Flobufen-VUFB-16066-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEFlobufenCat.No.:HY-106835CASNo.:112344-52-2Synonyms:VUFB16066分⼦式:C₁₇H₁₄F₂O₃分⼦量:304.29作⽤靶点:COX;Lipoxygenase作⽤通路:Immunology/Inflammation;MetabolicEnzyme/Protease储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:40mg/mL(131.45mM;ultrasonicandadjustpHto9with1MNaOH)MassSolvent1mg5mg10mgConcentration制备储备液1mM3.2863mL16.4317mL32.8634mL5mM0.6573mL3.2863mL6.5727mL10mM0.3286mL1.6432mL3.2863mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Flobufen(VUFB16066)⼀种⾮甾体抗炎剂，还环氧合酶(COX)和5-脂氧合酶(5-LOX)抑制剂。Flobufen可抑制同种抗原驱动的细胞免疫反应和刺激腹膜细胞的吞噬作⽤。Flobufen可改免疫病理紊乱，对类风湿性关节炎有抑制作⽤。1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEIC50&TargetCOX;5-LOX[1]REFERENCES[1].KvasnickováE,etal.Metabolicpathwaysofflobufen-anewantirheumaticandantiarthriticdrug.Interspeciescomparison.ExpToxicolPathol.1999Jul;51(4-5):352-6.[2].DrsataJ,etal.Inhibicedekarboxylázyaromatickýchaminokyselinprotizánĕtlivýmilátkamiflobufenemakyselinou2',4'-difluorbifenyl-4-yloctovou[Inhibitionofaromaticaminoaciddecarboxylasesbytheanti-inflammatoryagentflobufenand2',4'-difluorbiphenyl-4-aceticacid].CeskFarm.1989Nov;38(9):407-10.[3].PanajotovaV,etal.Pharmacologicalprofileofthenovelpotentantirheumatic4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoicacid.Arzneimittelforschung.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58