附表2具有重要功能线索的人类基因(71个已申请专利的基因清单)

1、附表2：具有重要功能线索的人类基因（71个已申请专利的基因清单）基因名称氨基酸数目染色体表达谱定位结构域筛选活性备注AT22346/19517wide, thyroid, adipocyte, DC55.6% ERacidPPC诱导细胞凋亡AT121839mo cyte, whole blood, myeloid69.6% nuclearCARD诱导细胞凋亡NS30 NS30263/184/17522CD4+ T cell, CD8+T cell, B cell, NK33.3%Golgi, 33.3%plasmic member, 33.3%ERKringle domain (KR)诱导细胞

2、凋亡NS811522liver60.9% nuclear诱导细胞凋亡D54679whole brain, amygadala, myeloid52.2% cytoplasmicSPEC, OLF诱导细胞凋亡NS6411017wide, whole brain, testis39.1 % cytoplasmicDUF786诱导细胞凋亡已开展合作研究NM14032310mo cyte, NK33.3 % ER, 22.2 % vacuolar, 22.2 % plasma membrane诱导细胞凋亡CB111919cervical tumor, lung cancer56.5% cytoplas

3、micPIPKc, PIP5k诱导细胞凋亡，抑制Wnt已开展合作研究NS731558wide39.1 % cytoplasmicRing-finger诱导细胞调亡，激活SRE、CRENM393305826.1% plasma membrane, 26.1 % ER, 17.4 % vacuolar, 17.4 % nuclear诱导细胞凋亡，stat1阳性NM8859214wide, OlfactoryBulb, spinal cord,69.6% nulcearFH2 (Formin homology 2 )激活NF-B、CRE，诱导细胞凋亡NM34447015early erythroid

4、39.1% cytoplasmic激活NF-B、CRE，诱导细胞凋亡NS3072531wide, kidney, renal cell ade carci ma34.8 %: plasma membrane13.0 %: mitochondrial13.0 %: nuclear抑制AP-1，Wnt已开展合作研究NSS301111BM-CD71+ EarlyErythroid, muscle, rhabdomyosarcoma43.5 %: cytoplasmic17.4 %: mitochondrial17.4 %: nuclear抑制AP-1已开展合作研究NSS2117619wide, lu

5、ng, small cell carci ma52.2 %: nuclear26.1 %: cytoplasmic抑制AP-1已开展合作研究NM156391/3812wide, lung, small cell carci ma65.2 %: cytoplasmic26.1 %: nuclearDUF609抑制AP-1已开展合作研究NM40235111PB-CD14+mo cytes,lung, small cell carci ma, cervix, carci ma66.7 %: endoplasmic reticulumSIR2-like抑制AP-1已开展合作研究NM35943812wi

6、de, adipocyte, heart, whole blood95.7 %: nuclearKRAB, COG5048抑制AP-1已开展合作研究NS4212513wide, lung, large cell carci ma47.8 %: mitochondrial30.4 %: cytoplasmic抑制AP-1已开展合作研究NM3214039brain, neuroblastoma44.4 %: endoplasmic reticulum22.2 %: Golgi22.2 %: mitochondrial11.1 %: nuclear抑制AP-1已开展合作研究CB252391brain

7、, adult medulla56.5 %: cytoplasmic13.0 %: nuclear抑制AP-1已开展合作研究NS2912078brain, hippocampus65.2 %: nuclear抑制AP-1CB12327939.1 %: nuclear30.4 %: mitochondrial抑制NF-B，NFAT，AP-1；诱导细胞调亡，结合UBC9已开展合作研究NS12822922wide, breast, mammary adenocarcinoma34.8 %: cytoplasmic21.7 %: nuclear抑制SRETF113184Xtestis47.8 %: n

8、uclear30.4 %: mitochondrialhomeodomain抑制SRE，激活CRENM1733611NK, brain65.2 %: cytoplasmicVps26抑制SRENMM2425215skin, mela tic mela ma47.8 %: cytoplasmic26.1 %: nuclear17.4 %: mitochondrial抑制SRENSS07183Xplacenta, choriocarcinoma52.2 %: cytoplasmic21.7 %: nuclearSpot_14抑制SRENM43930416ovary, pooled from 3 a

9、dults47.8 %: nuclear26.1 %: cytoplasmicDUF298激活SRENM40125819Prostate, liver, thyroid, lymphorna burkitts39.1 %: cytoplasmic17.4 %: mitochondrial17.4 %: nuclearTLC; LAG1激活SRE、CRENYM123288X65.2 %: nuclearOUT激活SRENM39531712whole blood, Cortex, whole brain47.8 %: cytoplasmic26.1 %: nuclearRing激活NF-B，SRE

