N-Desmethylclozapine-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEN-Desmethylclozapine(Standard)Cat.No.:HY-G0021RCASNo.:6104-71-8分子式:C₁₇H₁₇ClN₄分子量:312.8作用靶点:mAChR;OpioidReceptor;DrugMetabolite;VirusProtease作用通路:GPCR/GProtein;NeuronalSignaling;MetabolicEnzyme/Protease;Anti-infection储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性N-Desmethylclozapine(Standard)是N-Desmethylclozapine的分析标准品。本产品用于研究及分析应用。N-Desmethylclozapine是非典型抗精神病有效剂Clozapine的主要活性代谢产物。N-Desmethylclozapine是一种有效的、变构的部分M1受体激动剂(EC50=115nM)，能通过M1受体激活增强海马N-methyl-d-aspartate(NMDA)受IC50&TargetEC50:115nM(M1receptors)[1]δ-opioid[2]REFERENCESLiZ,etal.N-desmethylclozapine,amajormetaboliteofclozapine,increasescorticalacetylcholineanddopaminereleaseinvivoviastimulationofM1muscarinicreceptors.Neuropsychopharmacology.2005Nov;30(11):1986-95.OdagakiY,etal.ComparativeanalysisofpharmacologicalpropertiesofxanomelineandN-desmethylclozapineinratbrainmembranes.JPsychopharmacol.2016Sep;30(9):896-912SugawaraY,etal.Electrophysiologicalevidenceshowingmuscarinicagonist-antagonistactivitiesofN-desmethylclozapineusinghippocampalexcitatoryandinhibitoryneurons.BrainRes.2016Jul1;1642:255-62GigoutS,etal.DifferentpharmacologyofN-desmethylclozapineathumanandratM2andM4mAChRsinneocortex.NaunynSchmiedebergsArchPharmacol.2015May;388(5):487-96HimmerichH,etal.Impactofclozapine,N-desmethylclozapineandchlorpromazineonthromboxaneproductioninvitro.MedChem.2012Nov;8(6):1032-8.MedigeshiGR,etal.N-Desmethylclozapine,FluoxetineandSalmeterolinhibitpost-entrystagesofdengueviruslife-cycle.AntimicrobAgentsChemother.2016Aug29.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820