Protoporphyrin-IX-disodium-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEProtoporphyrinIXdisodiumCat.No.:HY-B1247ACASNo.:50865-01-5分⼦式:C₃₄H₃₂N₄Na₂O₄分⼦量:606.62作⽤靶点:EndogenousMetabolite作⽤通路:MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性ProtoporphyrinIXdisodium⾎红素⽣物合成途径中的最终中间体。ProtoporphyrinIXdisodium作为辐射敏化剂，即使在缺氧状态下也能增强ROS的⽣成并诱导DNA损伤。ProtoporphyrinIXdisodium也作为光敏剂，通过光照射直接降解发⽣光漂⽩。ProtoporphyrinIXdisodium在给药5-aminolevulinicacid(5-ALA)(HY-W000450)后在⼤⿏肿瘤细胞中形成和积累。当激活峰值波长为405nm的红⾊荧光时，ProtoporphyrinIXdisodium引起底细胞癌的选择性改。ProtoporphyrinIXdisodium有望⽤于声动⼒和光动⼒对癌症的药物研究，如膀胱癌和结节性底细胞癌。IC50&TargetHumanEndogenousMetabolite体外研究ProtoporphyrinIXdisodium(3.6nmol/gtissue)tissuecancausenecrosisinnormalratcolonicmucosaonexposuretolight[4].ProtoporphyrinIXdisodium(6.6nmol/gtumor)delaystumorgrowthafterirradiationofatumorinrats[4].ProtoporphyrinIXdisodium(0-25μM,2h)rapidlyresultsinincreasednuclearG4levelsinHelacells[5]。体内研究ThehighestlevelofProtoporphyrinIXdisodium(approximately6.3nmol/gtissue)isfoundinratliverandintestine,followedbyaorta(4.3nmol/gtissue)andoesophagus(2.1nmol/gtissue),3hafterAminolevulinicacid(300mg/kg,i.v.,asingledose)administration[4].户使⽤本产品发表的科研⽂献•SciBull.2021May15;66(9):925-936.•NanoToday.2021,101212.•GenomeBiol.2022Dec15;23(1):259.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE•JControlRelease.2024Aug20:374:230-241.•JNanobiotechnology.2024Jun21;22(1):358.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].YasushiNakai,etal.ProtoporphyrinIXinducedby5-aminolevulinicacidinbladdercancercellsinvoidedurinecanbeextracorporeallyquantifiedusingaspectrophotometer.[2].MyrzakhmetovB,etal.PhotophysicalPropertiesofProtoporphyrinIX,Pyropheophorbide-aandPhotofrin®inDifferentConditions.Pharmaceuticals(Basel).2021Feb9;14(2):138.[3].TopeWD,etal.ProtoporphyrinIXfluorescenceinducedinbasalcellcarcinomabyoraldelta-aminolevulinicacid[J].PhotochemPhotobiol.1998Feb;67(2):249-55.[4].vandenBoogertJ,etal.5-Aminolaevulinicacid-inducedprotoporphyrinIXaccumulationintissues:pharmacokineticsafteroralorintravenousadministration[J].JPhotochemPhotobiolB.1998Jun15;44(1):29-38.[5].LiC,etal.G-quadruplexessensenaturalporphyrinmetabolitesforregulationofgenetranscriptionandchromatinlandscapes.GenomeBiol.2022Dec15;23(1):259.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplication