Pentoxifylline-Standard-BL-191-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPentoxifylline(Standard)Cat.No.:HY-B0715RCASNo.:6493-05-6Synonyms:BL-191(Standard);PTX(Standard);Oxpentifylline(Standard)分⼦式:C₁₃H₁₈N₄O₃分⼦量:278.31作⽤靶点:HIV;Phosphodiesterase(PDE);Autophagy作⽤通路:Anti-infection;MetabolicEnzyme/Protease;Autophagy储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Pentoxifylline(Standard)Pentoxifylline的分析标准品。本产品⽤于研究及分析应⽤。Pentoxifylline(BL-191)⼀种⾎液流变学改剂。Pentoxifylline⼀种具有⼝服活性的，⾮选择性的磷酸⼆酯酶(PDE)抑制剂，具有免疫调节、抗炎、⾎液流变学改、抗纤溶和抗增殖作⽤。Pentoxifylline可⽤于研究周⾎管疾病、脑⾎管疾病和其他⼀些涉及局部微循环缺陷的疾病[1][2][3]。IC50&TargetPDE[1]体外研究Pentoxifylline(0.1-50mM;24-48hours)inhibitscellproliferationinadose-dependentmanner[3].Pentoxifylline(0.5mM;12-36hours)increasesapoptosisanddecreasesautophagylevelsinMDA-MB-231cells[3].Pentoxifylline(0.5mM;12-36hours)inducesautophagyinMDA-MB-231cells[3].Pentoxifylline(0.5mM;24-48hours)blockscellcycleattheG0/G1phase[3].PentoxifyllineresultsinhighLC3-II/LC3-ratio[3].体内研究Pentoxifylline(200mg/kg;i.p.)hasaprotectiveeffectonratswithtransientglobalischemiaandreducescognitiveimpairment[4].•MolCancer.2022Apr27;21(1):106.•JIntegrAgric.2023Feb24.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE•EurJPharmacol.2023Feb21;175607.•OncolRep.2021Jan22.•JCancerResClinOncol.2023Mar31.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].IffatHassan,etal.Pentoxifyllineanditsapplicationsindermatology.IndianDermatolOnlineJ.2014Oct-Dec;5(4):510–516.[2].AWard,etal.Pentoxifylline.Areviewofitspharmacodynamicandpharmacokineticproperties,anditstherapeuticefficacy.Drugs.1987Jul;34(1):50-97.[3].YessicaCristinaCastellanos-Esparza,etal.Synergisticpromotingeffectsofpentoxifyllineandsimvastatinontheapoptosisoftriple-negativeMDA-MB-231breastcancercells.IntJOncol.2018Apr;52(4):1246-1254.[4].ShabnamMovassaghi,etal.EffectofPentoxifyllineonIschemia-inducedBrainDamageandSpatialMemoryImpairmentinRat.IranJBasicMedSci.2012Sep-Oct;15(5):1083-1090.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuse