ThePhysicsofRadiologychapter61放射物理英文版

1、1会计学ThePhysicsofRadiologychapter61放放射物理英文版射物理英文版four Rs the repair of sublethal damagerepopulation by surviving cells in the irradiated tissuesredistribution of cells throughout the division cyclereoxygenation of hypoxic cellsInitial EventThe Passage of the Charged Particles EFFICIENCY of RADIATION

2、DAMAGE TRACKS of CHARGED PARTICLES DISTRIBUTIONS IN SPACE of ENERGY RELEASES LINEAR ENERGY TRANSFER (LET) the electron tracks 0.25 keV/m an alpha particle 250 keV/m SPECTRUM OF LET VALUES velocity charge IMMEDIATE RADIOCHEMICAL EFFECT Production of Solvated Electrons and RadicalsaqheOHeOHOH222HOHOH2

3、OHHOHOHh22Dependence of Radiation Damage on LET the radiobiological equivalent (RBE) the relative efficiency of killingASSAYS FOR PROLIFERATIVE CAPACITYSURVIVAL CURVES COLONY ASSAY METHODIN VITRO IN VIVO ASSAYS spleen-colony method Limiting dilution assayIn situASSAYS FOR PROLIFERATIVE CAPACITYSURVI

4、VAL CURVES COLONY ASSAY METHODIN VITRO IN VIVO ASSAYS spleen-colony method Limiting dilution assayIn situMATHEMATICAL ASPECTS OF SURVIVAL CURVES SINGLE HIT SURVIVAL CURVE dDNDdN010/0DDeNNThe mean lethal dose (D0) is the dose required to reduce the population of entities from any value N to 0.37 N MU

5、LTI-TARGET SINGLE HIT SURVIVAL CURVE )1 (1 0/0nDDeNNTHERAPEUTIC RATIO where D2 is the dose that leads to serious complications in 50% of the patients D2/D1and D1 is the dose that gives tumor control inthe same % of patients. RADIOBIOLOGICAL EQUIVALENT (RBE) RBE =Dose from standard radiation to produ

6、ce a given biological effectDose from the test radiation to produce the same biological effectCELL CYCLE AND RADIOSENSITIVITY four Rs EFFICIENCY of RADIATION DAMAGE TRACKS of CHARGED PARTICLES IMMEDIATE RADIOCHEMICAL EFFECT ASSAYS FOR PROLIFERATIVE CAPACITYSURVIVAL CURVES MATHEMATICAL ASPECTS OF SURVIVAL CURVES THERAPEUTIC RATIO RADIOBIOLOGICAL EQUIVALENT (RBE) CELL CYCLE AND RADIOSENSITIVITY Dependence of Radiation Damage on LET the radiobiological equivalent (RBE) the relative efficiency of killingTHERAPEUTIC RATIO where D2 is the dose that leads to serious com