特色细胞因子-高质量细胞培养用细胞因子

高质量细胞培养用细胞因子高纯度低内毒素高活性完善的质量控制体系北京义翘神州科技股份有限公司01高质量细胞培养用细胞因子细胞的体外培养需要添加合适的细胞因子，以维持其正常的生长、增殖或者分化。高质量细胞因子在CAR-T/CAR-NK细胞治疗、类器官培养及干细胞治疗等热门领域显得尤为重要，直接关系到最终应用的成败。义翘神州针对不同细胞培养的实际需求，精心设计、研发和生产了一系列高纯度、高活性、高稳定性、低内毒素的特色细胞因子产品，特别适用于免疫细胞、干细胞、类器官等体外培养应用场景。另外，为满足新药研发的不同阶段的各个环节，我们提供GMP级、RUO级细胞因子，全面加速生物药的研发上市进程。纯度大于95%，经SDS

&

SEC-HPLC验证高活性，经ELISA、cell-based

assays验证

高批间一致性无标签或小标签表达资质证书2024年值得关注的生长因子供应商CNAS证书FDA

DMF备案ISO

9001:2015证书ISO

13485:2016证书GMP证书制剂不含载体蛋白低内毒素水平：<5‒10

EU/mg经过类器官、免疫细胞、干细胞等培养验证

ISO9001/ISO13485/GMP质量控制体系产品优势高质量细胞培养用细胞因子北京义翘神州科技股份有限公司高质量细胞培养用细胞因子02细胞因子功能介绍细胞因子生物学作用培养类型EGF调节和促进表皮细胞的生长与增殖促进角膜、皮肤等伤口修复干细胞：ESC/iPSC、NSC、MSC类器官：肠道、胃、脑、肝脏、肺、胰腺、前列腺、乳腺、内耳、血 管、甲状腺FGF2诱导内皮细胞生长和增殖促进血管新生维持多能干细胞的自我更新和未分化状态干细胞：ESC/iPSC、NSC、MSC免疫细胞：T细胞类器官：肠道、心脏、脑、肝脏、肺、肾脏、胰腺、前列腺、乳腺、内耳、血管FGF10促进上皮细胞的增殖和迁移调节肺、胃和皮肤等组织的发育和修复过程参与细胞分化、血管生成和神经细胞生长促进伤口愈合调节肢体和肺等多器官发育干细胞：ESC/iPSC、NSC

类器官：胃、心脏、肝脏、肺、胰腺、前列腺、乳腺、甲状腺VEGF165增强内皮细胞的增殖和存活促进血管生成增强血管通透性干细胞：ESC/iPSC、NSC、HSC免疫细胞：NK细胞、树突细胞、粒细胞类器官：血管Activin

A促进下丘脑、垂体和性腺激素的合成与分泌调节细胞增殖、分化、伤口修复以及组织和器官 形成干细胞：ESC/iPSC类器官：肠道、胃、心脏、肝脏、肺、前列腺GM-CSF促进粒细胞和巨噬细胞的生长和发育促进骨髓细胞的产生和分化参与伤口愈合干细胞：HSC免疫细胞：单核细胞/巨噬细胞、树突细胞、粒细胞FGF4调节胚胎发育、细胞增殖和细胞分化促进心肌血管生成，脊椎动物肢体发育促进再上皮化和伤口愈合与胃癌发展相关干细胞：ESC/iPSC、NSC、MSC类器官：肠道、胃、心脏、脑、肝脏、肾、甲状腺IFN-γ调节和增强机体的免疫反应抗病毒和抗肿瘤作用调控细胞生长和分化促进炎症反应干细胞：HSC免疫细胞：T细胞、NK细胞、单核细胞/巨噬细胞、树突细胞、

B细胞说明：

ESC/iPSC：胚胎干细胞/诱导性多能干细胞；NSC：神经干细胞；MSC：间充质干细胞；HSC：造血干细胞。北京义翘神州科技股份有限公司03高质量细胞培养用细胞因子Human

FGF-10

Protein,

HPLC-verified

(Cat#:

10573-HNAE)经肺、肾、胃、肝癌、肾癌、乳腺癌、胃癌等9种类器官培养验证人小肠类器官 人胃类器官产品验证数据Human

small

intestinal

organoids

werecultured

with

IL22

(Cat#:

13059-HNAE),FGF10

(Cat#:

10573-HNAE),EGF

(Cat#:

50482-MNCH),NOG

(Cat#:

50688-M02H).Data

provided

by

D1

Medical

Technology.Human

stomach

organoids

were

culturedwith

EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

gastric

cancer

organoids

werecultured

with

EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

R-Spondin

1/RSPO1

Protein,

HPLC-verified

(Cat#:

11083-HNAS)结直肠癌类器官LM-P2Day

7 Day

10 Day

14(B)不同形态的mCRC类器官培养过程；(C）原发肿瘤和患者衍生类器官的组织病理学特征。来源:/10.3389/fbioe.2023.1190637Day

1Day

3BFH&ETissue Organoid

OrganoidCRC-

PDO5CRC-

PDO30B

cOM-P6CRC-P10CRC-P14人胃癌类器官Human

FGF-10

Protein,

HPLC-verified

(Cat#:

10573-HNAE)人肺类器官 人肺癌类器官Human

lung

organoids

were

cultured

withFGF2

(Cat#:

10014-HNAE),FGF4(Cat#:

16043-HNAE),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

lung

cancer

organoids

werecultured

with

FGF2

(Cat#:

10014-HNAE),FGF4

(Cat#:

16043-HNAE),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

kidney

organoids

were

culturedwith

FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS),HGF

(Cat#:

10463-HNAS),FGF4

(Cat#:

16043-HNAE).Data

provided

by

D1

Medical

Technology.人肾类器官北京义翘神州科技股份有限公司高质量细胞培养用细胞因子04产品验证数据Human

EGF

Protein,

HPLC-verified

(Cat#:

10605-HNAE)Three

independent

batches

of

human

EGFprotein

(Cat#:

10605-HNAE)

have

i

dentical

bioactivity.160140120100806040200-20Proliferation,%1E-4

1E-3

0.01

0.1

1

10

100Human

EGF

(ng/mL)高批间一致性Batch

1Batch

2Batch

3iPSC-derived

human

vascular

organoids

werecultured

with

FGF2

(Cat#:

10014-HNAE),

VEGF165(Cat#:

11066-HNAH),

EGF

(Cat#:

10605-HNAE).Red

arrows

represent

vascular

organoids.Human

basic

FGF/FGF2

Protein

(Cat#:

10014-HNAE)人肝癌类器官 人胆管癌类器官Human

liver

cancer

organoids

werecultured

with

FGF2

(Cat#:

10014-HNAE),HGF

(Cat#:

10463-HNAS),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),TGFB1

(Cat#:

10804-HNAC),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

cholangiocarcinoma

organoidswere

cultured

withFGF2

(Cat#:

10014-HNAE),HGF

(Cat#:

10463-HNAS),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.Human

kidney

cancer

organoids

werecultured

with

FGF2

(Cat#:

10014-HNAE),FGF7

(Cat#:

10210-H07E),EGF

(Cat#:

50482-MNCH),FGF10

(Cat#:

10573-HNAE),NOG

(Cat#:

50688-M02H),RSPO1

(Cat#:

11083-HNAS).Data

provided

by

D1

Medical

Technology.人肾癌类器官高纯度HUVEC成管实验高纯度人血管类器官5

10

15

20

25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.mAU

400350300250200150100500kDa

M

11666.245.035.025.018.414.4Human/Cynomolgus

VEGF165

Protein

(Cat#:

11066-HNAH)Measured

in

a

cell

proliferation

assayusing

human

umbilical

vein

endothelialcells

(HUVEC).Induction

of

tube

formation

in

human

umbilicalvein

endothelial

cells

(HUVECs)

in

vitro.5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.mAU05101520kDa

M

11666.245.035.025.018.414.4Proliferation%0.01

0.1110

100VEGF165

Conc.

(ng/mL)活性验证义翘神州ED50=1.4

(ng/mL)10090

进口品牌ED50=4.0

(ng/mL)80706050403020100北京义翘神州科技股份有限公司05高质量细胞培养用细胞因子Human

IFN

gamma

Protein(Cat#:

11725-HNAE)Activin

A

Protein(Cat#:

10429-HNAH)Human

IL-2

Protein(Cat#:

11848-HNAE2)Human

Flt3

Ligand

Protein(Cat#:

10315-HNAE)Human

IL-21

Protein(Cat#:

10584-HNAE)Human

SCF

Protein(Cat#:

10451-HNAE)产品验证数据≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.Measured

in

anti-viral

assays

using

WISHcells

infected

with

vesicular

stomatitisvirus(VSV).Measured

by

its

ability

to

inhibit

proliferationof

MPC-11

cells.5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.Measured

in

a

cell

proliferation

assay

usingTF-1

human

erythroleukemic

cells.Measured

in

a

cell

proliferation

assay

usingCTLL2.5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.Measured

in

a

cell

proliferation

assay

usingM-NFS-60

mouse

myelogenous

leukemialymphoblast

cells.5

1015

20 25

minmAU

12010080604020011666.245.035.025.018.414.4kDa

M0.800.750.700.650.600.550.50ED50=8-80

pg/mL0.1

1

10

100Human

IFN

gamma

Conc.

(pg/mL)OD-Blank2040601008001E-41E-3

0.01

0.1

1 10

100

1000Activin

A

Conc.(ng/mL)Inhibition

%50ED

=0.5-5

ng/mLmAU

10080604020011666.245.035.025.018.414.4kDa

MmAU250200150100500kDa

M

11666.245.035.025.018.414.41E-5

1E-4

1E-3

0.01

0.1 1

10

100-500300025002000150010005000Proliferation

%Human

GM-CSF

Conc.

