1-Methyladenosine-d3-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE1-Methyladenosine-d3hydrochlorideCat.No.:HY-113081AS分子式:C₁₁H₁₃D₃ClN₅O₄分子量:320.75作用靶点:Isotope-LabeledCompounds;EndogenousMetabolite;PPAR;Hedgehog作用通路:Others;MetabolicEnzyme/Protease;CellCycle/DNADamage;VitaminDRelated/NuclearReceptor;StemCell/Wnt储存方式: -20°C,sealedstorage,awayfrommoistureandlightInsolvent:-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)溶解性数据体外实验DMSO:50mg/mL(155.88mM;Needultrasonicandwarming)SolventMass1mg5mg10mgConcentration制备储备液1mM3.1177mL15.5885mL31.1769mL5mM0.6235mL3.1177mL6.2354mL10mM0.3118mL1.5588mL3.1177mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存方式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。BIOLOGICALACTIVITY生物活性1-Methyladenosine-d3hydrochloride是氘标记的1-Methyladenosine(HY-113081)的盐酸盐形式。1-Methyladenosine是一种RNA修饰，可作为肿瘤标志物，其体内水平升高与癌症发生有关。1-Methyladenosine甲基化后可通过上调PPARδ表达，调节胆固醇代谢并激活Hedgehog信号通路，来驱动肝脏肿瘤的发生。REFERENCES1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemERussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.HauenschildR,etal.ThereversetranscriptionsignatureofN-1-methyladenosineinRNA-Seqissequencedependent.NucleicAcidsRes.2015Nov16;43(20):9950-64.BanysK,etal.EffectofGenisteinSupplementationontheProgressionofNeoplasmsandtheLeveloftheModifiedNucleosidesinRatsWithMammaryCancer.InVivo.2021Jul-Aug;35(4):2059-2072.WangY,etal.N1-methyladenosinemethylationintRNAdriveslivertumourigenesisbyregulatingcholesterolmetabolism[J].Naturecommunications,2021,12(1):6314.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3