版权说明:本文档由用户提供并上传,收益归属内容提供方,若内容存在侵权,请进行举报或认领
文档简介
1、68%18%14%020406080PCICABG-30-33-29-28-22-40-30-20-100LDL-CStrokeTotalmortality% *Confidence interval (CI) not reported.95% CI, 14%-41%.95% CI, 16%-37%.95% CI, 12%-31%.Hebert PR et al. JAMA. 1997;278:313-321.Nonfatal/fatal CHDCVDmortalityPyrl K et al. Diabetes Care. 1997;20:614-620.0.500.600.700.800.
2、901.000.001.002.003.004.005.000123456Proportionwithoutmajor CHD eventYr since randomization- P=0.002- P=0.0001Diabetic, simvastatinDiabetic, placeboNondiabetic, simvastatinNondiabetic, placebo32%55%Haffner SM et al. Diabetes. 1998;(suppl 1):A54. Abstract.-46-56-40-43-60-50-40-30-20-100Totalmortality
3、CoronarymortalityMajorcoronaryeventsRevas-culari-zations inevents(%)P=0.005P=0.001P=0.010Acute coronaryeventNo history of CADAcute Coronary Syndromest=0Randomization:CARE - 320 moLIPID - 336 moRandomization:6 moStable CAD71249-275-16-50-40-30-20-1001020TCHDL-CTGPlaceboAtorvastatin 80 mg% Data from S
4、chwartz GG et al. JAMA. 2001;285:1711-1718.Additional data courtesy of GG Schwartz.unstable anginaor nonQ-wave MI3,086randomized2496 hafter admissionFollowed 16 weeks0510150481216Time since randomization (wk)Cumulativeincidence(%)RR = 0.84(95% CI, 0.70-1.00) P = 0.048AtorvastatinPlacebo17.414.8*Deat
5、h (any cause), nonfatal MI, resuscitated cardiac arrest, recurrent symptomatic myocardial ischemia with objective evidence requiring emergency rehospitalization.Schwartz GG et al. JAMA. 2001;285:1711-1700.751.001.252.00Relative riskDeathNonfatal MIResuscitatedcardiac arrestNo. (%) of event
6、s*Adapted from Schwartz GG et al. JAMA. 2001;285:1711-1718.0.00.51.01.52.00481216Time since randomization (wk)RR = 0.50(95% CI, 0.26-0.99)P = 0.045Placebo1.6Cumulativeincidence(%)Data from Schwartz GG et al. JAMA. 2001;285:1711-1718.19,599 men and women 80 yo discharged post AMI, 58 Swedish Hospital
7、s, 1995-19985528 (28%) statin rx vs 14071 (72%) no statin rx, highest hospital rates of use 48%; lowest 12% Stenestrand JAMA 2001;285;430-436RR 0.75 (0.63-0.89)P=0.001 25% Risk ReductionHeeschen C et al. Circulation. 2002;105:1446-1452.051015202530181614121086420Follow-up (day)Event rates (%) Statin
8、s discontinuedNo statinsStatins continued507090110130150170190210TNT 80mgTNT 10 mgCARE-SLIPID-S4S-SCARE-PLIPID-PTNT Entry4S-PAVERT 80mg: LDL=77 mg/dL13.4% Event RateIIIa IIbIII=ACC/AHA Practice GuidelinesACC/ AHAUA/ NSTEMIGuidelines 2002Risk ratio and 95% CISTATINPLACEBOBaselinefeature(10269)(10267)
9、STATIN betterSTATIN worseSTATIN worsePrevious MI10071255Other CHD (not MI)452597No prior CHD CVD182215PVD332427Diabetes279369SE 2.6(2P0.00001)1.01.21.4Risk ratio and 95% CISTATINPLACEBOBaselinefeature(10269)(10267)STATIN betterSTATIN worseLDL (mg/dl)Hetc22= 0.8 100 130670881 13010875ALL PAT
10、IENTS20422606(19.9%)(25.4%)SE 2.6(2P0.00001)1.01.21.4(2.6 mmol/l)(3.4 mmol/l)01020300123456Proportion withevent (%)Years of follow-upBenefit/1,000 (SE)5 (3)20 (4)35 (5)46 (5)54 (7)60 (18)Logrank P 0.0001PlaceboSimvastatin 2002 Thomson Professional Postgraduate SHPS Col
11、laborative Group. Lancet. 2002;360:7-22.ARR=absolute risk reduction; NNT=number needed to treat. 2002 Thomson Professional Postgraduate SHPS Collaborative Group. Lancet. 2002;360:7-22.HPS enrolled high-risk primary- and secondary-prevention patients.HPS. Lancet. 2002;360:7. Dow
12、ns. JAMA. 1998;279:1615.LIPID. N Engl J Med. 1998;339:1349. Sacks. N Engl J Med. 1996;335:1001. 4S. Lancet. 1995;345:1274. Shepherd. N Engl J Med. 1995;333:1301. % with CHD eventMean LDL-C level at follow-up (mg/dL)05101520253090110130150170190210CARE-RxLIPID-Rx4S-RxCARE-PILIPID-PI4S-PI2 Prevention1
13、 PreventionWOSCOPS-PIWOSCOPS-RxAFCAPS-RxAFCAPS-PIHPS-PlHPS-RxHPS-RxHPS-Plw/revasc+stroke CHD onlyPI=placebo Rx=treatment70 2002 Thomson Professional Postgraduate SDowns JR, et al. JAMA. 1998;279:1615.012345678LovastatinPlacebo 34 403539HDL-C Tertile (mg/dL)Events, % *P0.01; P=0
14、.006; P=0.05P=placebo group; Rx=treated group.Presented by HB Rubins at the 71st annual AHA Scientific Sessions; Dallas, Texas.Subjects: 2,531 menAge: 74 (avg 64) yrMean baseline LDL-C: 111 mg/dLMean baseline HDL-C: 32 mg/dLMean baseline TG: 161 mg/dLDuration: 7 yrIntervention: Gemfibrozil 600 mg bid47.5-24.5-22-21-27-10-30-25-20-15-10-50510%+*LDL-CHDL-CTGNonfatal MI/CHD deathCHDdeathAll-causemortalityStrokeBrown BG, et al. N Engl J Med. 2001;345:1521.414.3051015202589%Reduction*P .05 vs placeboPlacebo S + NAVS + N + AVPearson TA, et al. Arch Intern Med. 2000;160:459.04080P
温馨提示
- 1. 本站所有资源如无特殊说明,都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
- 2. 本站的文档不包含任何第三方提供的附件图纸等,如果需要附件,请联系上传者。文件的所有权益归上传用户所有。
- 3. 本站RAR压缩包中若带图纸,网页内容里面会有图纸预览,若没有图纸预览就没有图纸。
- 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
- 5. 人人文库网仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对用户上传分享的文档内容本身不做任何修改或编辑,并不能对任何下载内容负责。
- 6. 下载文件中如有侵权或不适当内容,请与我们联系,我们立即纠正。
- 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
最新文档
- 期末测试(三)(原卷版+解析)-2020-2021学年七年级数学上册期末考点复习强化训练(沪科版)
- c 八皇后课程设计
- 三维设计课程设计
- 煤制乙二醇课程设计
- 工业管道课程设计书
- 抚州市乐安县2025届三上数学期末监测试题含解析
- 电子课程设计实验箱
- 吉林省延边朝鲜族自治州延吉市2024-2025学年数学三上期末达标检测试题含解析
- 新进厂员工安全培训试题及解析答案可打印
- 部门安全培训试题及解析答案
- 病毒性心肌炎
- 土木工程材料全套
- 环保责任制度
- 2023-2024学年安徽省滁州市小学数学六年级下册期末高分预测考试题
- YS/T 616-2006陶瓷过滤机
- GB/T 19995.1-2005天然材料体育场地使用要求及检验方法第1部分:足球场地天然草面层
- GB/T 15227-2019建筑幕墙气密、水密、抗风压性能检测方法
- DB42T 1958-2023 单轨道山地果园运输系统技术规程
- 冶金行业炼钢厂安全检查表
- 学校体育学(本科教学) 首都体育学院周登嵩教授
- CB/T 3780-1997管子吊架
评论
0/150
提交评论