哈医大精品课程营养与食品卫生学营养学基础

1、第一章第一章 营养学基础营养学基础碳水化合物碳水化合物CarbohydratesMain contents Definition of carbohydrates Classification of carbohydrates Digestion & absorption of CHO Functions of carbohydrates Disorders related to CHO metabolism Dietary reference intakes of CHOs|Carbohydrates are one of the three macronutrient types

2、that provide energy to our bodies. Carbohydrates contain carbon, hydrogen, and oxygen. 碳水化合物：属三大能量营养素之一，碳水化合物：属三大能量营养素之一，主要由碳、氢、氧构成。主要由碳、氢、氧构成。 一一、碳水化合物的定义碳水化合物的定义 What are carbohydrates?|Carbohydrate can be abbreviated as “CHO”.|We obtained carbohydrates predominantly from plant foods such as fruit

3、s, vegetables, and grain.Why?Plants make carbohydrates through the process of photosynthesisEnergy from sunCarbon dioxide from airGlucose stored in plantWaterWater+ Carbon dioxideGlucose光合作用光合作用二、碳水化合物的分类二、碳水化合物的分类Classification of carbohydrates双糖双糖多糖多糖HOHCH2OHHOHOHHOHHHGlucoseOHOHHOHHOHCH2OHCH2OHFr

4、uctoseHOOHOHOHHHHHCH2OHGalactoseThe three most common monosaccharides. ALL of them contain identical atomsStructure of monosaccharidesMonosaccharides-Glucose（葡萄糖）|Glucose is the most abundant sugar molecule found in our diets and in our foods.| Glucose does not generally occur by itself in foods but

5、 attaches to other sugars to form disaccharides and complex carbohydrates.| In our bodies, glucose is the preferred source of energy for the brain.食物中最多的单糖，但不以单独形式存在，常食物中最多的单糖，但不以单独形式存在，常与其他糖形成双糖或多糖的形式存在，葡萄糖与其他糖形成双糖或多糖的形式存在，葡萄糖优先为大脑提供能量。优先为大脑提供能量。Monosaccharides-Fructose（果糖）|Fructose is also called

6、fruit sugar.|Fructose is the sweetest natural sugar, occurs naturally in fruits and vegetables. PrefixMonosaccharides-Galactose（半乳糖）|Galactose does not occur alone in foods. It joins with glucose to create lactose, one of the disaccharides.Sweetest monosaccharides?The most abundant monosaccharides ?

7、The sweetest：fructoseThe most abundant：glucose Disaccharide（双糖）（双糖）|Disaccharide: A carbohydrate compound consisting of two sugar molecules joined together.The three most common disaccharides found in foods are lactose（乳糖）（乳糖）, maltose （麦芽糖）（麦芽糖）, and sucrose （蔗糖）（蔗糖）.Disaccharides Lactose（乳糖）（乳糖）Gl

8、ucoseGalactoseLactose| Lactose: Consist of one glucose molecule and one galactose ( (半乳糖）半乳糖） molecule.DisaccharidesMaltose （麦芽糖）（麦芽糖）|Maltose: also called malt sugar, consist of two molecules of glucose.| It does not generally occur by itself in foods, but results as a by-product of digestion.Gluco

9、seDisaccharidesSucrose（蔗（蔗糖）糖）vSucrose is composed of one glucose molecule and one fructose（果糖）（果糖） molecule. vSucrose provides much of the sweet taste found in honey, fruits, and vegetables.How about the Sucrose and fructose?vSweeter than lactose or maltose, why?哪种双糖最甜哪种双糖最甜-麦芽糖，蔗糖，乳糖？麦芽糖，蔗糖，乳糖？麦芽糖

10、麦芽糖-2个葡萄糖个葡萄糖蔗糖蔗糖-1个葡萄糖个葡萄糖+1个果糖个果糖乳糖乳糖-1个葡萄糖个葡萄糖+1个半乳糖个半乳糖蔗糖蔗糖Oligosaccharide（寡糖）（寡糖）v Oligosaccharide are composed of 3 to 10 monosaccharides.v The most common oligosaccharides are raffinose （棉籽糖）（棉籽糖）and stachyose（水苏糖）（水苏糖）. v They can not be degraded by enzymes in the small intestine, but can be

11、 broke down in the large intestine.Polysaccharides（多糖）（多糖）Polysaccharides include starch（淀粉）, glycogen（糖原） and most fibers（纤维）.PolysaccharidesStarchGlycogenFiber淀粉淀粉糖原糖原纤维纤维Polysaccharide-Starch|Starch: A polysaccharide stored in plants and is the storage form of glucose in plants.（淀粉是葡萄糖在植物中的贮存形式）（

12、淀粉是葡萄糖在植物中的贮存形式） | Excellent food sources of starch include?grains (wheat, rice, corn, oats, and barley), legumes (peas, beans, and lentils), and tubers (potatoes and yams).| Our bodies easily digest most starches， we call them digestible starch(可吸收淀粉）可吸收淀粉）.| 根据其结构可分为直链淀粉根据其结构可分为直链淀粉（amylose）和支链淀粉和

13、支链淀粉（amylopectin），），前前者易使食物老化，后者易使食物糊化者易使食物老化，后者易使食物糊化（gelatinization ）。| However, some starch in plants is not digestible and is called resistant starch（抗性淀粉）（抗性淀粉）.|抗性淀粉：指健康者小肠中不吸收的抗性淀粉：指健康者小肠中不吸收的淀粉及其降解产物。淀粉及其降解产物。 | When our intestinal bacteria try to digest resistant starch, a fatty acid called

14、 butyrate is produced.|Consuming resistant starch may be beneficial because butyrate is suggested to reduce the risk of cancer.| 豆科食物豆科食物（Legumes）含有的抗性淀粉含有的抗性淀粉比谷类比谷类、蔬菜和水果多。蔬菜和水果多。Bean sproutGreen soybean| Glycogen: A polysaccharide stored in animals, including humans.| Very little glycogen exists

15、in food.| Thus, glycogen is not a dietary source of carbohydrate.Polysaccharide-Glycogen（糖原）（糖原）Which tissues are abundant in glycogen?We store glycogen in our muscles and liver. We can break down glycogen very quickly into glucose when we need it for energy.| Based on the water soluble ability, fib

16、er can be classified into soluble fibers and insoluble fibers.| Insoluble fibers（不溶性纤维）（不溶性纤维）: cellulose（纤维素）（纤维素）, hemicellulose（半纤维素）（半纤维素） and xylogen（木质素）（木质素）. .| Soluble fibers（可溶性纤维）（可溶性纤维）: :果胶果胶（pectin) ，树胶和粘胶树胶和粘胶. . Polysaccharide-Fiber|膳食纤维膳食纤维（dietary fiber）：是指植物性食物：是指植物性食物或原料中糖苷键大于或原料

17、中糖苷键大于3个，不能被人体个，不能被人体小肠消化和吸收，但对人体健康有意义小肠消化和吸收，但对人体健康有意义的碳水化合物。的碳水化合物。|膳食纤维包括部分非淀粉多糖（纤维素、膳食纤维包括部分非淀粉多糖（纤维素、半纤维素、木质素、果胶等）、半纤维素、木质素、果胶等）、抗性淀抗性淀粉粉、葡聚糖葡聚糖以及以及部分低聚糖部分低聚糖等。等。 (1)(1)增强肠道功能、有利粪便排出增强肠道功能、有利粪便排出 Helps prevent constipation and other intestinal problems by keeping our stools moist and soft.Funct

18、ions of dietary fiberDietary fiber increases faecal bulk through water binding by fiber.Fiber gives gut muscles“something to push” and makes it easier to eliminate stools. (2) 控制体重和减肥控制体重和减肥 May enhance weight loss, as eating a high fiber diet causes a person to feel more full.Fiber absorbs water, e

19、xpands in our intestine, and slows the movement of food through the upper part of the digestive tract. (3)(3) 降低血糖和血胆固醇降低血糖和血胆固醇Decrease the level of blood sugar and cholesterol May reduce the risk of heart disease by delaying or blocking the absorption of dietary cholesterol into the bloodstream. (

20、4)(4) 降低结肠癌的发病风险降低结肠癌的发病风险May reduce the risk of colon cancer.While there is still some controversy surrounding this issue, many researchers believe that fiber binds cancer-causing substances and speeds their elimination from the colon. 三、碳水化合物的消化及吸收三、碳水化合物的消化及吸收|We have learned many forms of CHOs c

