羧甲基纤维素（Carboxymethyl cellulose）

1、羧甲基纤维素（Carboxymethyl cellulose）Carboxymethyl celluloseContent analysis; toxicity; limits of use; food additives; maximum permissible use; maximum permissible residue; standard carboxymethylcellulose; reagent grade pricesCarboxymethyl cellulose CAS: 9004-32-4English Name: Carboxymethyl celluloseEngli

2、sh synonyms: B10; cmc2; s75m; 7h3sf; carbo; cmc7h; cmc7m; cmc41a; cmc4h1; cmc4m6Carboxymethyl celluloseChinese synonym: cellulose gum; acid methyl cellulose; carboxymethyl cellulose; sodium carboxymethyl cellulose; carboxymethyl cellulose; sodium carboxymethyl cellulose; carboxymethyl cellulose sodi

3、um carboxymethyl cellulose; 1M6; sodium carboxymethyl cellulose (alkaline); carboxymethyl cellulose (IM6)CBNumber: CB5209844Molecular formula: C6H7O2 (OH) 2CH2COONaMolecular weight: 0MOL File: Mol fileCarboxymethyl cellulose, chemical propertyMelting point: 274 degrees C (Dec.)Density: 1,6 g/cm3Solu

4、bility: H2O:, 20, mg/mL, solubleForm: low viscosityWater solubility: solubleMerck: 141829Stability: Stable., Incompatible, with, strong, oxidizing, agents.EPA chemical information: Cellulose, carboxymethyl, ether, sodium, salt (9004-32-4)security informationDangerous category code: 40Safety instruct

5、ions: 24/25WGK Germany: 1RTECS: FJ5950000F: 3Carboxymethyl cellulose MSDSCarboxymethyl celluloseProperties, uses and production process of carboxymethyl celluloseContent analysisThe percentage of sodium carboxymethyl cellulose is reduced by 100 by subtracting the percentage of the following sodium c

6、hloride and sodium glycolate.The content of sodium chloride is accurate. Take the sample about 5g, remove a 250m1 beaker, add water 50ml and 30% hydrogen peroxide 5ml, heat 20min on the steam bath, and stir occasionally until completely dissolved. Cooling, using silver sulfate and mercury sulfate po

7、tassium sulfate electrode, do not stop stirring, add water 100ml and nitric acid 10ml, and then use 0.05mol/L silver nitrate titration to the end of the potential. Press the formula to calculate the percentage of sodium chloride in the sample:(584.4Vc) / (100-6) Omega, in which V and C are the consu

8、mption of silver nitrate (M1) and concentration (mol/L); 6 is the measured loss of weight; Omega is the mass of the sample (g); and 584.4 is the molecular weight of sodium chloride.The content of sodium glycolate is accurate. The sample is about 500mg and transferred into a 100ml beaker. First, the

9、5ml glacial acetic acid is then wetted with 5ml water, and then stirred to a solution with a glass rod (usually 15min). Slowly add acetone 50ml under agitation, then add sodium chloride, 1g, stirring for a few minutes to make sodium carboxymethyl cellulose all precipitate. The soft coarse filter has

10、 a hole with a small amount of acetone wetted, the filtrate collected in a volumetric flask of 100ml, another 30ml acetone residue and leaching residue move filter paper, then diluted with acetone after constant volume mixing.Prepare standard liquid according to the following: accurately take the gl

11、ycolic acid 100mg overnight in the dryer at room temperature, transfer to a 100ml capacity bottle, dissolve in water, and mix at definite volume.The fluid should be used within 30 days. Transfer the liquid 1.0., 2, 3 and 4.0m1 into four 100ml volumetric flasks, add water to about 5ml, then 5ml with

12、glacial acetic acid, and dilute with acetone.Take the sample liquid 2.0ml and each standard liquid 2.0ml, then move into five 25ml volumetric bottles, and then add a blank bottle containing 5% 2.0ml of acetone, which is composed of glacial acetic acid and water. Do not affix the capacity bottles to

13、20min in the boiling water bath to remove acetone, remove and cool. Each bottle of each 2, 7- dihydroxy naphthalene solution (TS-85) 5.0ml, a strong mixture plus 15ml, and strong mixing. Take thin aluminum cover. Place the volumetric flask vertically in a boiling water bath and keep 20min. Then remo

14、ve it, cool it, and mix it with sulphuric acid.With a proper spectrophotometric meter, with the blank solution for comparison, absorbance at 540nm was measured by liquid, draw the standard curve according to the standard absorbance, then according to the standard curve and the absorbance of samples

15、obtained in the sample quality glycolic acid (mg), and then press the calculate sampletoxicityADI does not make special provision (FAO/WHO, 2001).LD50 (rat, oral) 27g/kg.GRAS (FDA, 182.17452000).Use limitGB 2760-96 (g/kg): 5 - 1.2 instant noodles; solid beverage; popsicles, ice cream, cakes, biscuit

16、s, jelly, puffed food, GMP.FAO/WHO (1984, g/kg), sardines, mackerel, instant soup broth 20; 4000 mg/kg; cottage cheese, whipped cream 5, melted cheese 8, flavor mayonnaise 5000rag/kg.Maximum allowable use of food additives maximum allowable residue levelAdditive Chinese name allows the Chinese name,

17、 additive function, maximum allowable use (g/kg), maximum permissible residue (g/kg) of the food in this additiveSodium carboxymethyl cellulose food thickener needs proper use (except with special provisions)Sodium carboxymethyl cellulose beverages (except packaged drinking water) thickener 5Chemica

18、l propertyWhite or pale yellow fibrous powder; odorless and tasteless. Easy to disperse in water, become transparent colloid, insoluble in ethanol, acetone and ether and other organic solvents. Moisture absorption, 1% of the aqueous solution, Ph value of 6.5 8. When the temperature rises, the viscos

19、ity decreases, the browning temperature is 226228, and the carbonization temperature is 252253. The mice were orally given LD5027g/kg and ADI without special regulations (FAO/WHO, 1994).purposeAs an emulsifying stabilizer and thickener. The provisions of China can be used for instant noodles, the ma

20、ximum usage of 5g/kg; in the beverage (excluding solid beverage) in the maximum capacity of 1.2g/kg; in the biscuits, puffed food, popsicles, ice cream, cakes and jellies, according to production needs appropriate use.purposeThickening agent, stabilizer, tissue modifier, gelling agent; non nutritive

21、 leavening agent; moisture movement control agent; foam stabilizer; reducing fat absorption.Due to its adhesiveness, stability, protection of colloid and film formation, it is used for ice cream to improve water retention and tissue structure (0.3% 0.5%). But with sodium alginate and so on.For fast

22、cooking makes the product structure improvement, uniform, easy to control water,Easy operation.Add in cream, jam, peanut butter, can improve the workability. The amount of jam and sauce is from 0.5% to 1%.Add 0.1% of bread, cake and so on to prevent moisture from evaporating and aging.It is also use

23、d as a solid agent for powder, oil, perfume and so on. Its dosage is 20% 60% (CMC water solution, mixing human fat, spice and so on, fully emulsified, dried and crushed).Foam stabilizer for beer.Fruits, eggs and so on are coated and dried with 2% 3%CMC solution containing benzoic acid ester, so as t

24、o preserve flavor and mould. After water absorption, expansion is strong, not digest, used for biscuits and so on, can be made to lose weight food.purposeIt is widely used as thickening agent, suspending agent, binder and protective colloid in medicine, daily chemical and food industrypurposeUsed fo

25、r oil drilling, textile printing and dyeingpurposeUsed in oil and gas drilling mud stabilizer, textile slurry, paper strengthening agent, adhesive and so onpurposeUsed for washing, cigarette, building and daily chemical industrypurposeUsed for textile sizing, drilling, etc.purposeAs a water-based dr

26、illing fluid filtrate reducer, it has a certain viscosity increase effect.purposeIt can be used as a reinforcing agent in pulp, and is also used for surface sizing. It is used as viscosity modifier in coated paper.purposeThe most important use of CMC is the preparation of soaps and synthetic deterge

27、nts. Approximately 1% of the CMC is added to the heavy detergent to prevent the washing of the contaminants from being deposited on the fabric. The second is used as suspension stabilizer in petroleum industry drilling mud, as additive can improve the longitudinal strength and paper smoothness in pa

28、permaking industry, paint can improve the printing adaptability, used as thickening agent, emulsion stabilizer and ice cream ice inhibitor in food industry; used as a thickening agent, dyeing agent pulp slurry in the textile industry in the pharmaceutical industry; binder emulsion stabilizer, the ta

29、blet can be used for injection and the film forming agent; used as a thickening agent in the production of cosmetics, ceramics etc. Toxicity tests on CMC showed that the oral and skin contact had no physiological activity at all, and the toxicity was not found even after the oral dose of 10g/kg was

30、taken by the mice. The FAO and the WHO special committee also confirmed the safety of the product and stipulated that the persons daily intake (ADI) was 0-30mg/kg.Production methodsCarboxymethyl cellulose is produced by reacting cellulose with sodium hydroxide to produce alkali cellulose, which is t

31、hen prepared by decarboxylation with chloroacetic acid. System of law can be divided into water as the reaction medium water solvent method and reaction in isopropanol, ethanol and acetone as solvent in solvent method.Production methodsThe refined cotton, caustic soda, alcohol mixture, chloroacetic

32、acid alcohol solution modified with alkalization and etherification kneading machine. Then hydrochloric acid neutralization, alcohol washing, and then dried, crushed products.Production methodsImmerse the bleached bleached cotton in a proportion of 35% concentrated lye and soak for about 30 min. Liq

33、uid can be recycled. After soaking cotton short term called flat press, with 14 MPa pressure, extrusion lye, get alkaline cotton.Put the alkaline cotton into the etherification kettle, add 15 alcohol, add the chloroacetic acid alcohol solution slowly under the stirring,At 30 DEG C, 2 h is finished,

34、and after adding 3 h at 40 DEG C, the etherification cotton is obtained. Add alcohol (70%) 120 parts in the etherification cotton, stir 0.5 h, add salt acid, adjust pH value to 7. Wash it two times with alcohol, strain the alcohol, blow dry at 80, and smash the finished product.Low degree of substit

35、ution (0.4) and medium degree of substitution (0.4 - 1.2) can be produced according to different ingredient ratio.Production methodsThe cellulose is treated with sodium hydroxide to form alkali cellulose, mixed with sodium chloroacetate and processed for several days (2030 DEG C)Production methodsUs

36、ually refined cotton is used as raw material to react with sodium hydroxide to produce alkali cellulose, and then the product is prepared by decarboxylation with chloroacetic acid.(C6H9O4OH) n+nNaOH = (C6H9O4ONa) nClCH2COOH = (C6H9O4OCH2COONa) nThe process uses the traditional method with water as medium and water with organic solvent as reaction medium by solvent method.The traditional method of waterWith 18% 19% alkali water jet kneading machine, the purified cotton is alkaline under 3035 DEG C to produce alkali cellulose. Then, the solid sodium chloride is used for kneading and