Solamargine-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemESolamargine(Standard)Cat.No.:HY-N0069RCASNo.:20311-51-7分子式:C₄₅H₇₃NO₁₅分子量:868.06作用靶点:P-glycoprotein;P-glycoprotein;P-glycoprotein;P-glycoprotein;Apoptosis;Apoptosis作用通路:MembraneTransporter/IonChannel;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Solamargine(Standard)是Solamargine的分析标准品。本产品用于研究及分析应用。Solamargine是一种来源于茄属植物的类固醇Solasodine的衍生物，在多种癌症中均表现出抗癌活性。Solamargine诱导非选择性细胞毒性和P-gp抑制作用。Solamargine通过下调MMP-2和MMP-9的表达和活性来显着抑制HepG2细胞的迁移和侵袭。REFERENCESBurgerT,etal.Solamargine,abioactivesteroidalalkaloidisolatedfromSolanumaculeastruminducesnon-selectivecytotoxicityandP-glycoproteininhibition.BMCComplementAlternMed.2018May2;18(1):137.SaniIK,etal.Solamargineinhibitsmigrationandinvasionofhumanhepatocellularcarcinomacellsthroughdown-regulationofmatrixmetalloproteinases2and9expressionandactivity.ToxicolInVitro.2015Aug;29(5):893-900.DingX,etal.InductionofapoptosisinhumanhepatomaSMMC-7721cellsbysolamarginefromSolanumnigrumL.JEthnopharmacol.2012Jan31;139(2):599-604.FuR,etal.SolamargineinhibitsgastriccancerprogressionbyregulatingtheexpressionoflncNEAT1_2viatheMAPKsignalingpathway.IntJOncol.2019May;54(5):1545-1554.BurgerT,etal.Solamargine,abioactivesteroidalalkaloidisolatedfromSolanumaculeastruminducesnon-selectivecytotoxicityandP-glycoproteininhibition.BMCComplementAlternMed.2018May2;18(1):137.SaniIK,etal.Solamargineinhibitsmigrationandinvasionofhumanhepatocellularcarcinomacellsthroughdown-regulationofmatrixmetalloproteinases2and9expressionandactivity.ToxicolInVitro.2015Aug;29(5):893-900.DingX,etal.InductionofapoptosisinhumanhepatomaSMMC-7721cellsbysolamarginefromSolanumnigrumL.JEthnopharmacol.2012Jan31;139(2):599-604.FuR,etal.SolamargineinhibitsgastriccancerprogressionbyregulatingtheexpressionoflncNEAT1_2viatheMAPKsignaling1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEpathway.IntJOncol.2019May;54(5):1545-1554.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuse