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Chapter12ReproductionDongJing(董静)
Dept.Physiology
QingdaoUniversityEmail:.cnMaleReproductionSpermatogenesis:formationofspermEndocrinefunctionsoftestisRegulationoftestisfunctionSection1
Testisendocrineandmalereproductivephysiology
一、Maleprimarysexorgan:Testis
SpermatogenesisofTestis(一)Theprocessofspermatogenesis(二)Thetransportofspermsandejaculation
MaleReproductiveAnatomyandPhysiologyTestisEpididymisVasdeferensSeminalvesicleProstateBulbourethralEjaculatoryductUrethraPenisMaleReproductiveAnatomyandPhysiologySertoliCellFunctionSertoliCellsNourishhealthycells&phagocytizedamagedgermcellsSynthesizeluminalproteinsMaintaintubularfluidConvertandrogenstoestrogensAresiteforhormonalmodulationoftubularfunctionMajorTesticularSteroids()=RelativeactivitywhereTactivity=100AndrogensareC19steroidsMajorityof5a-DHTisformedinperipheraltissuesMaleSexSteroidSynthesisCholesterolmaybefromplasmaordenovosynthesisTmaybeconvertedinperipheraltissuestoestradiol&androstenedioneAndrostenedioneisthemajorsourceofestradiolinmenDelta-5pathwayisthemajorrouteinmenTransportofSexSteroidsinMalesMajorSexSteroidBindingProteinsTestosterone-EstrogenBindingProteinOnehighaffinitybindingsite(T1/2=22seconds)Bindingaffinityorderforsexsteroids=DHT(100)>T(33)>E(25)AlbuminOnelowaffinitybindingsite(T1/2-=1second)CortisolBindingGlobulinNobindingtoDHT,TorE2.BindsProgesteroneNormalDistributioninBlood
TEBG(30%),Albumin(68%),Free(2%) Activefractionincludesfree+albumin-boundfraction
AndrogenActivityIncreasedSpermatogenesisIncreasedBoneGrowthIncreasedbonematrix,calciumdepositionandpromotesepiphysealclosureIncreasedNitrogenBalanceIncreasedmusclemass,larynxsizeIncreasedatheleticperformanceIncreasedbasalmetabolicrate,redbloodcelldensityoxygenutilizationAlteredSkinFunctionIncreasedthickness,melanindepositionsebaceousglandsecretionSpermatogenesis:
SpermProductionintheTestisSeminiferoustubulesSpermatidsSpermatocytesSpermatozoaSertolicellsInterstitialtissueLeydigcellsCapillariesSpermatogenesisSpermatozoaStructureandFunctionsinReviewFigure26-10:SpermstructureHeadAcrosome:Nucleus:MidpieceCentrioles:Mitochondria:Tail:flagellumMicrotubules:GnRH
LH
Leydigcells
testosterone
20sexcharact.GnRH
FSH
Sertolicells
spermatoctyematurationInhibinfeedback–FSH,testosterone–short&longloopsRegulationofSpermatogenesisTheregulationoftestesfunctionsFigure26-11:HormonalcontrolofspermatogenesisControloftestesfunctionsbyhypothalamusandpituitaryFeedbackregulationoftesteshormonesHypothalamic-PituitaryregulationofTesticularFunctionFemaleReproduction,PregnancySexualDifferentiation&GrowthFemaleReproductiveAnatomyandPhysiology:OverviewOvaryFallopiantubeFimbriaeUterusCervixEndometriumVaginaClitorisLabiaFemaleReproductiveAnatomyandPhysiology:OverviewFigure26-12b:ANATOMYSUMMARY:FemaleReproductionTwocell-twogonadotropinschemePhysiologicaleffectsofestrogenEstrogen-Uterus-Ovary-Vagina-Breast-MetabolismFollicularStructureOvary:DetailsofHistology&PhysiologyFigure26-12d:ANATOMYSUMMARY:FemaleReproductionMenstrualCycle:EggMaturation,andEndometrialGrowthFollicularphaseEggmaturesOvulationEggreleasedLutealphaseCorpusluteumEndometriumPrepforblastocystNoPregnancyMensesFollicularGrowthRegulationGnRHrisesinresponsetoadeclineininhibinandsexsteroidsGnRHstimulatesriseinpituitaryFSH&LHsecretion.FSHstimulatesnewfolliclegrowthLHinducesthecalcellgrowth,vascularization&androgensynthesisFSHstimulatesgranulosacellproductionofE2&LHreceptorFollicularGrowthRegulation2LHactonthecal&granulosacellsandFSHactsongranulosacellsLatefollicularphasehaselevatedfollicularfluidE2,P,FSHandLHbutlowandrogensFollicularphaseOvulationLutealphaseovariancycleFSHstimulatesfolliculardevelopmentEstrogen:+feedback,limitsmorefolliclesEndocrineControlofMenstrualCycle:
FollicularPhase
Estrogen
LH"surge"&FSHspike
eggreleaseInhibin
pushesFSHdown,
newfollicledevelopmentEndocrineControlofMenstrualCycle:OvulationOvulationThestigmata,acone-shapedprotrusionofthefolliclewall,appearsjustbeforeovulationPreovulatoryfollicularfluidhaselevatedE2,P,FSH,LH,oxytocin,plasminactivity&collaginaseactivityExtensivefollicularvascularizationoccursimmediatelypriortoovulationFigure26-14a,b:HormonalcontrolofthemenstrualcycleEndocrineControlofMenstrualCycle:
FollicularPhaseandOvulationGranulosacellsformcorpusluteum
progesterone
progesterone&estrogenmaintainendometriumInhibincontinuestolimitnewfolliculardevelopmentEndocrineControlofMenstrualCycle:LutealphasePregnancy:maintain
