UNC0638-hydrate-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEUNC0638hydrateCat.No.:HY-110093CASNo.:1255517-77-1分⼦式:C₃₀H₄₉N₅O₃分⼦量:527.74作⽤靶点:VSV;HistoneMethyltransferase;Autophagy;InfluenzaVirus作⽤通路:Anti-infection;Epigenetics;Autophagy储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性UNC0638hydrate选择性抑制G9a和GLP组蛋⽩甲转移酶，IC50分别为15nM和19nM。UNC0638hydrate在体外可抑制TNBC细胞的侵袭和迁移。UNC0638hydrate也EHMT1/2的抑制剂，在⼈红细胞祖细胞培养中诱导胎⼉⾎红蛋⽩(HbF)表达。此外，UNC0638hydrate具有抗FMDV(⼝蹄疫病毒)和抗VSV(⽔性⼝炎病毒)的活性，对多种表观遗传和⾮表观遗传靶标具有出⾊的效⼒和选择性。IC50&TargetIC50:[1]户使⽤本产品发表的科研⽂献•ProcNatlAcadSciUSA.2019Feb19;116(8):2961-2966.•CellChemBiol.2022Jun18;S2451-9456(22)00198-2.•ActaPharmacolSin.2021Apr13.•CellDeathDis.2018Jan26;9(2):129.•CellBiosci.2023Jan12;13(1):7.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].VedadiM,etal.AchemicalprobeselectivelyinhibitsG9aandGLPmethyltransferaseactivityincells.NatChemBiol.2011Jul10;7(8):566-74.[2].FuL,etal.EffectsoftheHistoneMethyltransferaseInhibitorUNC0638onHistoneH3K9DimethylationofCulturedOvineSomaticCells1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEandDevelopmentofResultingEarlyClonedEmbryos.ReprodDomestAnim.2014Apr;49(2):e21-5.[3].SinghN,etal.InhibitionofEHMT2InducesaRobustAntiviralResponseAgainstFoot-and-MouthDiseaseandVesicularStomatitis

VirusInfectionsinBovineCells.JInterferonCytokineRes.2016Jan;36(1):37-47.[4].LiuXR,etal.UNC0638,aG9ainhibitor,suppressesepithelial‑mesenchymaltransition‑mediatedcellularmigrationandinvasionintriplenegativebreastcancer[J].Molecularmedicinereports,2018,17(2):2239-2244.[5].NualkaewT,etal.UNC0638induceshighlevelsoffetalhemoglobinexpressioninβ-thalassemia/HbEerythroidprogenitorcells[J].Annalsofhematology,2020,99:2027-2036.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:4