13-S-HPODE-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE13(S)-HPODECat.No.:HY-110406CASNo.:33964-75-9分⼦式:C₁₈H₃₂O₄分⼦量:312.44作⽤靶点:EGFR;EndogenousMetabolite作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性13(S)-HPODE在⼀些植物和哺乳动物中发现的亚油酸代谢物。体外研究13(S)-HPODEcanbeproducedbytheoxidationoflinoleicacidbylipoxygenase-1inmanyplants[1].Thedioxygenationcatalyzedbya15-lipoxygenaseandareductionofintermediate13-HPODEbyaglutathione-dependentperoxidasecanform13(S)-HODE[2].13(S)-HPODEcanstimulateEGF-dependentmitogenesisandup-regulationofEGF-dependenttyrosinephosphorylationbyinhibitingthedephosphorylationoftheEGFR[3].REFERENCES[1].GardnerHW,etal.Soybeanlipoxygenase-1enzymicallyformsboth(9S)-and(13S)-hydroperoxidesfromlinoleicacidbyapH-dependentmechanism.BiochimBiophysActa.1989Feb20;1001(3):274-81.[2].ReinaudO,etal.Oxidativemetabolismoflinoleicacidbyhumanleukocytes.BiochemBiophysResCommun.1989Jun15;161(2):883-91.[3].GlasgowWC,etal.Thelinoleicacidmetabolite,(13S)-hydroperoxyoctadecadienoicacid,augmentstheepidermalgrowthfactorreceptorsignalingpathwaybyattenuationofreceptordephosphorylation.DifferentialresponseinSyrianhamsterembryotumorsuppressorphenotypes.JBiolChem.1997Aug1;272(31):19269-76.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>