Nitrocaramiphen-hydrochloride-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENitrocaramiphenhydrochlorideCat.No.:HY-100945CASNo.:98636-73-8分⼦式:C₁₈H₂₇ClN₂O₄分⼦量:370.87作⽤靶点:mAChR作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验H2O:8.33mg/mL(22.46mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.6964mL13.4818mL26.9636mL5mM0.5393mL2.6964mL5.3927mL10mM0.2696mL1.3482mL2.6964mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性NitrocaramiphenHydrochloride⼀种选择性M1受体拮抗剂(Ki:5.5nM)。NitrocaramiphenHydrochloride抑制肌纤维中毒蕈碱的超极化作⽤。IC50&TargetKi:5.5nM(M1receptor)[2]REFERENCES1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[1].HussainRI,etal.Activationofmuscarinicreceptorselicitsinotropicresponsesinventricularmusclefromratswithheartfailurethroughmyosinlightchainphosphorylation.BrJPharmacol.2009Feb;156(4):575-86.[2].HudkinsRL,etal.Caramiphen,iodocaramiphenandnitrocaramiphenarepotent,competitive,muscarinicM1receptor-selectiveagents.EurJPharmacol.1993Feb16;231(3):485-8.[3].NaumenkoNV,etal.[Pharmacologicalparametersofmuscariniccholinoreceptorsinskeletalmuscles].RossFiziolZhImIMSechenova.2002May;88(5):619-26.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955