Noscapine-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENoscapine(Standard)Cat.No.:HY-13716RCASNo.:128-62-1分⼦式:C₂₂H₂₃NO₇分⼦量:413.42作⽤靶点:OpioidReceptor;Apoptosis作⽤通路:GPCR/GProtein;NeuronalSignaling;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Noscapine(Standard)Noscapine的分析标准品。本产品⽤于研究及分析应⽤。Noscapine((S,R)-Noscapine)⼀种具有⼝服活性的苯酞异喹啉⽣物碱，具有强效镇咳作⽤。Noscapine通过激活sigma阿⽚类受体(sigmaopioidreceptors)发挥镇咳作⽤，⼀种⾮竞争性Bradykinin抑制剂。Noscapine破坏微管动⼒学，诱导细胞有丝分裂停滞和凋亡(apoptosis)以及活性。Noscapine具有抗癌，神经保护，抗炎活性，并且可以穿越⾎脑屏障。IC50&TargetSigmaopioidreceptors[4]Bradykinin[5]Apoptosis[1]REFERENCES[1].JarenWLanden,etal.NoscapineCrossestheBlood-BrainBarrierandInhibitsGlioblastomaGrowth.ClinCancerRes.2004Aug1;10(15):5187-201.[2].YunfanYang,etal.CYLDRegulatesNoscapineActivityinAcuteLymphoblasticLeukemiaviaaMicrotubule-DependentMechanism.Theranostics.2015Mar2;5(7):656-66.[3].VartikaTomar,etal.NoscapineandItsAnalogsasChemotherapeuticAgent:CurrentUpdates.CurrTopMedChem.2017;17(2):174-188.[4].BiancaLokhorst,etal.InteractionofOTCDrugNoscapineandAcenocoumarolandPhenprocoumon.BrJClinPharmacol.2019May;85(5):1041-1043.[5].SAEbrahimi,etal.InteractionofNoscapineWiththeBradykininMediationoftheCoughResponse.ActaPhysiolHung.2003;90(2):147-55.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792