GM-60186-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGM-60186Cat.No.:HY-169229分⼦式:C₃₀H₃₃FN₂O₄分⼦量:504.59作⽤靶点:5-HTReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性GM-60186⼀种5-HT受体2B(HTR2B)抑制剂，IC50为257nM。GM-60186可显著抑制结直肠癌的增殖和迁移。IC50&Target5-HT2BReceptor257nM(IC50)体外研究GM-60186(50-500ꢀnM;72hours)effectivelyinhibitstheproliferationincolorectalcancer(CRC)cells[1].GM-60186(500ꢀnM;24-48hours)effectivelyinhibitscolorectalcancermigration[1].CellViabilityAssay[1]CellLine:COLO-205,MC38,CT26andCaco2cellsConcentration:0,50,100,and500ꢀnMIncubationTime:72hoursResult:DemonstratedeffectiveinhibitionofcellproliferationintheseCRCcelllines.CellMigrationAssay[1]CellLine:COLO-205,CT26andMC38cellsConcentration:500ꢀnMIncubationTime:24,and48ꢀh1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEResult:Inhibitedcolorectalcancermigration.体内研究GM-60186(10-20mg/kg;IP;daily;for20days)significantlyreducestumorsizeandweightinxenograftmousemodels[1].AnimalModel:HomozygousmaleBALB/cnudemice(CAnN.Cg-Foxn1nu/Crl;8-week-old)injectedwithCOLO-205cells[1]Dosage:10mg/kg;20mg/kgAdministration:IP;daily;for20daysResult:Significantlyreducedtumorsizeandweight.REFERENCES[1].Jeong-YunLee,etal.InhibitionofHTR2B-mediatedserotoninsignalingincolorectalcancersuppressestumorgrowththroughERKsignaling.BiomedPharmacother.2024Oct:179:117428.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58