位有效碳数相特征常数罗尔施奈德相常数麦克雷诺兹相常数布朗三角图形法气体净化器戈雷柱熔融二氧化硅空心柱分流无分流

7、尾吹气进样隔膜胶垫闪蒸进样法柱上进样器鸭嘴阀针导顶空浓缩进样器冷柱头进样器卡套聚氨酯卡套石墨卡套皂土一34蒙脱土混合固定相高分子多孔小球热能分析器气相色谱-傅里叶变换红外光谱联用仪高分辨气相色谱法联接头流速程序高效液相色谱法再循环色谱法脱气在线脱气设备低压梯度泵往复隔膜泵齿轮泵注射泵单向阀进样阀柱切换质量分析检测器程序波长检测器光电二极管阵列检测器多维检测等高线色谱图三维色谱图二次化学平衡编辑对话衰减时间常数响应时间时间谱带展宽空间谱带展宽保留隘口重叠峰基线分离峰峰谷驼峰试样在线预处理手性固定相手性拆分离子抑制液相色谱-质谱联用仪传送带接口直接液体进样热喷雾接口电喷雾接口液体离子蒸发单分散气雾

8、形成接口柱前衍生化柱后衍生化衍生化反应小管重氮甲烷迁移时间平板电泳毛细管电泳胶束动电毛细管色谱法内电渗电迁移进样抽空进样静力进样柱上检测器示差脉冲极谱法电子电位计参比电极饱和甘汞电极氯化银电极指示电极银电极盐桥电解电流质谱图道尔顿相对强度极限前体全氟煤油离子一分子复合物双价离子麦氏重排拉曼效应棒图扇形磁场质谱仪名义质量准确质量磁阻叠片磁铁十倍程象电流分立二发射极软离子化方法灯丝准分子离子大气压离子化静电喷雾二次离子质谱法溅射现象近距碰撞等离子体解吸质谱法激光解吸质谱法粒子诱导质谱法直接进样杆加热贮槽进样器粒子束重建总离子流各向异性各向异性屏蔽软脉冲五重峰六重峰七重峰偕偶邻偶偏共振去偶选择去偶反

9、门控去偶反磁性屏蔽J调制法谱编辑不灵敏核极化转移增益法无畸变极化转移增益法双量子转移实验drug standardquality standardstandard substanceinternational standard substancereference standardreference substancespecificationdrug quality controlanalytical quality controlcharacteristicsodorlessforeign odormelting pointmelting rangecapillary melting po

10、int determi-nationhot stage melting point determi-nationboiling rangecongealing pointparticulate matterfineness of the particlesswelling degreemolecular sizemicrocrystalcrystal fineness crystallinitygeneral identification testidentificationpolarimeterAbbe refractometerimmersion refractometerlimit te

11、stforeign pigmentrelated substanceabsorbancespecific absorbanceabsorbance ratioclaritychloridesulfateheavy metalarsenic saltiodideiron saltcyanidebarium saltcalcium saltreadily carbonizable substancereadily oxidizable substanceether-soluble acidic matteracid-neutralizing capacitypyrogenundue toxicit

12、ydecayradionuclide purityradioactive concentrationSoxhlet extractorDanish concentratornon-saponifiable matterhydroxyl valuealkyloxy determinationvan Slyke methodarsenic stainresidue on ignitionresidue on evaporationnon-volatile mattertotal solidperoxide valueloss on dryingphase solubility analysisco

13、ntent uniformityminimum fillassayuniformity of dosage unitsdissolutiondisintegrationdrug releaserelative densityapparent viscosityspecific intrinsic viscositykinematic viscosityrotating cylinder viscometerfalling sphere viscometerstability studynitrogen contentpycnometric methodhydrostatic method, W

14、estphalbalance methodfreezing testconsistence testsuspension timeazeotropic methodtoluene distillation methodvolatile oil determination apparatusvolumetric solution, VSstandard color solutionruggednesscomputational pharmaceutical analysis,computer-aided pharmaceutical analysispatternconvergencefeatu

15、refeature selectiontest settraining setcalibration setprediction setridge regressionresponse surfacesignal processingimage analysislibrary searchingvariate calibrationmultivariate calibrationback propagationoptimization methodwindow diagram techniquechromatographic response function, CRFchromtograph

16、ic optimizationfunction, COFmixture design statistic techniqueoverlapping resolution mapsnumerical taxonomysystem matrix combination methoddual-wavelength linear regression methodmulti-wavelength linear regression methodK-ratio method, signal multiplier methodleast square methodadaptive least square

17、partial least square methodnonlinear iterative partial least squareP-matrix methodorthogonal function methodKalman filtering methodadaptive Kalman filtering methodKalman gainlinear learning machineprincipal component analysis, PCAprincipal component regression methodstepwise discriminate analysistar

18、get factor analysiscorrespondence factor analysisiterative target transform factor analysis methodforgetting factor methodeigenvector projectionnonlinear mappingartificial neural networknodelinear programming methodconjugate gradient methodexpert systemartificial intelligencesystem modelmeasurement

19、modelmodeling and parameter estimationdecision rulen-dimensional spacehyperplanesimilarityK-nearest neighbor methodfast Fourier transformcross-validationerror correct feed-back methodnegative feedbackprocess analysisoutput layerinput layerhidden layeriodoform reactionacrolein reactioncondensation re

20、actionphenyl isocyanideN-bromosuccinimide titrationdead-stop titrationdiphasic titrationresidual basic hydrolysis methodcatalytic thermometric titrationnonaqueous catalytic thermometric titrationextraction gravimetryextraction titrationsodium tetraphenylborateammonium reineckateReinecke saltLieberma

21、nn testMarquis testcyanogen bromide reagentBenedict reagentninhydrin reagentacidified iodoplatinate solutionMandelin reagentconiferyl alcohol reagentsulfanilic acidsulfamic acidammonium sulfamateaminoanthraquinone dyesSudan blue CNSudan green 4Balizarin viridinealizarin brilliant violet 3Balizarin b

22、rilliant violet Rchloramine-T titration, CAT titrationN-bromophthalimide titrationSchiffs baseoxygen flask combustionbromate titrationirreversible indicatorcacodylorthophenanthrolineBunsen valvebenzophenoneDewar flaskFehlings reactionrefractometrycopper turningsThalleoquin reactionp-naphtholbenzeins

23、olvent blue 19zinc styphnatecadmium styphnatefast green FCFsolochrome green V150thermochromism effectxanthenethiochrome reactionRaney nickel2, 6-dichlorindophenol titrationSakaguchi testmaltol reactionMolisch testcondensation substanceangstrm, photonexternal conversion of energyelectronic configurat

24、ionelectron transitionLaports lawend absorptionshoulder peakdeflectiondeflection pointSandells sensitivityhyperchromic effecthypsochromic effectblue shiftred shiftsimultaneous equations methodisosbestic point methoddual wavelength spectrophotometrythree wavelength spectrophotome-tryderivative spectr

25、ophotometrypH indicator absorbance ratio methodmulticomponent spectrophotometrycharge-transfer spectrumfluorimetrymolecular fluorescent methodflow cell, flow cuvettemicro celllong path cellhot bandsMichelson interferometerfluorescamine dansyl chloride, DANS-Cl quenching fluorometrychemiluminescence

26、immunoassay, CIAfluorescence immunoassay, FIA enzyme immunoassay, EIA luminol fluorescence polarization immuno-assay, FPIAmicellar enhanced spectrofluoro-metric methodstretching vibrationbending vibrationdeformation vibrationsymmetrical stretching vibrationasymmetrical stretching vibrationscissoring

