病理学图片集学习教案

1、会计学1病理学图片集病理学图片集第一页，编辑于星期日：十八点 三十分。共和国二十一世纪第五个生日即将到来的共和国二十一世纪第五个生日即将到来的时刻，精心制作了这个图片集，其中涉及时刻，精心制作了这个图片集，其中涉及了大量精美的、高质量的图片，并附带了了大量精美的、高质量的图片，并附带了大量而且详尽的文字说明。值六一儿童节大量而且详尽的文字说明。值六一儿童节即将到来之际，把它献给祖国，也献给奋即将到来之际，把它献给祖国，也献给奋战在医疗一线的战友。战在医疗一线的战友。2005.05.212005.05.21第1页/共22页第二页，编辑于星期日：十八点 三十分。 Esophageal Varice

2、s 第一部分第一部分第2页/共22页第三页，编辑于星期日：十八点 三十分。Grossly, esophageal varices appear as tortuous, dilated, blue veins running along the long axis of the esophagus.第3页/共22页第四页，编辑于星期日：十八点 三十分。This is a photograph of the actual slide in your class set. Note the markedly dilated veins in the submucosa and in the mus

3、cularis propria of the esophagus. 第4页/共22页第五页，编辑于星期日：十八点 三十分。These dilated varices often cause pressure atrophy and ulceration of the overlying mucosa, as has happened in this case. The subsequent inflammation of the submucosa causes erosion of the thin wall of the varices with subsequent rupture. T

4、he large varix noted by the arrow communicates directly with the lumen and has probably ruptured in the past. It is now thrombosed.第5页/共22页第六页，编辑于星期日：十八点 三十分。Shows thrombosis of a large submucosal varix. Note the ulceration of the overlying mucosa (arrow) and inflammation of the submucosal stroma.第6

5、页/共22页第七页，编辑于星期日：十八点 三十分。Squamous Cell Carcinoma of the Esophagus 第二部分第二部分第7页/共22页第八页，编辑于星期日：十八点 三十分。Gross: This is an example of an ulcerated squamous cell carcinoma of the esophagus. It differs from a benign peptic ulcer of the esophagus in that it is a much larger lesion and rather than being sha

6、rply punched-out, it has irregular borders. Note the perforation in the center.第8页/共22页第九页，编辑于星期日：十八点 三十分。Is a low power view of the histologic section in your class set. (M = mucosa; Sm = submucosa; Mp = muscularis propria). The intact mucosa is to the left of the arrow; the ulcerated carcinoma (C)

7、 is to the right. 第9页/共22页第十页，编辑于星期日：十八点 三十分。Is taken at the juncture (arrow head) of the normal mucosa (M) and the ulcerated carcinoma (C) and it shows another common feature of esophageal cancer. The gross margins of the cancer are often misleading because the tumor frequently spreads longitudinal

8、ly in submucosal lymphatics (double arrows).第10页/共22页第十一页，编辑于星期日：十八点 三十分。Is a section taken through the full thickness of the esophageal wall. Carcinomas of the esophagus are typically deeply infiltrating lesions and this one has extended through the muscularis propria (arrows). 第11页/共22页第十二页，编辑于星期日

9、：十八点 三十分。Shows nests of malignant squamous cells within the submucosa. This is a moderately differentiated squamous cell carcinoma in that there is keratin production. The malignant cells show a common feature of malignancy, namely altered polarity. The differentiating squamous cells within the subm

10、ucosal nests cannot slough keratin to the luminal surface. Instead the keratin accumulates in the center of the nests as spherical keratin pearls (arrow).第12页/共22页第十三页，编辑于星期日：十八点 三十分。Shows the moderately differentiated squamous cell carcinoma with keratin pearls at higher power. 第13页/共22页第十四页，编辑于星期日

11、：十八点 三十分。Mitotic figures are usually common in malignant tumors and often they are abnormal. This is a tripolar mitosis and if you look carefully you can see 3 mitotic spindles.第14页/共22页第十五页，编辑于星期日：十八点 三十分。Chronic Peptic Ulcer of the Stomach 第三部分第三部分第15页/共22页第十六页，编辑于星期日：十八点 三十分。Gross: Chronic peptic

12、 ulcers are typically small (less than 4 cm in diameter), round, sharply punched-out lesions with perpendicular walls and a clean base. Fibrous contracture of the base of the ulcer may cause puckering of the surrounding mucosal folds such that they radiate away from the ulcer in spoke-like fashion.

13、第16页/共22页第十七页，编辑于星期日：十八点 三十分。Is a low power view of the gastric ulcer in your class set. The ulcer (U) lies between the arrows. The intact, but chronically inflamed, gastric mucosa (M) is on either side. Note that the base of the ulcer extends all the way to the serosa of the stomach. Large arteries

14、 (A) are present at the base of the ulcer. Erosion into one of these large arteries could result in massive hematemesis. 第17页/共22页第十八页，编辑于星期日：十八点 三十分。Is a low power view of the full thickness of the gastric wall in the region of the ulcer. This ulcer shows ongoing necrosis and inflammation as well a

15、s fibrous repair and the classic zones of Askenazy are readily apparent. A represents the superficial layer of necrotic debris and acute inflammation. Just below this superficial layer is a zone of active granulation tissue (B) which in the deeper layers matures into a fibrous scar (C). The entire u

16、lcer extends to the serosa of the stomach and the subserosal fat layer is noted by the letter D. Again, notice the large artery at the base of the ulcer. 第18页/共22页第十九页，编辑于星期日：十八点 三十分。The classic zones of Askenazy can be seen to better advantage at higher power. A represents the superficial zone of necrosis and active inflammation, B the zone of active granulation tissue, and C the deep fibrous scar.第19页/