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一、消化的意义·
二、消化系统At
its
simplest,
the
digestive
system
it
is
a
tube
runningfrom
mouth
to
anus.
This
tube
is
like
an
assembly
line,
ormore
properly,
a
dissembly
line.
Its
chief
goal
is
to
breakdown
huge
macromolecules
(proteins,
fats
and
starch),
whichcannot
be
absorbed
intact,
into
smaller
molecules
(amino
acidfatty
acids
and
glucose)
that
can
be
absorbed
across
the
wallof
the
tube,
and
into
the
circulatory
system
for
disseminationaround
your
body.The
breakdown
of
foodstuffs
like
a
Big
Mac
is
accomplished
through
a
combination
of
mechanical
and
enzymatic
processes.
Toaccomplish
this
breakdown,
the
digestive
tube
requires
considerableassistance
from
accessory
digestive
organs
such
as
the
salivaryglands,
liver
and
pancreas,
which
dumptheirsecretions
into
the
tube.The
name
"accessory"
should
not
be
taken
to
mean
dispensible;indeed,
without
pancreatic
enzymes
you
would
starve
to
death
inshort
order.In
many
ways,
the
digestive
system
can
be
thought
of
as
a
well-runfactory
in
which
a
large
number
of
complex
tasks
are
performed.
Thethree
fundamental
processes
that
take
place
are:Secretion:
Delivery
of
enzymes,
mucus,
ions
and
the
like
into
thelumen,
and
hormones
into
bloodAbsorption:
Transport
of
water,
ions
and
nutrients
from
the
lumen,across
the
epithelium
and
into
bloodMotility:
Contractions
of
smooth
muscle
in
the
wall
of
the
tube
thatcrush,
mix
and
propel
its
contents三、口腔内消化四、胃内消化(一)胃运动胃容受性舒张(receptive
relaxation)胃蠕动peristalsis胃排空
(gastric
empty)(二)胃液成分和作用盐酸胃蛋白酶黏液内因子Gastric
function
is
often
classified
into
three
phases
in
whichsecretory
anactivities
are
tightly
coupled.
Try
identifying
these
phases
in
yourself
orones
around
meal
time:Cephalic
phase
("wake
up
call"):
Seeing,smelling
and
anticipating
food
in
perceived
inthe
brain
and
the
brain
informs
the
stomachthat
it
shouldprepare
for
receipt
of
a
meal.This
communication
is
composed
ofparasympathetic
stimuli
transmitted
thoughtthe
vagus
nerve
to
the
enteric
nervous
system,resulting
in
releaseofacetylcholine
in
thevicinity
of
G
cells
and
parietal
cells.Binding
ofacetylcholine
to
its
receptor
on
G
cells
inducessecretion
of
the
hormone
gastrin,
which,
inconcertwithacetylcholine
and
histamine,stimulates
parietal
cells
to
secrete
smallamounts
of
acid.
Additionally,a
low
level
ofgastric
motility
is
induced.
In
essense,
thegastric
motor
is
turned
on
andbeginsto
idle.Gastric
phase
("full
steam
ahead"):
When
a
meal
entersthe
stomach
several
additional
factors
come
into
playforemost
among
them
distension
and
mucosal
irritationDistension
excites
stretch
receptors
and
irritationactivates
chemoreceptors
in
the
mucosa.
These
eventssensed
by
enteric
neurons,which
secrete
additionalacetylcholine,
further
stimulating
both
G
cells
andparietal
cells;
gastrin
from
the
G
cells
feeds
back
toparietal
cells,
stimulating
it
even
further.
Additionactivation
of
the
enteric
nervous
system
and
release
ogastrin
cause
vigorous
smooth
muscle
contractions.
Thnet
result
is
that
secretory
and
motor
functions
of
thstomach
are
fully
turned
on
-
lots
of
acid
and
pepsinogare
secreted,
pepsinogen
is
converted
into
pepsin
andvigorous
grinding
and
mixing
contractions
take
place.However,
there
is
a
mechanism
in
place
in
the
stomach
tprevent
excessive
acid
secretion
-
if
lumenal
pH
dropsenough
(less
than
about
2),
motility
and
secretion
aretemporarily
suspended.Intestinal
phase
("step
on
the
brakes"):
Asfood
is
liquefied
inthe
stomach,
it
is
emptiedinto
the
small
intestine.
Its
seemsto
beimportant
for
the
small
intestine
to
beable
toslow
down
gastric
emptying,
probablytoallow
it
time
to
neutralize
the
acid
andefficiently
absorb
incoming
nutrients.Hence,
this
phase
of
gastric
function
isdominated
by
the
small
intestine
sendinginhibitory
signals
to
the
stomachto
slowsecretion
and
motility.
Two
types
of
signalsare
used:
nervous
and
endocrine.
Distensionof
the
small
intestine,
as
well
as
chemicaland
osmotic
irritation
of
themucosa
istransduced
into
gastric-inhibitoryimpulsesin
the
enteric
nervous
system
-
thisnervouspathway
is
called
the
enterogastric
reflex.Secondly,
enteric
hormones
such
ascholecystokinin
and
secretin
are
released
from
cells
in
the
small
intestineandcontribute
to
suppression
of
gastric
activity.五、小肠的消化(一)运动形式紧张性收缩分节运动蠕动二、小肠内化学性消化(一)胆汁的成分、作用水无机盐:Na
K
Ca
HCO-。中和一部分盐酸有机成分:胆汁酸+甘氨酸、牛黄酸+
Na+
K+→胆盐胆色素:胆红素→胆绿质胆固醇:肝合成卵磷脂:比例适就应溶解态/沉积、胆石胆盐、胆固醇、卵磷脂,作为乳化剂微滴3000-10000nm脂肪的消化和吸收 一定浓度胆盐→微胶粒(水溶性)进而促进脂溶性Vit
A
D
E
K的吸收肝脏的机能:500种以上的主要有糖代谢:血糖稳定中心作用,肝糖元占肝重5%-6%蛋白质、脂肪代谢:合成血浆蛋白、防解氨成尿素。
Aa互变,蛋白质→脂肪分泌胆汁:人800-1000ml/d其中胆达1.1g%缺乏食入脂肪40%
不能消化吸收解毒酒精代谢激素失活贮存作用胰岛素T
T3(T4)
消除抗原。甘油酯
VB12
用几年Food
is
processed
in
the
digestive
tract
in
a
very
organizedmanner.
The
mouth
is
responsible
for
moistening
and
physicalbreakdown
of
the
food.
Very
little
enzymatic
digestion
occurs
herThe
highly
acidic
(hydrochloric
acid)
stomach
has
a
number
offunctions,
including
physical
breakdown
of
food,
food
storage,killing
microorganisms,
and
initial
protein
digestion.
The
smallintestine
is
where
most
food
digestion
occurs
includingcarbohydrate,
fat,
and
protein.
Entry
of
acidic
stomach
fluids(=chyme)
into
the
small
intestine
cause
the
release
of
pancreaticjuices.
These
basic
jui
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