21、ontaining in our foods, which one is the form of energy used by our bodies?|The primary goal of CHO digestion is to break down polysaccharides and disaccharides into monosaccharides that can be converted to glucose.Digestion of carbohydrates in foods (In the mouth)CHO digestion begins in the mouth.Q

22、uestion: When you eat steamed bread（馒头）, notice that you can actually taste it becoming sweeter, Why? Saliva amylase（淀粉酶）（淀粉酶） breaks starch( (淀粉）淀粉） into smaller particles and eventually into the maltose（麦芽糖）（麦芽糖）.| Disaccharides are not digested in the mouth. |In the stomach, all digestion of CHOs

23、 ceases.Digestion of carbohydrates in foods (In the stomach)|Because the acid in the stomach inactivates most of the salivary amylase enzyme.Would you guess the reasons?|The majority of carbohydrate digestion occurs in the small intestine.Digestion of carbohydrates in foods (In the small intestine)|

24、Pancreatic amylase secreted by the pancreas into the small intestine.|Pancreatic amylase continues to digest any remaining starch into maltose（麦芽糖）（麦芽糖）.Additional enzymes found in the intestinal tract break down disaccharides into monosaccharides. MaltoseSucroseLactoseGlucoseGlucose & FructoseG

25、lucose & GalactoseMaltaseSucraseLactaseAbsorbed by mucosal cellsBlood stream麦芽糖蔗糖乳糖Transform of carbohydrates in the liverFructose&galactoseGlucoseCellEnergyGlycogenBlood vesselsBlood vessels| Excess glucose can be transformed and stored as glycogen in liver and muscles. Our liver can store

26、70g (or 280 calories) of glycogen. Our muscles can normally store about 120 g (or 480 cal) of glycogen. Transform of carbohydrates in the liver|Liver glycogen：maintains blood glucose levels, provide the needs of our cells, including those of our brain, spinal cord and red blood cell.|In addition, It

27、 provide energy to the muscles during intense exercise（剧烈运动）（剧烈运动）.|We do not possess enzymes that can break down fiber.|Thus, fiber passes through the small intestine undigested and enters the large intestine or colon.There is no any digested process for fiber。|Once into the large intestine, bacter

28、ia break down some undigested carbohydrates, causing the production of gas and a few fatty acids（产酸（产酸、产气）产气）.Digestion of carbohydrates in foods (In the large intestine)|The cells of the large intestine use these fatty acids for energy.|The fiber remaining in the colon adds bulk to our stools and i

29、s excreted in feces.Salivary amylase breaks down starch into shorter polysaccharides and a few maltose.No digestion takes placePancreatic amylase is secreted into small intestine.Majority of starch were digested. Pancreatic amylaseSpecific enzymes； All monosaccharides are absorbed by small intestine

30、 and enter bloodstream.Monosaccharides travel to liver in bloodstream, then to cells to provide energy;Excess glucose is stored as glycogen in liver.Bacteria break down some undigested CHO; remaining fiber is excreted in feces.Summary四四、碳水化合物的功能碳水化合物的功能Function of carbohydrates1. 1.提供和贮存能量提供和贮存能量（pr

31、ovide and store energy）How much？ 4kcal/g.| Some of our cells can also use fat and even protein for energy if necessary. However, our red blood cells can utilize only glucose and our brain & other nervous tissues primarily rely on glucose.CarbohydrateFatAmounts of carbohydrate and fat used during

32、 the different extent of exercise.LightModerate Intense67%45%13%87%55%33%Percent contribution to total energy Fat breakdown is a slow process and require oxygen w e c a n b r e a k down glucose very quickly either with or without oxygen.Function of carbohydrates2.2.节约蛋白质作用节约蛋白质作用 (CHOs spare protein

33、s)定义：定义：当摄入足够的碳水化合物时，可以防止体当摄入足够的碳水化合物时，可以防止体内和膳食中的内和膳食中的蛋白质转变为葡萄糖蛋白质转变为葡萄糖. .糖异生糖异生(gluconeogenesis)Gluconeogenesis: The generation of glucose from the breakdown of protein into amino acids.|When our body uses proteins for energy, the amino acids from these proteins cannot be used to make new cells,

34、 repair tissue damage, support our immune system, or perform any of their other functions.Using amino acids in this manner over a prolonged period of time can cause serious, possibly irreversible, damage to these organs.3.抗生酮作用抗生酮作用（Prevent the generation of ketones)|Ketoacidosis: A condition in whi

