Parecoxib-Sodium-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEParecoxibSodium(Standard)Cat.No.:HY-17474ARCASNo.:198470-85-8分⼦式:C₁₉H₁₇N₂NaO₄S分⼦量:392.4作⽤靶点:COX作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Parecoxib(Sodium)(Standard)Parecoxib(Sodium)的分析标准品。本产品⽤于研究及分析应⽤。ParecoxibSodium(SC69124A)⼀种选择性强、⼝服活性强的COX-2抑制剂，Valdecoxib(HY-15762)的前体。ParecoxibSodium⼀种⾮甾体抗炎试剂(NSAID)，可抑制前列腺素(PG)的合成。动物实验中，ParecoxibSodium可⽤于缓解术后急性疼痛和⾻关节炎、类风湿关节炎等慢性炎症症状。IC50&TargetIC50:COX-2[1]REFERENCES[1].JunTang,etal.Effectofparecoxib,anovelintravenouscyclooxygenasetype-2inhibitor,onthepostoperativeopioidrequirementandqualityofpaincontrol.Anesthesiology[2].JLMateos,etal.[Selectiveinhibitorsofcyclooxygenase-2(COX-2),celecoxibandparecoxib:asystematicreview].DrugsToday(Barc).2010Feb;46SupplA:1-25.[3].BoWang,etal.Chronicadministrationofparecoxibexertsanxiolytic-likeandmemoryenhancingeffectsandmodulatessynaptophysinexpressioninmice.BMCAnesthesiol.2017Nov13;17(1):152.[4].Lin-YongLi,etal.Parecoxibinhibitsglioblastomacellproliferation,migrationandinvasionbyupregulatingmiRNA-29c.BiolOpen.2017Mar15;6(3):311-316.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021