蛋白质三级结构预测课件

蛋白质三级结构预测(Swissmodel)浆

Swissmodel基于同源建模的方法聚

是目前三级结构预测当中基于同源建模方法做的最好的一个之一优点是：如果能得到结果往往很可靠缺点是：很多时候得不到结果例：给定的example

进行三级结构预测主页SWISS-MODELTeamTorsten

Schwede:

ProjectLeaderFlorian

Kiefer:

SWISS-MODEL

Repository

Lorenza

Bordoli:Method

Development

anduser

supportKonstantin

Arnold:SWISS-MODELWorkspaceReferences:Whenyou

publishor

report

results

using

SWISS-●Arnold

K,Bordoli

L.,Kopp

J.,and

SchwedeT.(2006).The

SWISS-MODEL

Workspace:Aweb-based

environmentfor

proteinBioinformatics,22,195-201.·

KieferF,ArnoldK,künzliM,BordoliL,Schwede

T(2009).The

SWISS-MODEL·

Nucleic

Acids

Research.37,D387-D392.SWISS-MODEL

is

a

fully

automated

proteinWhat's

new?·

New

automated

modeling

pipeline

withassessmentscoresSWISS-MODELTemplate

IdentificationDomainAnnotationStructure

AssessmentTemplateLibrarystructure

homology-modeling

server,accessihleviathe

ExPASywebserver,orfromtheprogramDeepWiew

(Swiss

Pdb-Viewer).The

purpose

ofthis

server

is

to

make

Protein

Modellinge

o

ii

hemists

and

molecularecdodllrlaWtotsblissigsoeiolccbamWorkspaceAutomatedModeAlignmentMode

Project

ModeSWISS-MODELWorkspaceSwl5EMODFI

Rannsitnrvimproved

hierarchical

approach

for·

template

selection.Increased

sensitivity

of

template

detection(sequence

to

profle

search

using

an·

adapted

HHSearch

protocol)Search

by

SequenceSearch

by

ACMODEL,please

cite

the

relevant

publication

s:Peitsch,M.C.(1995)Protein

modeling

byNew

tools

for

model

and

structure

qualityToolsModellingRepository

and

associated

resources.Repositoryassessment:DfireandQmean

globalDocumentationE-mail

BioTechnology13:658-660.scores;Progres

residue

basedstructure

homology

modelling.Swiss

Institute

ofBioinformatics选用Automated

modeModelling[myWorkspace

]SwissModelAutomatic

Modelling

Mode②Email:ProjectTitle:BIOZ

NTTRmUM

SWISS-MODEL

WorkspaceProvide

a

protein

sequence

or

a

UniProt

AC

Code:Repository[login

]Submit

Modelling

RequestDacumentatianTaols输入序列、Email

、姓名、序列名字，然后提交等待结果，结果发到邮箱中YourRequest

hasbeen

Submitted:The

Request

has

been

submitted

to

the

queueing

system

and

will

run

soon.The

results

will

be

displayed

in

this

pageSWISS-MODEL

WorkspaceModelling

Tools

Repository[login

]BIOZENTRUm[myWorkspace

]StatusofyourRequest

is:submittedDocumentation三级结构可视化

(Pdbviewer)E

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