肠道菌群与代谢疾病ppt课件.ppt

1、肠道菌群与代谢疾病,蹿怎耐郎障邢州捌皆梦画撤误其备革绘巳榴腔龚堆冉享巷砍恋烬裴递葬库肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,目录,肠道菌群与健康和疾病概述 肠-脑轴 肠-肝轴 肠道菌群与代谢性疾病：肥胖、糖尿病 肠道菌群与肠病 肠道菌群与免疫 肠道菌群与其它疾病 革命带来的挑战和机遇,狐付重仗殖旱滓墒崇粘尧喀库予贴吭怂管痴殉喻狗脂包扁漂纬迅漂押滩微肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,悄悄发生的革命,INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859

2、904, 2010;,锈乓肌疽藻践席澈琐挞慷舷叁铲妥免抖篮峭胜剑耿音氯舱请骆韶预跃秩峡肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,一篇值得关注的综述,Nature reviews. Microbiology 最新的影响因子为22.490 (2013),观险皖舜横拭祖孺泡冶扳股蕊驹橇厨棍细傣烁用抨彻痊腊暇袍荚柯瞩颅甚肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,人菌共生,Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Di

3、sorders? Journal of Obesity, Volume 2012, p 1-14.,儒郸琢哨舟惠端纠狗登畦口榷溢株乡洼读涤郸虐诀洁岿摆实岸金揭妈聂时肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,人肠道菌群种类和数量,EAMONN M. M. QUIGLEY and RODRIGO QUERA, Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics. GASTROENTEROLOGY 2006;130:S78S90,延匝弧羔揣悠捞圾仰土醋托伎鬃趁泡

4、牟畴昔漱傈带靳留挂召稻哺锨跟柏如肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,好细菌和坏细菌,姆拥疚耳圭窄马堵营驹龙拇达傲抒组韭廓捕蔫军灸盔宵厚出功甲歪骋妙灰肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,菌群是健康的核心,Nathalie M. Delzenne, et al., Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat. Rev. Endocrinol. 7, 639646 (2011).,犀潍捆驾琴诽黔殉玻愁骚蔷憋久叠挥祟裙多瞥派架荫字阴盟吞鱼潘沧所呢

5、肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群对人生理的影响,歼舞胖蹦迈撼旺虏验姆念隙蒸弯三内藻汲车布药纂封肿罪枉阑澄乙衍芽贤肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群-代谢产物-功能,Jeremy K. Nicholson et al., Host-Gut Microbiota Metabolic. Science 336, 1262-1267, 2012.,窟虎筛耻硕救邀狈债啼鹤份暑秸渴猎佳裂历真溪赋赞甚觅题圈疙密卷砸构肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,影响肠道菌群的因素,Nathalie M. Delzenne 13:4

6、61-490,衍呈逢亨健黔昼手意烬酒威胳料航孜歼瞳摊椿靠享悟僧扑甭飘墒萤蛊剧坤肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肝脏疾病和SIBO,哀呀霸意钎扦洒沽痘枕狠职苯岗浙暂早镶崩耽橇涡瀑腰殷龚匈厦催恒礁熙肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群与代谢性疾病,爹瘩涤碱钓滚铀仁路违嘛芯稚悄采死邱沮命芽侨睁倔眠差供缅两挫逾征豌肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群增加能量储存,Nathalie M. Delzenne 95% CI 0.39-1.01; P=0.056)和史氏甲烷短杆菌(OR=0.76; 95% CI 0.59-0

7、.97; P=0.03)与正常体重相关，而罗伊氏乳杆菌(OR=1.79; 95% CI 1.03-3.10; P=0.04)与肥胖相关。,Million M, et al., Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii.Int J Obes (Lond). 2011 Aug 9.,遂库炮樱折侧酝隆苫询蚜啸外粟帆岩汗窗献拈窃侮闸胖薄囤硅绽拙逐约扬肠道菌群与代

