侯圣陶博士简介

侯圣陶博士简介现任职务：加拿大国家研究院生物科学研究所脑血管研究组组长职称：加拿大国家研究院生物科学研究所高级研究员渥太华大学（加拿大）兼职教授近期主要研究内容，方向及代表性成果近十年来主要从事神经细胞凋亡机制及基因治疗研究。自1996年起主持10多项包括加拿大国家科学院和加拿大心脏及中风基金会的项目。2000年起参与并主持了加拿大国家科学院的HealthandGenomicsInitiatives项目(二百五十万加元)。研究方向为缺血引起神经细胞凋亡的分子机制和基因治疗。在世界上首次证明转录因子E2F1可调解分化成熟的神经细胞凋亡，E2F1信号传导通路会被许多导致细胞死亡的因素激活，如多巴胺(dopamine),β-amyloid,低钾(lowK+),Fas-受体激活及缺氧和糖处理(oxygen-glucose-deprivation)等。最重要的发现是脑缺血造成的神经组织损伤在E2F1-/-的小鼠上明显小于E2F1+/+。用基因芯片技术，发现几组E2F1的靶基因，理解E2F1靶基因调节神经细胞凋亡的机制对治疗神经变性疾病，如老年痴呆，帕金森氏症，脑中风及青光眼等有非常重要的意义。经过近三年的研究，侯圣陶教授于2005年在国际上首次报道成功构建低氧诱导、神经元特异性腺病毒表达载体p5HRE-3NRSE，该基因治疗载体是研究缺血相关神经变性疾病如脑中风、青光眼的重要工作，并具有潜在的临床应用价值。获得过多项英国和加拿大研究组织奖励和资助，曾多次受邀在国际会议和研究机构宣读论文，在SCI收录的杂志上共发表30篇论文，其中包括J.Neurosci，J.Biol.Chem.，J.Neurochem.等杂志。另外，2项成果申请美国专利。学历1988-1991 Ph.D.(CellBiology),FacultyofMedicine,UniversityofGlasgow,1984-1987 理学硕士,东北师范大学，长春。1980-1984 理学学士,辽宁师范大学，大连。工作经历2005-至今高级研究员(SeniorResearchOfficer),InstituteforBiologicalSciences,NationalResearchCouncilCanada加拿大国家研究院生物科学研究所2002-至今 兼职教授，DepartmentofBiochemistry,UniversityofOttawa,Canada渥太华大学生物化学、免疫及微生物系，加拿大2000-2005 副研究员(AssociateResearchOfficer),InstituteforBiologicalSciences,NationalResearchCouncilCanada加拿大国家研究院生物科学研究所1996-2000 助理研究员(AssistantResearchOfficer),InstituteforBiologicalSciences,NationalResearchCouncilCanada加拿大国家研究院生物科学研究所博士后(ResearchAssociate),DeptofBiochemistry,UniversityofBristol,UK.英国布鲁塞尔大学，生物化学系1991-1993博士后(PostdoctoralResearchFellow),DeptofNeuropathology,InstituteofPsychiatry,UniversityofLondon,UK.英国伦敦大学,神经病理系1988-1991 助教(TeachingAssistant),FacultyofMedicine,UniversityofGlasgow,UK.英国格拉斯哥大学，医学院获奖情况2003-2005BritishCouncil&NRCScienceandTechnologyFund2000TravelAward，国际神经化学年会1995中国人事部客座访问学者PostdoctoralFellowship,英国生物及技术研究委员会(BBSRC),PostdoctoralFellowship,英国医学研究委员会(MRC),GlasgowUniversityResearchStudentScholarship,哥拉斯格大学，PrincipleandVice-chancellor’sOverseasResearchStudentAward，英国大学校长基金会奖参与的国际学术团体FullMember,InternationalSocietyforNeurochemistryFullMember,SocietyforNeuroscience(USA)MemberoftheScientificProgramCommittee,19thInternationalCongressofBiochemistryandMolecularBiology,Toronto(CANADA)20-25July2003MemberoftheNSERC(Canada)Committee(responsibleforreviewinggrantapplications)指导研究生情况亲自和参与指导了6名博士后，多名博士，硕士生以及本科生的毕业论文工作。近年代表著作如下（累计：IF130多分）

PublishedandSubmittedRefereedPapersinthelast5years(*indicatescorrespondingauthor)HouST*,KeklikianA,SlinnJ,O'HareM,JiangSX,AylsworthA.(2008)Sustainedup-regulationofsemaphorin3A,Neuropilin1,anddoublecortinexpressioninischemicmousebrainduringlong-termrecovery.BiochemBiophysResCommun.367:109-15.IF:2.749RyanSD,HarrisCS,MoF,LeeH,HouST,BazanNG,HaddadPS,ArnasonJT,BennettSA.(2007)Plateletactivatingfactor-inducedneuronalapoptosisisinitiatedindependentlyofitsG-proteincoupledPAFreceptorandisinhibitedbythebenzoateorsellinicacid.JNeurochem.103:88-97.IF:4.451JiangSX,KapplerJ,ZurakowskiB,DesboisA,AylsworthA,HouST*.(2007)Calpaincleavageofcollapsinresponsemediatorproteinsinischemicmousebrain.EurJNeurosci.26:801-9.IF:3.673DuftyBM,WarnerLR,HouST*,JiangSX,Gomez-IslaT,LeenhoutsKM,OxfordJT,FeanyMB,MasliahE,RohnTT.(2007)Calpain-cleavageofalpha-synuclein:connectingproteolyticprocessingtodisease-linkedaggregation.AmJPathol.170:1725-38.HouST*,JiangSX,HuangD,DesboisA.(2007)Anoveladenoviralvector-mediatedneuronalselectivegeneexpressioninneonatalmousebraininresponsetohypoxia.NeurosciLett.419:23-7.IF:2.085JiangSX,SheldrickM,DesboisA,SlinnJ,HouST*.(2007)Neuropilin-1isadirecttargetofthetranscriptionfactorE2F1duringcerebralischemia-inducedneuronaldeathinvivo.MolCellBiol.27:1696-705.IF:6.42Hou,ST*,JiangSX,DesboisD,HuangDQ,KellyJ,TessierL,KarchewskiL,KapplerJ(2006)Calpain-CleavedCollapsinResponseMediatorProtein-3InducesNeuronalDeathafterGlutamateToxicityandCerebralIschemia.JNeurosci26(8)1-9.IF:7.49JiangSX,LertvorachonJ,HouST*,KonishiY,WebsterJ,MealingG,BrunetteE,TauskelaJ,PrestonE.(2005)Chlortetracyclineanddemeclocyclineprotectmouseneuronsagasintglutamatetoxicityandcerebralischemiathroughinhibitionofcalpain.JBC280:33811-33818.IF:5.581WeaverJGR,TarzeA,MoffatTC,LeBrasM,DeniaudA,BrennerC,BrenGD,MorinMY,PhenixBN,MillerB,DongL,JiangSX,SimVL,ZurakowskiB,LallierJ,HardinH,WettsteinP,vanHeeswijkRPG,DouenA,KroemerR,HouST,BennettSAL,LynchDH,KroemerG,BadleyAD.(2005)InhibitionofAdenineNucleotideTranslocatorPoreFunctionandProtectionAgainstApoptosisinvivobyanHIVProteaseInhibitor.JClinicalInvestigation115:1828-1838.(Iwasresponsibleformousestrokeworkperformedinthisstudy).IF:16.915Huang,D.,Desbois,A.andHou,ST*(2005)Anoveladenoviralvectorwhichmediateshypoxia-induciblegeneexpressionselectivelyinneurons.GeneTherapy12:1369-1376.IF:4.812LortieK,HuangD,ChakravarthyB,ComasT,HouST,Lin-ChaoS,MorleyP(2005)Thegas7proteinpotentiatesNGF-mediateddifferentiationofPC12cells.BrainRes1036:27-34.IF:2.218LinYP,DesboisA,JiangS,HouST*(2005)P2receptorantagonistPPADSconfersneuroprotectionagainstglutamate/NMDAtoxicity.NeurosciLett.377:97-100.IF:2.085LinYP,DesboisA,JiangS,HouST*(2004)GroupBvitaminsprotectmurinecerebellargranulecellsfromglutamate/NMDAtoxicity.NeuroReport24,2241-2244.IF:2.163Hou,ST*,DoveM.,AndersonE.,ZhangJB.,MacKenzieCR(2004)Identificationofpolypeptideswithselectiveaffinitytointactmousecerebellargranuleneuronsfromarandompeptide-presentingphagelibrary.J.NeurosciMethods138,39-44.IF:1.884Huang,D.Q.,Walker,T.,DesboisA.,Collier,C.L.,ChartierJ.,ChenG.,DoveM.,Fang,H.,HouST*.(2004)Expressionofcoxsakie-adenovirusreceptorandintegrins3/5onhumanNT2neurons:thelackofintegrin3expressionmaylimittheefficiencyofadenovirus-mediatedgenetransfer.JMolNeurosci24,323-328.IF:1.735Smith,R.A.,Walker,T.,andHou,ST*(2003)InvolvementofthetranscriptionfactorE2F1/Rbinkainicacid-induceddeathofcerebellargranulecells.MolBrainRes.116,70-79.IF:1.997Hou,ST*,Becker,K.G.,Baggley,A.,Chen,G.,andWebster,J.(2003)High-densityDNAmicroarrayanalysisofgeneexpressionfollowingtransientfocalcerebralischemiainmouse.ExcerptaMedicaVol1736,1-12.Smith,R.A.,Walker,T.,Hou,ST*(2003):Adenosinereceptorligandsfailtoattenuatekainicacid-induceddeathofculturedmousecerebellarneurons.Ann.Anat.185,326-327.IF:0.817Hou,ST*.Xie,X.,Baggley,A.,Park,D.S.,Chen,G.,andWalker,T.(2002)ActivationoftheRb/E2F1pathwaybythenon-proliferativep38MAPkinaseduringFas(APO1/CD95)-mediatedneuronalapoptosis.JBiolChem.277,48764-48770.IF:5.581Hou,ST*.andMaManus,J.P.(2002)Molecularmechanismsofneuronaldeath-inducedbycerebralischemia.IntRevCytol.221,93-148.IF:5.506Hou,ST*,Cowan,E.,Walker,T.,Ohan,N.,Dove,M.,Rasqinha,I.,andMacManus,J.P.(2001)ThetranscriptionfactorE2F1promotesdopamine-evokedneuronalapoptosisbyamechanismindependentoftranscriptionalactivation.JNeurochem.78:287-297.IF:4.451Hou,ST*,Cowan,E.,Dostanic,S.,Rasquinha,I.,Comas,T.,Morley,P.,andMacManus,J.P.(2001)IncreasedexpressionofE2F1duringdopamine-evokedcaspase-3-mediatedapoptosisinratcorticalneurons.NeurosciLett.306:153-6.IF:2.085Gendron,T.F.,Mealing,G.A.,Paris,J.,Lou,A.,Edwards,A.,Hou,ST.,MacManus,J.P.,Hakim,A.M.,Morley,P.(2001)AttenuationofneurotoxicityincorticalculturesandhippocampalslicesfromE2F1knockoutmice.JNeurochem.78:316-324.IF:4.451Hou,ST*,Callaghan,D.,Fournier,M.C.,Hill,I.,Kang,L.,Massie,B.,Morley,P.,Murray,C.,Rasquinha,I.,Slack,R.,MacManus,J.P.(2000)ThetranscriptionfactorE2F1modulatesapoptosisofneurons.JNeurochem.75:91-100,IF:4.451O'Hare,M.J.,Hou,ST.,Morris,E.J.,Cregan,S.P.,Xu,Q.,Slack,R.S.,Park,D.S.(2000)InductionandmodulationofcerebellargranuleneurondeathbyE2F-1.JBiolChem.275:25358-64.IF:5.581Giovanni,A.,Keramaris,E.,Morris,E.J.,Hou,ST.,O'Hare,M.,Dyson,N.,Robertson,G.S.,Slack,R.S.,Park,D.S.(2000)E2F1mediatesdeathofB-amyloid-treatedcorticalneuronsinamannerindependentofp53anddependentonBaxandcaspase3.JBiolChem.275:11553-60.IF:5.581PublishedBooksandMonographs(asauthororeditor)HouSt*andSmithRA(2008)Decipheringthecuesandsignallingpathwaysofaxonalgrowthandregeneration.IntlRevCell&MolBiol(inpress)O’hare,M,andHou,ST*(2008)ThetranscriptionfactorE2Finneuronaldeath.ResearchSignpostpp.123-133.Hou,S.T.*,Becker,K.G.,Baggley,A.,Chen,G.,andWebster,J.(2003)High-densityDNAmicroarrayanalysisofgeneexpressionfollowingtransientfocalcerebralischemiainmouse.ExcerptaMedicaInternationalCongressSeriesVol1736,1-12.ElsevierScienceHou,S.T.(2001)Dissectinghumanneurodegenerativediseasesinthepostgenomicsera.APECTechnomartIVS&TForumpp83-97.MacManus,J.P.,Hou,S.T.,Jian,M.,Webster,J.,andZurakowski,B.(2000)AroleforthetranscriptionfactorE2F1inexperimentalstrokedamage.InPharmacologyofCerebralIschemia(J.KrieglsteinEd.),pp.17-25.MedpharmScientificPublishers,StuttgartPublishedAbstracts/NumberofNotes(includenameofjournal，titleofarticleanddatesubmitted)Hou,S.T,Jiang,S.X,Sheldrick,M,Desbois,A.(2005)Neuropilin-1isamoleculartargetofthetranscriptionfactorE2F1andisinvolvedincerebralischemia-inducedneuronaldeath.JCerebBloodFlowMetab(Brain05)S71.HuangD,DesboisA,andHouST(2004)Anoveladenoviralve