Anti-inflammatory-agent-89-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAnti-inflammatoryagent89Cat.No.:HY-161815分⼦式:C₃₁H₃₉NO₇S分⼦量:569.71作⽤靶点:Others作⽤通路:Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Anti-inflammatoryagent89(5c)抑制所有哮喘特征。Anti-inflammatoryagent89通过其⽪质类醇和H2S释放成分对肺部结构的恢复和肺部炎症的减轻均有显著作⽤，有望⽤于哮喘的研究[1]。体外研究Anti-inflammatoryagent89(100μM,24h)showsnoreductionincellviabilityinRBL-2H3cells[1].CellCytotoxicityAssay[1]CellLine:RBL-2H3cellsConcentration:100μMIncubationTime:24hResult:DidnotshowanyreductionincellviabilitycomparedtothevehicleinRBL-2H3cells.体内研究Anti-inflammatoryagent89(1-2mg/kg,i.p.,administrated30minbeforeovalbuminsensitizationondays0and7for21days)inhibitsasthmalikefeaturesbyactingonpulmonaryinflammationinOvalbumin(OVA)(HY-W250978)sensitizedmice[1].AnimalModel:FemaleBALB/cmice(20g,8weeks)ofOVAsensitization[2]Dosage:1-2mg/kgAdministration:i.p.,administrated30minbeforeovalbuminsensitizationondays0and7for21days1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEResult:Inhibitedbronchialhyperreactivityinadose-dependentmannerandreducedpulmonaryIL-13levelsthatwellcorrelatewithbronchialreactivityinOVA(HY-W250978)sensitizedmice.ReducedOVA-inducedα-SMAover-expressionandrestoredthestructureofthealveolarsepta,bronchialepitheliumandairwaysmoothmuscleinOVA(HY-W250978)sensitizedmice.REFERENCES[1].ScognamiglioA,etal.Isothiocyanate-CorticosteroidConjugatesagainstasthma:Unitymakesstrength[J].EurJMedChem.2024Sep5;275:116636.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0