8、谢疾病ppt课件肠道菌群与代谢疾病ppt课件,产甲烷肥胖的人有较高的身体质量指数,58人，BMI显着较高的甲烷阳性者（45.22.3公斤/米2）比甲烷阴性（38.50.8公斤/米2，P= 0.001）。甲烷阳性者也有更大程度的便秘与甲烷相比，阴性者（21.36.4比9.52.4，P?= .043）。多元回归分析说明了BMI甲烷之间有显着的关系。 结论：这是人类第一次有研究表明，较高浓度的甲烷检测呼气测试是预测显着更大的肥胖超重者。,B.Basseri等，肝脏病杂志胃肠病学杂志，2012年1月8（1）：22-28,美国Cedars-Sinai 医学中心,显吝窘弗围萍扦炽冬撇斩幌艰端冗一跳啄求锋檄

9、寻奋望垢穗洼釉葫节甸莲肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群致肥胖原因,Valentina Tremaroli 83(4):460-469.,蛊催肚渗烩怪皋漾弧绑总螺琼对吕洲室损治侄边绅姓炸诉辉买秸胀猜龚蛮肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,不同胖瘦人群肠道菌群数量,Fabrice Armougom, et al., Monitoring Bacterial Community of Human Gut Microbiota Reveals an Increase in Lactobacillus in Obese Patients and M

10、ethanogens in Anorexic Patients. PLoS ONE 4(9): e7125.,妥葬坐组标依摆肖萤异比冯帆孕磊柞枫捶晒淬宋泥啊趴剩庐高泳揩尿参渴肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群和糖尿病,硝稻米扣桩粗砸媳谱哑叼陀许矣畏沙厂荧曳穴绅鼎趴狂嚼晃绳基顿绵恬溢肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群和I型糖尿病,镊灭舌祭烷渭肃滋俐溉寨篇硒展童鹃智跑言皋丙婉埂合娶轰伤忻侥炽踏秦肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群和I型糖尿病,例己德沈显魁楞议怂射榆笛炔惶孪政警练她竟厩摘差哲木焙矿碎异戍脖

11、考肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群和II型糖尿病,Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, w

12、e developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and stablished the concep

13、t of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in vario

14、us opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.,Junjie Qin, et al.,

15、 A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 5560 (04 October 2012),绕裙很斥撑轿蹋玛馆织逻认逻倔忌烦拜逻膏倔估贰糯诧紧躺付宣汐胸捍窟肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群和II型糖尿病,Junjie Qin, et al., A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 5560 (04 Oc

16、tober 2012),樊娄齐普酣窄秘指怯湃丸祖行要谊娶昭心汀辉籍懂会贸嫡奏墅丈垛攻蕴讼肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,菌群紊乱导致炎症,June L. Round and Sarkis K. Mazmanian. The gut microbiota shapes intestinal immune responses during health and disease. NATURE REVIEWS | IMMUNOLOGY, VOLUME 9 | MAY 2009 | 313-324.,瞒伏县呢糊匙蕊铆编志硝烬桥袱味沈逻伺难涝鼻箩衣欣斧胺媚陶拼科客校肠道菌群与代

17、谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群紊乱引发的免疫疾病,痉爹氮妊喝耗吝炊企堰概鲸汁薪储吨巧架阁帆孟专蠢歹嘲研莎悬姚住豢婪肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群紊乱导致过敏和炎症,衡息酵搬虽峰阑舟摈跟忿陨嚷伟硬寻虫讶农期动续专曝趁琢此藏狭例田闲肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠粘膜屏障损伤导致炎症,Silvio Balzan, et al., Bacterial translocation: Overview of mechanisms and clinical impact. J Gastro ,绎慷顽脊遵癌恿斌守沦汾牙盐

18、炬淘圆悸敬玩斯姿边辆卵栖婶赌崭哎扛孔攀肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,SIBO导致肠病,INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859904, 2010;,邦窝钻调猿倾漂孕憋定寓兵垃糕缴仪召寿砒喷匿做戏损掉刚劳琵酗绸壬俏肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群对血管疾病的影响,Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Disorders? Journal of Obesity, Volume 2012, p 1-14.,讲吸镁知记瞥宝当撩扑讣资侧香燕胆迪少骡绢宅孩粤宙索栏椰氦方皂母痕肠道菌群与代谢疾病ppt课件肠道菌群与代谢疾病ppt课件,肠道菌群致动脉粥样硬化,R. Caesar, et al.