Vortioxetine-d6-Lu-AA-21004-d-sub-6-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEVortioxetine-d6Cat.No.:HY-15414S1CASNo.:1629684-23-6Synonyms:LuAA21004-d6分⼦式:C₁₈H₁₆D₆N₂S分⼦量:304.48作⽤靶点:SerotoninTransporter;5-HTReceptor;Isotope-LabeledCompounds作⽤通路:NeuronalSignaling;GPCR/GProtein;Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Vortioxetine-d6(LuAA21004-d6)氚代标记的Vortioxetine(HY-15414)。Vortioxetine(LuAA21004)5-HT3A，5-HT7受体的拮抗剂(Ki:3.7nM，19nM)和5-羟⾊胺转运体(SERT)的抑制剂(Ki:1.6nM)，还5-HT1A的激动剂和5-HT1B的部分激动剂(Ki:15nM，33nM)。REFERENCES[1].Bang-AndersenB,etal.Discoveryof1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine(LuAA21004):anovelmultimodalcompoundforthetreatmentofmajordepressivedisorder.JMedChem.2011May12;54(9):3206-21.[2].GuillouxJP,etal.Antidepressantandanxiolyticpotentialofthemultimodalantidepressantvortioxetine(LuAA21004)assessedbybehaviouralandneurogenesisoutcomesinmice.Neuropharmacology.2013May28;73C:147-159.[3].TheunissenEL,etal.Arandomizedtrialontheacuteandsteady-stateeffectsofanewantidepressant,vortioxetine(LuAA21004),onactualdrivingandcognition.ClinPharmacolTher.2013Jun;93(6):493-501.[4].RothschildAJ,etal.Vortioxetine(LuAA21004)5mgingeneralizedanxietydisorder:resultsofan8-weekrandomized,double-blind,placebo-controlledclinicaltrialintheUnitedStates.EurNeuropsychopharmacol.2012Dec;22(12):858-66.[5].MrkA,etal.PharmacologicaleffectsofLuAA21004:anovelmultimodalcompoundforthetreatmentofmajordepressivedisorder.JPharmacolExpTher.2012Mar;340(3):666-75.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0