Diclofenac-diethylamine-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEDiclofenacdiethylamine(Standard)Cat.No.:HY-15036ARCASNo.:78213-16-8分子式:C₁₈H₂₂Cl₂N₂O₂分子量:369.29作用靶点:COX;Apoptosis作用通路:Immunology/Inflammation;Apoptosis储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Diclofenac(diethylamine)(Standard)是Diclofenac(diethylamine)的分析标准品。本产品用于研究及分析应用。Diclofenacdiethylamine是一种有效的，非选择性抗炎剂，为COX的抑制剂，在CHO细胞中，对人COX-1和COX-2的IC50值分别为4和1.3nM[1]。Diclofenacdiethylamine对绵羊COX-1和COX-2的IC50值分别为5.1μM，0.84μM[2]。Diclofenacdiethylamine通过活化caspase级联反应来诱导神经干细胞凋亡(apoptosis)[3]。IC50&TargetIC50:4nM(HumanCOX-1,inCHOcells),1.3nM(HumanCOX-2,inCHOcells)[1],5.1μM(OvineCOX-1),0.84μM(OvineCOX-2)[2]REFERENCESRiendeauD,etal.BiochemicalandpharmacologicalprofileofatetrasubstitutedfuranoneasahighlyselectiveCOX-2inhibitor.BrJPharmacol.1997May;121(1):105-17.LabibMB,etal.Design,synthesisofnovelisoindolinehybridsasCOX-2inhibitors:Anti-inflammatory,analgesicactivitiesanddockingstudy.BioorgChem.2018Oct;80:70-80.ChihoKudo,etal.DiclofenacInhibitsProliferationandDifferentiationofNeuralStemCells.BiochemPharmacol.2003Jul15;66(2):289-95.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021