DNMT-HDAC-IN-1-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDNMT/HDAC-IN-1Cat.No.:HY-158075CASNo.:2095619-17-1分⼦式:C₁₉H₁₆ClF₃N₂O₃分⼦量:412.79作⽤靶点:HDAC;DNAMethyltransferase作⽤通路:CellCycle/DNADamage;Epigenetics储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性DNMT/HDAC-IN-1(Compund15a)⼀种DNMT和HDAC双重抑制剂，对HDAC1和HDAC6的IC50值分别为56.84nM和17.39nM。DNMT/HDAC-IN-1可诱导细胞凋亡(Apoptosis)，⽤于肿瘤的研究。IC50&TargetHDAC1HDAC656.84nM(IC50)17.39nM(IC50)体外研究DNMT/HDAC-IN-1significantlysuppressK562andU937proliferationwithIC50valuesof2.85and1.06mM,respectively[1].WesternBlotAnalysis[1]CellLine:U937cellsConcentration:0,1,2.5,5μMIncubationTime:12hResult:inducedhistoneH3K9andhistoneH4K8acetylationandincreasedP16expression.ApoptosisAnalysis[1]CellLine:U937cellsConcentration:2.5,5,10μM1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEIncubationTime:36hResult:inducedapoptosisinU937cells.REFERENCES[1].YuanZ,etal.Design,synthesisandanticancerpotentialofNSC-319745hydroxamicacidderivativesasDNMTandHDACinhibitors.EurJMedChem.2017Jul7;134:281-292.[2].HuangW,etal.DualinhibitorsofDNMTandHDACinduceviralmimicrytoinduceantitumourimmunityinbreastcancer.CellDeathDiscov.2024Mar15;10(1):143.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: