点阵CO2激光论文：点阵CO_2激光联合积雪苷霜软膏治疗痤疮凹陷性瘢痕疗效观察.doc

点阵CO2激光论文：点阵CO_2激光联合积雪苷霜软膏治疗痤疮凹陷性瘢痕疗效观察【中文摘要】选用点阵CO2激光联合积雪苷霜软膏的方法治疗痤疮凹陷性瘢痕,旨在评价联合治疗对痤疮凹陷性瘢痕的临床疗效和安全性,掌握点阵激光的临床适应证及应用技巧,探索一种安全性高、疗效可靠、误工期短、适宜推广的治疗痤疮瘢痕的新方法。方法：所选40例患者均为2009年12月至2011年03月江苏省中医院皮肤科门诊患者,随机将40例患者分为两组,点阵C02激光联合积雪苷霜软膏组为治疗组,单一点阵C02激光组为对照组,每组各20例,两个月左右治疗一次,两次为一个疗程。遵循B.Dreno的ECCA权重评分表,根据痤疮瘢痕的性状和密集程度进行权重评分,观察两次治疗后皮损变化情况并作出评分,记录治疗中和治疗后所出现的不良反应及持续时间,从而做出疗效评价及安全性评价。结果：1.治疗组有效率75%,对照组有效率65%,两组总有效率比较,差异无统计学意义(P=0.4900.05)；2.治疗组误工期为7.893.39天,对照组误工期为10.583.90天,治疗组明显低于对照组,有统计学意义(P=0.03 0.05);2.Delays of working time of the treatment group was 7.893.39 days, Delays of working time of the control group was 10.583.90 days, the treatment group was significantly lower than the control group.It is statistically significant (P=0.030.05);3. Regardless of treatment group or control group, The effectiveness with two times treatment is better than the effectiveness with two times treatment.4. The common untoward effect which discovered in the course of treatment include:redness, burning, mild pain, the probability is 100%; The rare untoward effect include:Pigmentation 1 example, durable blood flushes 1 example, infectious pus blister 3 examples. The serious untoward effect is not seen.Conclusion:The study confirmed the way of combining Fractional CO2 Laser and Centella Triterpenes Cream to treat face atrophic acne scar is effective.The clinical efficacy is Similar to the single Fractional CO2 Laser treatment, but the delays of working time is shortened in the treatment group.No serious adverse reflection of the two groups. This shows that the Fractional C02 Laser in the treatment of atrophic acne scars is safe and effective.The Centella Triterpenes Cream can effectively reduce the delays of working time,It is worth promoting.【关键词】点阵CO2激光 积雪苷霜软膏 痤疮凹陷性瘢痕 疗效观察【英文关键词】Fractional CO2 Laser Centella Triterpenes Cream atrophic acne scar efficacy【目录】点阵CO_2激光联合积雪苷霜软膏治疗痤疮凹陷性瘢痕疗效观察摘要7-8Abstract8-9前言10-11第一部分 文献综述11-181. 中医对瘢痕的认识11-131.1 病因病机研究111.2 治疗研究11-132. 现代医学对瘢痕的认识13-152.1 瘢痕的分类132.2 瘢痕的发病机制13-153. 痤疮凹陷性瘢痕的治疗进展15-183.1 药物治疗15-163.2 微晶磨削治疗163.3 自体颗粒脂肪移植163.4 激光治疗163.5 其他方法16-173.6 当前治疗趋势17-18第二部分 临床研究18-261. 研究背景及目的182. 一般资料18-192.1 两组性别比较182.2 两组年龄比较18-192.3 两组病程比较192.4 两组治疗前ECCA评分比较193. 研究方法19-213.1 诊断标准193.2 病例纳入标准19-203.3 病例排除标准203.4 病例剔除标准203.5 病情分级评分标准203.6 误工期及不良反应203.7 试验病例的终止20-213.8 试验病例的脱落与处理214. 治疗方案21-224.1 试填写病例记录表214.2 仪器及药物214.3 分组治疗214.4 试验步骤21-225. 数据及统计225.1 数据采集时间225.2 采集方法225.3 疗效标准225.4 资料整理与统计分析226. 结果22-266.1 治疗前后ECCA评分比较22-236.2 两组疗效比较23-246.3 两组安全性指标比较24-26第三部分 讨论26-311. 关于点阵激光26-271.1 点阵激光在痤疮凹陷性瘢痕中的应用261.2 点阵激光在其它疾病中的应用26-271.3 点阵激光治疗时的注意事项及不良反应272. 关于积雪苷霜软膏27-292.1 瘢痕疙瘩282.2 色素性皮肤病282.3 烧/烫伤创面28