HER2-生物药物研发调研报告-1

HER2调研报告-12017/12/24HER2BackgroundHER2SignalingPathwayHER2Market蛋白开品开发战略产品推广方案ErbB2,alsocalledNeuandHer2(humanepidermalgrowthfactorreceptor2),isatypeImembraneglycoproteinthatisamemberoftheErbBfamilyoftyrosinekinasereceptors.ErbBfamilymembersserveasreceptorsfortheepidermalgrowthfactor(EGF)familyofgrowthfactors.ErbB2iswidelyexpressedinepithelialcellsandhasalsobeenfoundtobeover-expressedinalargenumberofbreastcarcinomas.AmongErbBfamilymembers,ErbB2isuniqueinthatithasnoidentifiedligands.Rather,ErbB2heterodimerizeswiththeothermembersoftheErbBfamily(ErbB1(EGFR),ErbB3,ErbB4)toformhigheraffinitysignalingcomplexes.BecauseErbB3containsadefectivekinasedomain,thekinasedomainofErbB2isresponsibleforinitiatingthetyrosinephosphorylationsignalthroughtheheterodimericreceptor.IthasbeenfoundthatadiscretethreeaminoacidsignalintheErbB3cytoplasmicdomainiscriticalfortransactivationofErbB2.Interestingly,thissamethreeaminoacidsignalhasalsobeenfoundinErbB1andErbB4.Phosphoinositide3-kinasehasbeenshowntoplayaroleinErbB2signaltransduction.ThecytoplasmicdomainofErbB2hasbeenshowntoassociatewithbeta-cateninandplakoglobin.HumanErbB2consistsof1255aminoacids(aa)witha21aasignalsequence,a631aaextracellulardomain,a23aatransmembraneregion,anda580aacytoplasmicdomain.ErbB2canbeshedfromthecellsurfacebyproteolyticcleavagebyanunidentifiedprotease.ErbB2appearstoplayrolesindevelopment,cancer,communicationattheneuromuscularjunctionandregulationofcellgrowthanddifferentiation(1-10).HER2BackgroundHER2SignalingPathwayEGFR/ErbB1ErbB2/Her2ErbB3/Her3ErbB4/Her4FGFR1FGFR1-4FGFR1alphaFGFR1betaFGFR2FGFR2alphaFGFR2betaFGFR3FGFR4HGFR/c-METIGF-IRIGF-IIRInsulinandInsulin-likeReceptorInhibitorsInsulinR/CD220INSRRPDGFRalphaPDGFRbetaTie-1Tie-2TrkATrkBTrkCVEGFR1,R2,R3VEGFR1/Flt-1VEGFR2/KDR/Flk-1VEGFR3/Flt-4HER2Market截止到20171218RegionName

NumberofStudiesWorld114

Africa

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2

CentralAmerica

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2

EastAsia

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27

Europe

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46

MiddleEast

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2

NorthAmerica28

Canada

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5

[studies]Mexico1

[studies]UnitedStates

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25

[studies]NorthAsia

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1

Pacifica

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1

SouthAmerica

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1

SouthAsia

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1

SoutheastAsia

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6

s:///ct2/results/map?term=HER2&recrs=m&map=HER2Market截止到20171222BreastNeoplasms1,585SkinDiseases1,503BreastDiseases1,502Carcinoma352NeoplasmsbyHistologicType222Neoplasms,GlandularandEpithelial202GastrointestinalNeoplasms162GastrointestinalDiseases162DigestiveSystemNeoplasms162DigestiveSystemDiseases162TripleNegativeBreastNeoplasms141NeoplasmMetastasis141Adenocarcinoma136StomachNeoplasms115StomachCancer115StomachDiseases105LungNeoplasms88BreastNeoplasms,Male83BreastCancer,Male83NeoplasticProcesses82RespiratoryTractNeoplasms781923Studiesfoundfor:

HER2114Studiesfoundfor:HER2|UnknownstatusStudiesGastricCancerBreastCancerDrug:CyclophosphamideDrug:SargramostimDrug:

HER2-Peptid-VakzineDrug:ImiquimodHER2

PositiveBreastCancerDrug:TucatinibDrug:CapecitabineDrug:TrastuzumabDrug:Placebo