Licochalcone-B-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemELicochalconeB(Standard)Cat.No.:HY-N0373RCASNo.:58749-23-8分子式:C₁₆H₁₄O₅分子量:286.28作用靶点:Amyloid-β;Apoptosis;NOD-likeReceptor(NLR)作用通路:NeuronalSignaling;Apoptosis;Immunology/Inflammation储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 LicochalconeB(Standard)是LicochalconeB的分析标准品。本产品用于研究及分析应用。LicochalconeB是从Glycyrrhizauralensis根中提取的。LicochalconeB抑制淀粉样蛋白β(amyloidβ;Aβ42)自聚集作用(IC50=2.16μM)并分解预先形成的Aβ42原纤维，通过螯合金属离子减少金REFERENCESCaoY,etal.LicochalconeB,achalconederivativefromGlycyrrhizainflata,asamultifunctionalagentforthetreatmentofAlzheimer'sdisease.NatProdRes.2018Oct22:1-4.Jun-ichiFurusawa,etal.Glycyrrhizainflata-derivedchalcones,LicochalconeA,LicochalconeBandLicochalconeD,inhibitphosphorylationofNF-kappaBp65inLPSsignalingpathway.IntImmunopharmacol.2009Apr;9(4):499-507.Ha-NaOh,etal.LicochalconeBinhibitsgrowthandinducesapoptosisofhumannon-small-celllungcancercellsbydualtargetingofEGFRandMET.Phytomedicine.2019Oct;63:153014.QiangLi,etal.LicochalconeBspecificallyinhibitstheNLRP3inflammasomebydisruptingNEK7-NLRP3interaction.EMBORep.2022Feb3;23(2):e53499.TengH,etal.HepatoprotectiveeffectsoflicochalconeBoncarbontetrachloride-inducedlivertoxicityinmice.IranJBasicMedSci.2016Aug;19(8):910-915.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>