progesterone,estrogen&inhibinNopregnancy:
progesterone,estrogen&inhibinMenses,
FSH&LH
newfollicledevelopmentEndocrineControlofMenstrualCycle:
LateLutealphaseEndocrineControlofMenstrualCycle:
LutealphaseandLateLutealphaseFigure26-14c,d:HormonalcontrolofthemenstrualcycleOverviewoftheMenstrualCyclePlacentaandFurtherEmbryonicDevelopmentFigure26-19a,b:TheplacentaBirth:ParturitionLabor (initiatedbyafetalsignalRhythmic (stretchinducesreleaseofoxytocin)Uterine (oxytocincontinuesuterinecontractionsContractionsCervicaldilation (inducedbyrelaxin)Delivery BabyPlacentaBirth:ParturitionFigure26-20:Parturition:thebirthprocessRegulatorsofParturitionFigure26-21:ThepositivefeedbackloopofparturitionLaboronsetStretchstimulusOxytocinProstaglandinsPositivefeedback
Stretch
OxytocinBirthendsStimulusLactation:ProducingandReleasingMilkEstrogen&progesteronePrepsmammarytissuesProlactininhibitingH:Prolactin
milkproduction(otherrolesinfertility)Suckingstimulus
Oxytocin
"Milklet-down"reflexLactation:ProducingandReleasingMilkFigure26-23:ThehormonalcontrolofmilksecretionandreleaseReproductiveMaturation:PubertyIncreaseproductionofsexhormonesMaturationofreproductiveorgans&gameteproduction20sexualcharacteristicsMales:pubichair,beard,deepvoice,"wedge"bodyform&
musclemassFemales:menarche,pubichair,breasts&"pearshape"bodyformLaterinLifeMenopause:Female"Change-ofLife"Ovaries
respondingtoGnRH
Levelsofestrogen&progesteroneproducedCeaseeggdevelopment"Hotflashes",
osteoporosisrisk(hormonereplacementdebate)"Andropause"(?):Malechangesaregradual
Sexhormones:
musclemass,
libido,
erectionsViagra:PNS
NO
cGMP
degradationChapter12ReviewquestionMenstrualcycle:Puberty:Duringthelatefollicularphase,plasmaestrogenincreasestoelicitasurgeofwhichkindofhormone,whichthencausesovulation.Thehighlevelsofprogesterone,inthepresenceofestrogen,inhibitthesecretionofGnRHandtherebythatofthegonadotropins,sothat
menstruationdonotoccur.Chapter4CardiovascularPhysiologyKeyTerms1)fastresponsecell,2)slowresponsecell,3).autorhythmiccell.(autorhythmicity)4).Diastolicdepolarization.5)pacemaker(dominant
,latent
,ectopic
),6)prematuresystole(extrasystole),7)compensatorypause,8)positive/negativechronotropicaction,9)atrioventriculardelay,10)positive/negativedromotropicaction,11)positive/negativeinotropicaction,12)cardiaccycle,13)systole/diastole,14)cardiacoutput.,15)Strokevolume;16)ejectionfraction,17)cardiacindex,18)enddiastolicvolume(EDV),19)Starling’slawoftheheart(heterometricautoregulation),20)homometricregulation;21)Meanarterialpressure;22)Centralvenouspressure,23)effectivefiltrationpressure,24)sympatheticvasoconstrictortone,25)rostralventrolateralmedulla(RVLM),26)baroreceptorreflex,27)rennin-angiotensinsystem(RAS),ReviewQuestions
1.Describetherelationshipbetweenflow,pressure,andresistanceinthevascularsystem.2.DescribetheStarlingforcesthatdeterminethenetmovementoffluidacrossthecapillarywall.Defineflow-limitedexchangeanddiffusion-limitedexchange,anddescribethevariationsincapillarypermeabilityandstructureseenindifferentpartsofthebody.3.StatethePoiseuille–Hagenformulaforflowinbloodvessels,andexplainonthebasisofthisformulawhytheradiusofavesselissuchanimportantdeterminantofflow.4.WhatisaWindkessel?WhyaretheaortaandlargearteriescalledWindkesselvessels?WhatisthephysiologicsignificanceoftheWindkesseleffect?ReviewQuestions
5.Ayoungmanhasabloodpressureof130/73mmHg.Whatishispulsepressure?Whatishismeanarterialpressure?Howdidyoucalculateeachofthesepressures?6.Ittakesseveralmonthsfornervestogrowintotransplantedhearts.However,beforethenervesregrowinpatientswithtransplantedhearts,exerciseincreasestheircardiacoutput.Whatisthemechanisminvolved,andhowdoesitoperate?7.Whatistheejectionfraction?Whichconditionscauseittoincrease,andwhichconditionscauseittodecrease?Why?ReviewQuestions8.Nametheprincipalhormonesthataffectarterialbloodpressureandthephysiologicroleofeach.9.Outlinetheneuralmechanismsthatcontrolarterialbloodpressureandheartrate,includingthereceptors,afferentandefferentpathways,centralintegratingpathways,andeffectormechanismsinvolved.10.
Whydoesincreasedsympatheticactivitycauseanincreaseinrightatrialpressure?Whatarethemechanismsandpathwaysinvolved?11.
Whichhormonesaffecttheheartrateandhowdotheyproducetheireffects?Chaper9SensoryPhysiology
KeyTermsreceptorpotential,2)adequatestimulus,3
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