糖尿病与恶性肿瘤相关性研究的新进展

1、2010年全球范围内有2.85亿糖尿病患者，这一 数字在未来20年内预期将达到4.39亿1。与此同时, 近年癌症的发病率和病死率呈现逐步上升的趋势2。 目前，糖尿病导致恶性肿瘤发病率增加的确切机制仍 不清楚。高血糖、高胰岛素血症、胰岛素样生长因子 -1受体、免疫系统等因素可能在糖尿病并发恶性肿瘤 中起着重要作用。1糖尿病与恶性肿瘤的关系1.1糖尿病与结直肠癌大量研究表明：糖尿病与结 直肠癌关系密切。邵琦等研究了 90 869例患者后分 析发现，糖尿病患者结直肠癌发生率较对照组高，且 差异有统计学意义(or: 1.43； 95%ci： 1.291.60)。 deng等在medline和embas

2、e进行meta分析，该 研究包括8个病例对照，16个队列研究，共3659 341 例志愿者的荟萃分析指出，与非糖尿病患者相比，糖 尿病患者结直肠癌发病危险性显著增加(rr=1.61, 95% ci 1.181.35)。1.2糖尿病与胰腺癌近年来，临床研究发现，糖尿 病是胰腺癌发生的独立危险因素。季尚玮等5将胰腺癌患者及非肿瘤患者分成糖尿病组和非糖尿病组，研 究糖尿病与胰腺癌的关系，结果发现：与非糖尿病组 比较，糖尿病患者患胰腺癌的or值为27.26(p6 ben q,xu m, ning x,et al.diabetes mellitus and risk of pancreatic canc

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