35、ch excessive ketones（酮体）（酮体） are present in the blood, causing the blood to become very acidic, which alters basic body functions and damages tissues.Function of carbohydratesLow carbohydrate intake can lead to ketoacidosis( (酮症酸中毒）酮症酸中毒）T h u s , w h e n c a r b o h y d r a t e i n t a k e i s inad

36、equate, our body seeks an alternative source of fuel for the brain and begins to break down stored fat. acetyl-CoA is the metabolites of fatty acid oxidation.If inadequate carbohydrate intake continues for an extended period of time, excess acetyl-CoA can be converted to ketones.The high acidity of

37、the blood interferes with basic body functions, causes the loss of lean body mass, and damages many body tissues.Where do ketones come from?4.4.机体的构成成分5.5.改变食物的色、香、味、型6.6.提供膳食纤维Functions of carbohydrates五五、碳水化合物代谢相关疾病碳水化合物代谢相关疾病 糖尿病 低血糖症 乳糖不耐症|Glucose molecules are too large to cross the cell membra

38、nes of our tissues independently.| To get in, glucose needs assistance from the hormone insulin.血糖的调节过程Glucose in blood enters cellsInsulin stimulates glucose transport into cellInsulin secreted by pancreas enters bloodstreamTissue cell membraneWhen blood glucose is highGlucagon secreted by pancreas

39、 enters bloodstreamGlucagon stimulates glycogen breakdownGlucose is secreted into bloodstream and transported to cellsLiver cell membraneWhen blood glucose is low胰高血糖素|Normally, insulin and glucagon balance each other to maintain blood glucose within a healthy range.| If this balance is altered, it

40、can lead to health conditions such as diabetes（糖尿病）（糖尿病） or hypoglycemia（低血糖症）（低血糖症）.血糖指数（Glycemic index，GI） 定义：50g50g含碳水化合物的食物血糖应答曲线下面积与同一个体摄入50g50g 碳水化合物的标准食物（葡萄糖或面包）血糖应答曲线下面积之比。 血糖指数是食物升高血糖潜力的一个参考指标，反应了食物对血糖的影响程度。 高GIGI食物能使血糖突然升高。血糖指数的应用 指导合理膳食，有效控制血糖 糖尿病人 低血糖症患者、运动员 有助于控制体重 改善胃肠道功能 Lactose intol

41、erance: A disorder in which the body does not produce sufficient lactase enzyme（乳糖酶）（乳糖酶）and therefore cannot digest foods that contain lactose, such as cows milk.乳糖不耐症乳糖不耐症（Lactose intolerance）n主要症状：胃肠不适、胀气、痉挛和腹泻等。 It is estimated that up to 70% of the worlds adult population suffer this disorder.

42、Not everyone experiences lactose intolerance to the same extent (small amounts, not tolerant any)Lactose intoleranceLactose intolerance should not be confused with a milk allergy. People who are allergic to milk experience an immune reaction to the proteins found in cows milk.六、膳食参考摄入量六、膳食参考摄入量Dieta

43、ry reference intakes 中国营养学会推荐我国居民的碳水化合物中国营养学会推荐我国居民的碳水化合物的膳食推荐摄入量占总能量的的膳食推荐摄入量占总能量的55%65%。食物食物GI食物食物GI食物食物GI大米饭大米饭88柚子柚子25熟香蕉熟香蕉52酸奶酸奶83鲜桃鲜桃28猕猴桃猕猴桃52牛奶牛奶27.6梨梨36芒果芒果55鲜豆腐鲜豆腐 31.9苹果苹果36菠萝菠萝66生香蕉生香蕉30柑柑43西瓜西瓜72小结小结 碳水化合物的分类及功能碳水化合物的分类及功能 膳食纤维的定义及功能膳食纤维的定义及功能 乳糖不耐症乳糖不耐症HOHCH2OHHOHOHHOHHHGlucoseOHOHHOH

44、HOHCH2OHCH2OHFructoseHOOHOHOHHHHHCH2OHGalactoseThe three most common monosaccharides. ALL of them contain identical atomsStructure of monosaccharidesPolysaccharides（多糖）（多糖）Polysaccharides include starch（淀粉）, glycogen（糖原） and most fibers（纤维）.| When our intestinal bacteria try to digest resistant starch, a fatty acid called butyrate is produced.|Consuming resistant starch may be bene