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Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEAtreleuton-d4Cat.No.:HY-117853SCASNo.:2012598-86-4Synonyms:ABT-761-d4;VIA-2291-d4分⼦式:C₁₆H₁₁D₄FN₂O₂S分⼦量:322.39作⽤靶点:Lipoxygenase;Isotope-LabeledCompounds作⽤通路:MetabolicEnzyme/Protease;Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Atreleuton-d4(ABT-761-d4;VIA-2291-d4)氘代标记的Atreleuton(HY-117853)。体外研究Stableorradioisotope-labeledcompoundsallowprecisetrackingandquantificationofindividualatomsinmetabolicpathways.Stableisotopesgenerallydonotchangemolecularpropertiesbutmayslightlyaffectmetabolickinetics;radioactiveisotopesmayinterferewithcells.Markerscandistinguishendogenousandexogenousmetabolites,reducefalsepositives,andarebeneficialtoquantificationandreconstructionofmetabolicpathways[2].Incellcultureorenzymaticreactions,theuseofisotopemarkerscanpreciselycontroltheconcentrationandexposuretime,makingiteasytostudymetabolicreactionsandenzymeactivities.Throughstableisotopeanalyticalmetabolomics(SIRM),cellularmetabolicnetworkscanbestudied,keymetabolicnodesandregulatorymechanismscanbeidentified,andtargetscanbeprovidedforcompounddevelopment.Isotope-labeledcompoundscanbeusedincompetitionbindingexperimentstoevaluatetheaffinityandbindingkineticsofcompoundstoreceptorstohelpoptimizedesign.Stableisotopelabelsareusedasinternalstandardsinmassspectrometryanalysistoimproveanalysisaccuracyandreproducibilityandreducematrixeffectinterference[3].体内研究Isotopiclabelscannon-invasivelytrackthedistribution,transformationandclearanceofcompoundsandtheirmetabolitesinthebodythroughtechniquessuchasmassspectrometry(MS)andnuclearmagneticresonance(NMR),whichisbeneficialtothestudyofpharmacometabolickinetics(ADME).Isotopelabelingcanrevealspecificstepsinmetabolicpathways.Usingcompoundswithstableisotopelabelsatspecificlocationsdirectlyinhumansoranimalmodelscanalsohelpverifydrugmechanismsandevaluate1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEunexpectedsideeffects,improvingtheaccuracyandefficiencyofclinicalresearch[3].REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].SmithKA,etal.Soilandenvironmentalanalysis[M].MarcelDekkerIncorporated,2000.[3].FanTWM,etal.Stableisotope-resolvedmetabolomicsandapplicationsfordrugdevelopment[J].Pharmacology&therapeutics,2012,133(3):366-391.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalappli
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