10、、CRE；stat1阳性NL135311CD4+ T cell, CD8+T cell, B cell, NK21.7 %: cytoplasmic 21.7 %: nuclear 17.4 %: vesicles of secretory systemMyosin_tail细胞增殖相关，抑制WntTF95386wide95.7 %: nuclearLER, KRAB, zf-C2H2细胞增殖相关NS20322317monocytes,whole blood, myeloid，CD4+ T cell, CD8+T cell, B cell, NK69.6 %: nuclear细胞增殖相关NS3

11、182605CD4+ T cell, CD8+T cell, B cell, NK91.3 %: nuclearRPS8A细胞增殖相关NS1902153lymphoblasts, endothelial, EarlyErythroid60.9 %: nuclear 26.1 %: mitochondrial细胞增殖相关TF413711Trachea，Pancreas，lung，prostate73.9 %: nuclearSAM_PNT, ETS活化STAT1，2，3，炎症相关转录因子；细胞增殖相关AT466311monocytes,whole blood, myeloid73.9 %: cy

12、toplasmic 13.0 %: nuclearB41, UNC112反义表达质粒抑制NF-B，NFAT；细胞增殖相关SM1144616eye, brain, mixed66.7 %: extracellular, including cell wall 11.1 %: vacuolar 11.1 %: cytoplasmic 11.1 %: mitochondrialSCP, CLECT影响ELK1活性的多核苷酸及其编码多肽和用途NS26327311brain, testis, eye, uterus60.9 %: cytoplasmic 21.7 %: nuclearMethyltran

13、sf_5影响ELK1活性的多核苷酸及其编码多肽和用途NSS1731857blood, placenta, lung66.7 %: endoplasmic reticulum 22.2 %: plasma membrane 11.1 %: cytoplasmic影响ELK1活性的多核苷酸及其编码多肽和用途NS41887lymphoblasts, lymphoma burkitts, BM-CD34+, endothelial47.8 %: cytoplasmic 26.1 %: nuclear 17.4 %: mitochondrial影响ELK1活性的多核苷酸及其编码多肽和用途NS561598

14、wide56.5 %: nuclear 17.4 %: cytoskeletal 13.0 %: mitochondrial影响ELK1活性的多核苷酸及其编码多肽和用途NS1552972brain55.6 %: endoplasmic reticulum 22.2 %: plasma membrane影响ELK1活性的多核苷酸及其编码多肽和用途NS2012578ovary, adenocarcinoma33.3 %: Golgi 33.3 %: plasma membrane 33.3 %: endoplasmic reticulumTB2_DP1_HVA22影响ELK1活性的多核苷酸及其编码

15、多肽和用途NS25925416eye, retinoblastoma47.8 %: nuclear 17.4 %: cytoplasmic 17.4 %: mitochondrial影响ELK1活性的多核苷酸及其编码多肽和用途NS125200Xhypothalamus, putuitary, uterus56.5 %: nuclear 17.4 %: cytoplasmic 13.0 %: mitochondrialTFA激活CRE，抑制WntD321116heart65.2 %: cytoplasmic 17.4 %: mitochondrial激活CRENM1493935lymphobla

16、sts, earlyerythroid, testis69.6 %: cytoplasmic 21.7 %: nuclearCTLH激活CRECM34976wide52.2 %: cytoplasmic 26.1 %: nuclear 17.4 %: mitochondrialRING, BBOX, BBC, PRY, SPRY激活CRECM120712wide47.8 %: mitochondrial 43.5 %: cytoplasmicSPRY激活CRENS3152306bone marrow, chronic myelogenous leukemia55.6 %: endoplasmi

17、c reticulum 22.2 %: plasma membraneFar-17a_AIG1激活CRENS11507appendix60.9 %: cytoplasmic 21.7 %: nuclearSTAG激活CRESM21895spinalcord, salivarygland, BM-CD34+56.5 %: cytoplasmic 21.7 %: nuclearC1Q激活CRENS246237brain, lung, testis, adult, pooled whole34.8 %: nuclear 21.7 %: mitochondrial 17.4 %: cytoplasmi

18、c 13.0 %: Golgi激活CRED1922713colon, kidney, stomach, adult, whole pooled, eye, retinoblastoma34.8 %: cytoplasmic 21.7 %: extracellular, including cell wall 21.7 %: mitochondrialARF激活NF-B, SRENS28123911PB-CD19+B cell, T cell, NK34.8 %: cytoplasmic 34.8 %: nuclear 13.0 %: mitochondrialANK激活NF-B已开展合作研究XN120414brain43.5 %: mitochondrial 43.5 %: nuclear激活NF-BNS43222519ea