Xanthotoxol-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEXanthotoxol(Standard)Cat.No.:HY-30152RCASNo.:2009-24-7分⼦式:C₁₁H₆O₄分⼦量:202.16作⽤靶点:5-HTReceptor;ReactiveOxygenSpecies;EndogenousMetabolite作⽤通路:GPCR/GProtein;NeuronalSignaling;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Xanthotoxol(Standard)Xanthotoxol的分析标准品。本产品⽤于研究及分析应⽤。Xanthotoxol(8-Hydroxypsoralen)⼀种线性呋喃⾹⾖素，补⾻脂素衍⽣物和CYP450抑制剂。Xanthotoxol具有抗炎，抗氧化，5-HT拮抗和神经保护作⽤。Xanthotoxol抑制CYP3A4和CYP1A2的IC50s分别为7.43μM和27.82μM。Xanthotoxol可通过MAPK和NF-κB途径抑制炎症。IC50&Target5-HT[1]REFERENCES[1].MaZ,etal.MetabolismandMetabolicInhibitionofXanthotoxolinHumanLiverMicrosomes.EvidBasedComplementAlternatMed.2016;2016:5416509.[2].MaZ,etal.MetabolismandMetabolicInhibitionofXanthotoxolinHumanLiverMicrosomes.EvidBasedComplementAlternatMed.2016;2016:5416509.[3].HeW,etal.Xanthotoxolexertsneuroprotectiveeffectsviasuppressionoftheinflammatoryresponseinaratmodeloffocalcerebralischemia.CellMolNeurobiol.2013Jul;33(5):715-22.[4].LeeY,etal.Anti-InflammatoryEffectsofPsoralenDerivativesonRAW264.7CellsviaRegulationoftheNF-κBandMAPKSignalingPathways.IntJMolSci.2022May22;23(10):5813.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: