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PPTcoursewareforEnglishversionoftumormetast目录OverviewofTumorMetastasisThemechanismoftubermetastasisDiagnosisandtreatmentoftubermetastasisResearchprogressintubermetathesisCaseanalysisoftubermetathesisOverviewofTumorMetastasis01TumormetastasisreferstothespreadofcancercellsfromtheprimarytubertodistanceorganismsorissuesthroughthebloodstreamorlymphaticsystemDefinitionTumormetathesisisacomplexprocessinvolvingmultiplestepsandfactors,includingtheabilityofcancercellstodetachfromtheprimarytuber,invadingsurroundingissues,enteringthebloodstreamorlymphaticsystem,andestablishingsecondarytutorsatdistancesitesCharacteristicsDefinitionoftubermetathesisEscapefromtheprimarytuberCancercellsbreakawayfromtheprimarytuberandenterthecirculationorlinearsystemCancercellsaretransportedthroughthebloodstreamorlymphaticsystemtodistanceorgansorissuesCancercellsexitthecirculationandinvadesurroundingissueatthesecondarysiteThecancercellssurveyandgrowtoformasecondarytutorTransportationExtravasationGrowthandpromotionTheprocessoftubermetathesisHematogenousmetastasisCancercellsspreadthroughthebloodstreamtodistanceorganismsorissuesInvasionandmetathesisCancercellsinvadelocalissuesandmetathesistoadultorganizationsorissuesLinearmetastasisCancercellsspreadthroughthelinearsystemtolinearnodesorotherorganizationsClassificationoftubermetathesisThemechanismoftubermetastasis02TumorcellsareabnormalcellsthathavelosttheiroriginalfunctionandgainedtheabilitytoinvadesurroundingissuesandmetastasizetootherorganizationsTumorcellsoftenhavestrongresistancetoapoptosisandcanevolveimmunesurveillance,allowingthemtosurviveandgrowinthebodyTumorcellsoftenhavestrongpromotionabilityandcancontinuouslydivideandgrow,leadingtoTumorgrowthThebiologicalcharacteristicsoftumorcellsTumorcellssecretvariableproteolyticenzymestoupgradetheextracellarmatrixandbasementmembrane,allowingtumorcellstoinvadesurroundingissuesTumorcellsexpressadhesionmoleculestoheretoendometrialcellsinbloodvessels,promotingtumorcellmetastasisTumorcellssecretcytokinesandgrowthfactorstopromoteangiogenesisandgenetics,promotingchannelsfortumormetastasisThemolecularmechanismoftubermetastasisTumorcellscanalsoundergoamesenchymalepithelialtransition(MET)toconsolidateatdistancesitesandformmetabolicepisodesTumorcellscanalsointeractwithconventionalcells,suchasfibroblasts,macrophages,andendometrialcells,topromotetumormetastasisTumorcellscanundergoepithelialmesenchymaltransition(EMT)tolosetheirpolarityandcelladhesion,becomingmoremobileandinvasiveThecellularbiologicalmechanismsoftubermetastasisDiagnosisandtreatmentoftubermetastasis03BiopsyForsuspiciousmetastasticlesions,biopsycanbeusedtoconfirmthediagnosisSerummarkersSometubermarkerscanbeusedtodetecttubermetastasis,suchasCEA,CA19-9,andAFPImagingdiagnosticsCT,MRI,ultrasoundandotherimagingtechniquescanbeusedtodetecttumormetastasisDiagnosisoftubermetastasisSurgicaltreatmentForsomemetastatictutors,surgicalrecoverycanbeusedtoremovethemetastaticsectionsChemotherapyChemotherapyisthemaintreatmentformetabolictubers,whichcankilltubercellsandcontroltubergrowthTargetedtherapyTargetedtherapyusesspecificbugstotargetthetubercells,reducingtuberburdenandimprovingpatientsurvivalTreatmentoftubermetastasis010203EarlydetectionandtreatmentEarlydetectionandtreatmentofprimarystudentscanreducetheriskofmetastasisLifestylechangesHealthydie,exerciseandsmokingprocesscanhelpreducetheriskoftumormetabolismGeneticcounselingForindividualswithhighriskgeneticfactors,geneticcounselingcanhelpidentifytheirriskofdevelopingmetabolictubersandtakeappropriatemeasurestopreventandcontrolthediseasePreventionandcontroloftubermetastasisResearchprogressintubermetathesis04ProgressingeneticresearchontubermetathesisResearchmethodsandstrategiesforusinggenetherapytoinhibittumormetastasis.Genetherapyandtumormetastasisstudyingthemutationsofkeygenesduringtumormetastasisandtheirimpactonthemetastaticabilityoftumorcells.GenemutationsandtumormetastasisAnalyzethechangesingeneexpressionduringtumormetastasisandrevealthemolecularmechanismsoftumormetastasis.GeneexpressionandtumormetastasisImmunecellsandtumormetastasisStudytheroleandregulatorymechanismofimmunecellsintheprocessoftumormetastasis.ImmunotherapyandTumorMetastasisExploringmethodsandstrategiesforusingimmunotherapytosuppresstumormetastasis,suchasCAR-Tcelltherapy.ImmunemonitoringandtumormetastasisStudytheapplicationofimmunemonitoringtechnologyinpredictingandevaluatingtheriskoftumormetastasis.Researchprogressinimmunohistochemistryfortubermetastasis010203Targetscreeningandtumormetastasissearchingandverifyingtargetsthatcaninhibittumormetastasis,providingabasisfortargetedtherapy.TargeteddrugsandtumormetastasisResearchondrugdesignandoptimizationtargetingknowntargetstoimprovetheeffectivenessofinhibitingtumormetastasis.DrugresistanceandtumormetastasisExploringthegenerationofdrugresistanceduringtargetedtherapyanditsimpactontumormetastasis,providingstrategiesforovercomingdrugresistance.ResearchprogressintargetedtherapyfortubermetathesisCaseanalysisoftubermetathesis05Case1A52yearoldmanpresentedwithacoughanddyspneaChestCTshowedamassintherightupperlobeofthelung,withmultiplemetastaticlesionsinthebrainandbonesBiopsyconfirmedthediagnosisoflungadenocarcinomawithmetastasisCase2A63yearoldwomanwasfoundtohaveanoduleintheleftlowerlobeofthelungShehasanunderservedmorphologyandpathologyshownmetastaticsquarecellcarcinomaSubsequentstagingworkupreceivedadditionalmetabolicdepositsintheadultlandsandliveCaseanalysisoflungcancertumormetastasisCase3A45yearoldwomanpresentedwithapalebumpinherleftbreastMammographyandbreastultrasoundconfirmedthepresenceofamass,andsheunderstoodaluxuryPathologyshowedinvasiveducalcancerPostoperativestagingworkupretrievedmetabolicdepositsinthedensenodesandbonesCase4A38yearoldwomanwasdiagnosedwithbreastcancerandunderlyingpathologyandaxiallymphnodedissectionShereceivedadvancedchemotherapyandradiationtherapyEighteenmonths
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