27、 vibrationrocking vibrationwagging vibrationtwisting vibrationbreathing vibrationvibrational relaxationvibrational couplingbasic frequency absorption bandmultiple frequency absorption bandFermi resonanceNernst glowernichrome coilsglobarsdouble beam optical-null systemratio recording electric-null sy

28、stemdiffuse-reflectanceattenuated total reflectance, ATR multiple internal reflection, MIR beam condenser polystyrene film wave number halide disk method, wafer method, pellet method nujol mull method film method light pipe thermocouple detector Golay detector deuterated triglycine sulfate detector,

29、 DTGS detectormercury cadmium telluride detector, MCT detectorfinger print regionspectral searchspec-finderspectral subtraction methodinfra-red reference spectraphotometric titrationacid-dye colorimetrythiosemicarbazide colorimetrypalladium ion colorimetrytetrazoline colorimetryKober reagentdetectab

30、ilitysystem suitabilitypeak asymmetrypeak overlappingdemixingmicellar chromatographypacking materialpolaritynormal phasereversed phasesolvophobic interactionsilanophilic interactionsilica gelaluminachemically bonded phaseoctadecylsilane chemically bonded silicaamino chemically bonded silicaion-excha

31、nge cellulosemicrocrystalline cellulosepolystyrene gelagarose gelpolyacrylamide gelpolydextran gelsodium hexanesulfonatesodium dodecylsulfate, SDSmicrosyringecolumn overloadintegratorchromatographic data processorchromatographic work stationhigh performance thin-layer chromatography, HPTLCoverpressu

32、re thinlayer chrom-atographystrip chromatographycontinuous developmentshort-bed continuous developmentspot reconcentrationquantitation in situextra-bed factorbacking materialprecoated platesilica gel Hsilica gel Gfluorescent agentplate storage racksample applicatormicrocaptemplatethermo micro-applic

33、ation sepa-ration, TASreagent sprayerultraviolet lamplinear scanningzigzag scanningdry packing methodwet packing methodstationary phase coatinginternal standard substanceKovats retention indexfunctional retention indexmethylene unit, MUeffective carbon numberphase specific constantRohrschneider phas

34、e constantMcReynolds phase constantBrown triangle methodgas purifierGolay columnfused-silica open tubular column,FSOTsplitsplitlessmake-up gasinjecting septumflash evaporating injectionon-column injectorduckbill valveneedle guidehead-space concentrating injectorcold on-column injectorferrulepolyuret

35、hane ferrulegraphite ferrulebentone-34montmorillonite claymixed stationary phaseporous polymer beadsthermo-energy analyser, TEAgas chromatograph/ Fourier trans-form infrared spectrophotometer, GC/FTIRhigh resolution gas chromato-graphy, HRGCunionflow programming high perfor-mance liquid chromatograp

36、hyrecycle chromatographydegassingon-line degasserlow pressure gradient pumpreciprocating diaphragm pumpgear pumpsyringe pumpcheck valveinjection valvecolumn switchingmass analyser detectorprogrammable wavelength detectorphotodiode array detector, DADmultidimensional detectioncontour chromatogramthre

37、e-dimensional chromatogramsecond chemical equilibriumediting dialogattenuationtime constantresponse timeband broading in timeband broading in spaceretention gapfused peaks, overlapped peaksbaseline resolved peakpeak valleyrider peaksample on-line pretreatmentchiral stationary phase, CSPchiral separa

38、tionion suppressliquid chromatograph/massspectrometer, LC/MSmoving belt interfacedirect liquid introduction, DLIthermospray interface, TSPinterfaceelectrospray interface, ESPinterfaceliquid ion evaporation, LIEmonodisperse aerosol generation interface, MAGICpre-column derivatizationpost-column derivatizationderivatizing reaction vialdiazomethanemigration timedisk electrophoresiscapillary electrophoresis, CEmicellar electrokinetic capillarychromatography, MECC,MEKCelectroendosmosiselectromigration injectionvacuum injection

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