(ng/mL)Human

GM-CSF

Protein(Cat#:

10015-HNAH)3500

ED50=0.06-0.3ng/mL25002000150010005000-5000.1

1

10Human

IL-2

Conc.

(ng/mL)3000

ED50=1-8

ng/mLProliferation,%120010008006004002000-200-4001E-4

1E-3

0.01

0.1

1 10

100Human

IL-21

Conc.

(ng/mL)Measured

by

its

ability

to

induce

Interfer-on-gamma

secretion

by

human

naturalkiller

lymphoma

NK-92

cells.1400

ED

=0.4-2ng/mL50Proliferation,%0.01

0.1

1

10

100Human

Flt3

Ligand

Conc.

(ng/mL)Measured

in

a

cell

proliferation

assay

usingBaF3

mouse

proB

cells

transfected

withmouse

Flt3.5004003002001000Proliferation,%50ED

=1-6

ng/mL5

10

15

20 25

min≥

95%

as

determined

by

SDS-PAGE.≥

95%

as

determined

by

SEC-HPLC.Measured

in

a

cell

proliferation

assay

usingTF-1

human

erythroleukemic

cells.18.4mAU

kDa

M60

11666.250

45.040

35.030

25.020

14.41001E-3

0.01

0.1

1 10

100

1000Human

SCF

Conc.

(ng/mL)50040040030020020010000Proliferation,%ED50=1-8

ng/mL1400120010008006004002000-200Proliferation

%0.01

0.1

1

10 100

1000Human

M-CSF

Conc.

(ng/mL)Human

M-CSF

Protein(Cat#:

11792-HNAH1)1600

ED50=3-15

ng/mL北京义翘神州科技股份有限公司高质量细胞培养用细胞因子06细胞因子货号种属SEC-HPLC纯度内毒素宿主Activin

A10429-HNAHHuman,Mouse,

Rat,Cynomolgus,

Rhesus≥

95%<

10

EU/mgHEK293

CellsBMP-210426-HNAE1Human,Mouse,

Rat,Rhesus,

Canine≥

95%

(SDS)<

10

EU/mgE.

coliBMP410609-HNAE2Human≥

95%

(SDS)<

1.0

EU/µgE.coliDKK-110170-H08HHuman≥

95%<

10

EU/mgHEK293

CellsEGF10605-HNAEHuman≥

95%<

5

EU/mgE.

coliFGF210014-HNAEHuman≥

95%

(SDS)<

10

EU/mgE.

coliFGF-416043-HNAEHuman≥

95%<

10

EU/mgE.

coliFGF-910262-HNAEHuman≥

95%<

10

EU/mgE.

coliFGF-1010573-HNAEHuman≥

95%<

5

EU/mgE.

coliFGF-2110911-HNAEHuman≥

95%

(SDS)<

10

EU/mgE.

coliFlt3

Ligand10315-HNAEHuman≥

95%<

10

EU/mgE.

coliG-CSF10007-HNAHHuman≥

95%<

10

EU/mgHEK293

CellsGDNF10561-HNAEHuman≥

95%<

10

EU/mgE.

coliGM-CSF10015-HNAHHuman≥

95%<

10

EU/mgHEK293

CellsHGF10463-HNASHuman≥

95%<

10

EU/mgCHO

Stable

CellsIFN

gamma11725-HNAEHuman≥

95%<

5

EU/mgE.

coli11725-H08HHuman≥

95%<

1.0

EU/µgHEK293

CellsIL-1

beta10139-HNAEHuman≥

95%<

5

EU/mgE.

coliIL-211848-HNAE2Human≥

95%<

5

EU/mgE.

coliIL-311858-HNAEHuman≥

95%<

5

EU/mgE.

coliIL-411846-HNAEHuman≥

95%<

5

EU/mgE.

coliIL-610395-HNAEHuman≥

95%

(SDS)<

10

EU/mgE.

coliIL-711821-HNAEHuman≥

95%<

10

EU/mgE.

coliIL-1010947-HNAEHuman≥

90%<20

EU/mgE.

coliIL-12CT011-H08HHuman≥

95%<

5

EU/mgHEK293

CellsCT050-HNAHHuman≥

95%<

5

EU/mgHEK293

Cells高活性细胞因子产品列表GMP-grade

availableAnimal-free

available北京义翘神州科技股份有限公司07高质量细胞培养用细胞因子高活性细胞因子产品列表细胞因子货号种属SEC-HPLC纯度内毒素宿主IL-1510360-HNCEHuman≥

95%

(SDS)<20

EU/mgE.

coliIL-1810119-HNCEHuman>

95%<

10

EU/mgE.

coliIL-2110584-HNAEHum