急性乙二醇中毒诊治研究现状

剂量约1～2ml/kg,或约1500mg/kg[4]。EG中毒患者临床症状分为三个阶段[11]:第一阶段：摄入EG30min至12h情况下，应该怀疑存在有毒醇(甲醇、乙二醇、异丙醇)中毒。而无0G增高并和100%,特异性分别为94.4%和88.5%),并且确定了乙醇酸与AG明显相关(r延长，EG逐渐代谢转化为有机酸(乙醇酸、乙醛酸、草酸),由于代谢的速率酶法检测的乳酸值与乳酸脱氢酶法检测的乳酸值之间的差值被称为“乳酸间EG浓度>20mg/dl或有摄入潜在有毒剂量的EG病史；hemodiafiltration,CVVHD)期间甲吡唑剂量建议与IHD(1mg/kg/h)比较，中毒(pH<7.25);(2)肾功能衰竭；(3)血EG浓度>50mg/dl。有文献指出，烈推荐血液透析；(2)使用乙醇治疗，且EG浓度>20mmol/L(124mg/dl),建ol/L(62mg/d1),强烈推荐血液透析治疗；(4)如果乙醇酸盐浓度>12mm或AG>27mmol/L,强烈推荐血液透析；(5)如果乙醇酸盐浓度为8～12mmol/L或AG为23～27mmol/L,建议行血液透析；(6)如果存在严重的临床特征(昏迷、癫痫发作或急性肾损伤),强烈推荐行血液透析；(7)首选IHD,次选CVEmergMedClinNorthAm,2022,40(2):327-341.DOI:10.1016/j.emc.2022.01.012.diagnosis,andmanagement[J].ClinJAmSocNephrol,2008,3(1)08-225.DOI:10.2215/CJN.03220807.3261-e3264.DOI:10.1093/milmed/usac380.nueddosingoffomepizolecity[J].ClinToxicol(Phila),2021,59(2):106-110.DOI:[5]Sommerfeld-KlattaK,PrzystanowicEffectofrepeatedadministrationof4-methylpyrazoleonrenalfunctionandlipidperoxidationproductsinratkidneyalpoisoning[J].EnvironToxicolPharmacol,2tion[J].Praxis(Bern1994),2018,107(20):1097-1106.DOI:10.1024/1661-8157/a003071.[7]JacobsenD,0vreialysis[J].ActaMedScand,1984,216(4):409-416.mofacuterenalfailureinethyleneglycolpoisoning?[J].Col(Phila),2009,47(9):859-869.DOI:10.3109/15563650903344793.[9]MoreauCL,KernsW2nd,TomaszewskiCA,etroup[J].JToxicolClinToxicol,199gement:anemergencymedicinereview[J(3):375-383.DOI:10.1007/s11739-018-1799-9.365-377.DOI:10.1016/j.cca.2011.10.034.[12]GallagherN,EdwardsFJ.ThediagnosilcoholpoisoningintheemergencyvJEmergMed,2019,3(3):e28.DOI:10.22114/ajem.v0i0.153.[13]RossJA,Borekn,2021,37(3):643-656.DOI:10.1016/j.ccc.2021.03.009.[14]MeyerH.Plasmaburn-mindthegap[J].PhilosTranngSci,2024,382(2280):20230406.DOI:10.1098/rsta.2023.0406.0.1093/ajcp/aqab189.029.[16]FenvesAZ,EmmettM.Approachtopatientswithhightabolicacidosis:corecurriculum2021[J].AmJKidne(4):590-600.DOI:10.1053/j.ajkd.2021.02.341.[17]PorterWH,RutterPtheroleofserumglycolicacidinhemodialysisxicol,2001,39(6):607-615.DOI:10.1081/clt-100108493.poisonedpatient[J].EmergMedClinNorthAm,2022,40(2):251-264.DOI:10.1016/j.emc.2022.01.002.ersinethyleneglycol(7):798-807.DOI:10.1080/15563650.2022.2049811.18,54(6):815-818.DOI:10.1016/j.jemerm022,6(1):68-70.DOI:10.5811/cpcem.2021.12.54928.4(2):1-3.DOI:10.1159/000499967.lpoisoning[J].JAnalToxicol,2009,33/jat/33.3.174.leneglycoltoxicitymimickingmyocardialinfarction[J].Jdiol,2020,58:128-131.DOI:10.1016/j.jelectrocard.2019.12.003.[25]CorrP,SzólicsM.NeuDOI:10.1111/j.1754-9485.2012.02remetabolicacidosis"[J].AfrJEmergMed,2021,11(2):263.DOI:[27]McMartinK,JacobsenD,HovdaKE.Anti(3):505-515.DOI:10.1111/bcp.12824.0I:10.1136/archdischild-2020-nppg.2.[29]WallemacqPE,VanbinstR,HaufroidV,etaeterminationof4-methylpyrazoleforpharmacokineticugMonit,2004,26(3):258-262.DOI:10.1097/00007691-200406000-00[30]RasamisonR,BessonH,BerleurMP,etClinToxicol(Phila),2020,58(7):742-747.DOI:10.1080/1556365/s40199-021-00418-4.colpoisoningwithalcohoracorporealtreatments:asystematicreview[J].ClinToxicol(Phila),2022,60(7):784-797.DOI:10.1080/15563650.2022.2049810.[33]VelezLI,ShepherdG,LeeYC,etal.Et[34]DetailleT,WalreMed,2004,5(5):490-491.DOI:10.1097/01.PCC.0000128600.17670.[35]BuchananJA,AlhelailM,CetarukEW,etaon[J].JMedToxicol,2010,6(2):131-134.DOI:10.1007/s131[36]MégarbaneB.Treatmentofpatientswithethyleneglycolormethanolpoisoning:focusonfomepizole[J].OpenAccess67-75.DOI:10.2147/0AEM.S5346.[37]BrentJ,McMartinK,PhillipsS,etmentofethyleneglycolpoisoning.Methylpyrazolefortoxicalstudygroup[J].NEnglJSeminDial,2011,24(4):441-442.DOI:10.1111/j.1525-139X.2011.0[39]LaoYE,VartdalT,Toxicol(Phila),2022,60(4):451-457.DOI:10.1080/15563650.[40]KrautJA,MullinsME.ToxicAlcohols[J].8(3):270-280.DOI:10.1056/NEJMra1615295.0/15563650.2020.1865542.[42]Judea-PustaCT,Mu?iuG,Pa?cal?uAV,etal.Thehyleneglycol.Casereport[J].RomJMorpholethyleneglycol