阿尔茨海默症英语介绍

Alzheimer’sDisease阿尔茨海默症

RonaldWilsonReagan罗纳德·威尔逊·里根第40任（第49-50届）美国总统president“IknowI'monmywaytothetwilight.Iknowthere'salwaysabrightdawnaheadoftheUnitedstates.Thankyou,myfriends.MayGodblessyouforever.”briefintroduction01Pathogeny＆Treatment03Clinicalmanifestation02Other04Catalog

briefintroduction

1What?Alzheimer'sdisease(AD)isaprogressiveneurodegenerativedisorder.临床症状Clinicalsymptom记忆障碍dysmnesia失语aphasia失认agnosia执行功能障碍executivedysfunction痴呆dementiaThediseaseusuallybeginsafterage60,andriskgoesupwithage.TwotypesAlzheimer'sdisease(AD)

<65yearsoldseniledementia(SDAT)≥65yearsoldNameIn1906,ADisnamedbyDr.AloisAlzheimer,aGermandoctor.Dr.Alzheimernoticedchangesinthebraintissueofawomanwhohaddiedofanunusualmentalillness.Hefoundabnormalclumps.ScientistsalsohavefoundotherbrainchangesinpeoplewithAD.Nervecellsdieinareasofthebrainthatarevitaltomemoryandothermentalabilities.

Clinicalmanifestation

2Clinicalmanifestation

Ⅰ期Ⅱ期Ⅲ期death1-3

years2-10

years8-12yearsMilddementiaModeratedementiaSeveredementiaMorewomenthanmen7:5~4:6Diseaseforupto10-20years

DegradationofmemoryandcognitionWilliamUtermohlen的自画像Degradationofmemoryandcognition

WilliamUtermohlenisanAmericanartist,in1995hewasdiagnosedwithAlzheimer'sdisease.Sincethen,hehasdecidedtotakeadvantageofthelimitedtimeavailabletoretainmemoryandbetterunderstandhimselfthroughselfportraits.Williaminsistedthe5NewYearpaintingsselfportrait,untilcompletelyforgottenhowtodraw.Fromtheuseofskilleddrawing,darkportrayalofvividfeatures,tothesamecolor,shapedeformation,selfportraitbecamemoreandmoreabstract(picturedabove).Degradationofmemoryandcognition

"theeffectsofAlzheimer'sdiseaseontherightparietallobeofthebrainareparticularlysevere,whichdirectlyaffectstheabilityofthebraintovisualizeanddeveloptheabilitytodrawpicturesofthebrain."saidDr.BruceMiller,aneurologist.Hisworkbecamemoreabstract,maybetheparietalfunctiondamaged,causingblindness.Whatkindofchangeshaveoccurredinthebrainsofpatientswithdementia,whichisnotyetfullyunderstoodbytheworld'sacademia.

Pathogeny＆Treatment

3PathogenesishypothesisofADPathogenyAbnormalamyloidbetacelldepositioninneuronsAbnormalphosphorylationoftauproteinvsBetaamyloid(bluecurve)andTauprotein(orangecurve)Researchpaperspublishedinrecent30yearsTreatmentincreasetheconcentrationofacetylcholine(Ach)inthebrainpromotingsurvivalofcholinergicneuronsinthebrainorimprovingtheirnerveconductionfunctionreducingtheproductionorpromotingdegradationofbetaamyloidOther4StillAliceFilmThefilmtellsthestor