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1HPLC法测定阿普唑仑片的含量A1A0A1A0A4A2A3A5HPLCA6A7A8A9A10A11A12A13A14A9A10A11A12A15A16A17A18A6A19A20A21A22A23A24A25A26A27A28A25A29A30A31A31A32A33A34A35A31A31A36A29A31A37A19A38A39A40A41A42A43A44A45A46A47A28A48A42A43A49A50A51A25A35A52A53A42A43A50A49A51A33A52A54A55A56A57A58A59A60A61A62A63A30A30A30A31A64A54A23A42A43A65A66A67A68A69A35A34A30A37A70A71A72A50A73A74A28A35A30A75A76A29A75A29A37A54A38A77A41A25A34A30MLMIN1A36A78A7A79A80A63A63A63A81A31A54A82A83A6A8A16A54A7A8A9A10A11A12A17A15A16A19A84A85A84A85A9A10A11A12A86A29A87A76A29GML1A88A89A90A91A92A54A93A94A95A96A97A98A28A99A69A30A34A100A100A100A100A100A37A54A101A102A103A104A105A106A28A100A100A34A100A107A37A19A84A108A84A108A109A6A110A111A112A113A54A114A115A94A97A98A54A18A6A116A117A118A119A19A120A121A122A120A121HPLCA9A10A11A12A13A9A10A11A12A15A16DETERMINAITIONOFALPRAZOLAMTABLETSBYHPLCABSTRACTOBJECTIVEAHPLCMETHODFORTHEDETERMINATIONOFALPRAZOLAMTABLETSWASESTABLISHEDMETHODSAZORBOXSBC18COLUMNWASUSED,WITHTHEMOBILEPHASEOFPHOSPHATICBUFFERWEIGHUPPOTASSIAMDIHYDROGENPHOSPHATE16GANDPOCASSIUMPHOSPHATEDIBASIC4G,DISSOLVEDTHEMINWATERANDDILUTEDTO2000ML,PH60,ADUJUSTEDWITHPHOSPHORICACIDACETONITRILETETRAHYDROFURAN60505,ATTHEFLOWRATEOF10MLMIN1,THEDETECTIONWAVELENGTHWAS222NMRESULTSTHELINEARRANGEOFALPRAZOLAMTABLETSR099999WAS535GML1,THEAVERAGERECOVERYOFALPRAZOLAMTABLETSWAS999RSD05CONCLUSIONITWASACCURATEANDRAPIDKEYWORDSA123HPLCA124ALPRAZOLAMTABLETSA124ALPRAZOLAMA124DETERMINATIONA125A126A127A128A129A130A131A132A133A134A135A136A137A138A139A140A141A137A125A142A143A144A145A140A141A146A147A148A146A149A150A151A152A153A144A145A133A134A154A140A141A155A156A157A144A137A125A158A159A160A161A162A163A164A165A166A167A168A169A170A171A172A173A174A175A176A177A178A179A180A181A182A183A184A185A186A187A188A189A190A191A159A192A193A194A194A195A186A196A197A198A179A199A200A187A188A201A202A203A204A186A183A184A205A206A207A208A209A210A181A182A166A167A211A189A190A191A159A192A193A194A194A195A186A212A213A214A215A216A166A217A218A219A220A179A199A186A221A160A222A223A224A225A226A172A227A224A228A229A179A230A231A232A233A234A235A231A232A233A2342A236A237A236A238A239A240A241A242A243A244A245A238A246A247A248A249A250A251A252A253A254A254A255A255A89A0A178A254A1A254A2A247A240A99A3A242A4A49A247A248A249A250A251A252A253A254A254A255A255A89A0A178A254A1A254A5A247A149A6A7A8A239A49A247A248A249A250A251A252A253A254A254A255A255A89A0A178A254A1A254A9A247A23A10A11A49A247A248A249A250A251A252A253A184A12A13A14A15A112A188A16A150A2A5A255A254A58A17A149A6A18A19A19A20A21A191A192A22A24A25A26A27A197A236A237A28A198A29A246A30A31A32A33A34A35A36A37A38A39A254A255A255A40A255A41A42A43A44A29A36A45A46A47A36A7A48A50A49A206A207A208A254A51A254A2A254A52A150A2A255A255A9A255A1A53A49A65A54A55A244A245A56A49A57A59A60A61A62A127A57A59A61A60A62A127A67A61A63A64A127A57A59A55A18A152A56A49A66A55A56A184A66A49A30A31A32A33A68A191A206A207A55A255A9A254A254A254A255A255A69A255A127A255A51A254A254A254A255A255A51A255A127A255A51A254A254A254A255A254A255A255A197A55A22A26A27A195A36A70A28A71A72A73A74A75A72A73A74A75A2A40A254A244A245A170A76A244A245A23A246A215A77A253A251A252A78A150A17A79A80A244A245A23A37A254A69A255MMA81A5A40A9MMA42A69A82A53A112A83A84A243A246A57A59A85A86A87A242A37A88A57A59A60A61A62A254A9A248A90A57A59A61A60A62A5A248A49A91A66A92A93A94A95A96A97A2A255A255A255A82A250A49A98A57A59A100A101A102A103A104A9A40A255A53A65A54A67A61A63A64A37A9A255A246A1A69A246A69A53A112A7A8A105A106A246A2A2A2A252A82A112A23A10A246A1A69A218A112A157A107A39A246A2A255A174A108A199“A109A110A111”A113“A109A110A114”A220A115A116A117A118A119A120A199A121A122A223A123A121A124A125A126A224A128A129A114A130A174A126A225A131A132A133A134A135A134A111A136A108A228A137A138A139A140A109A110A141A142A143A144A145A126A232A146A147A148A151A153A154A114A130A130A130A108A114A110A114A124A125A155A118A119A114A110A114A110A111A120A199A121A124A125A155A118A119A156A158A159A160A161A162A163A164A120A199A121A165A166A126A167A168A169A171A118A172A114A130GML1A173A175A176A177A179A180A181A182A183A182A183A182A185A186A177A179A180A173A187A189A190A193A177A194A196A200A201A202A203A204A205A201A242A209A201A202A203A204A190A210A211A212A244A213A214A216A217A219A221A222A182A226A227A229A246A194A196A196A226A230A211A231A233A234A235A236A213A210A211A201A248A237A238A239A240A241A243A201A234A235A236A213A245A247A249A250A251A201A253A252A201A254A196A183A255A240A27A15A2A0A1A3A1A4A49A7A5A17A6A8A935041A6A8A9035013A172A10A111A12A13A14A16AA18A19A20A14A16BA18A21A22A23A24A25A26A28FIG1CHROMATOGRAMSOFREFERENCESUBSTANCEA16AA18ANDSAMPLEA16BA181A29A30A31A32A16ALPRAZOLAMA18A58A33A34A86A35A36A37A38A39A143A40A41A42A43A44A45A46A47A48A50A51A52A53A54A246A52A55A53A56A57A59A60A61A62A63A64A65A61A248A66A67A68A69A70A71A72A73A74A61A253A75A61A222A76A77A143A40A57A42A78A79A47A48A50A67A159A55A80A52A61A81A80A55A61A81A80A52A61A51A80A55A61A51A80A52A61A82A80A55A61A82A80A52A53A56A152A83A246A52A55A53A84A57A59A60A61A76A63A64A65A70A71A72A73A74A61A253A75A61A224A85A87A51A55A56A61A88A78A79A170A89A90A91A92A93A61A94A47A48A50A95A74A96GML1A97A137A98A99A100A101A102A103A104A105A137A106A99A100A101A107A204A100A108A109A110A111A112A113A114A115A137A116A117A11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