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pH敏感双亲性聚合物的研究进展pH敏感双亲性聚合物的研究进展#[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]GalaevIY,MattiassonB.TrendsBiotechnol.,1999,17:335〜340.LiuQQ,YuZQ,NiPH.ColloidPolym.Sci.,2004,282(4):387〜393.E.S.Lee,K.NaandY.H.Bae.J.ControlledRelease,2003,91,103〜113.E.S.Lee,K.NaandY.H.Bae.NanoLett.,2005,5,325〜329.E.S.Lee,K.NaandY.H.Bae.J.ControlledRelease,2005,103,405〜418.A.S.Lee,A.P.Gast,V.Butun,S.P.Armes.CharacterizingtheStructureofpHDependentPolyelectrolyteBlockCopolymerMicelles[J].Macromolecules,1999,32(13):4302〜4310.V.Butun,S.P.Armes,N.C.Billingham,atel.TheRemarkable"Flip-Flop"Self-AssemblyofaDiblockCopolymerinAqueousSolution[J].Macromolecules,2001,34(5):1503〜1511.A.S.Lee,V.Butun,S.P.Armes,atel.StructureofpH-DependentBlockCopolymerMicelles:ChargeandIonicStrengthDependence[J].Macromolecules,2002,35(22):8540〜8551.S.Liu,J.V.M.Weaver,S.P.Armes,atel.SynthesisofShellCross-LinkedMicelleswithpH-ResponsiveCoresUsingABCTriblockCopolymers[J].Macromolecules,2002,35(16):6121〜6131.Dai,S.;Ravi,P.;Tam,K.C.Langmuir,2003,19,5175.GilliesER,FrechetJMJ.ChemCommun,2003,1640~1641.GilliesER,JonssonTB,FrechetJMJ.JAmChemSoc,2004,126:11936~11943.GilliesER,FrechetJMJ.BioconjugateChem,2005,16:361~368.黄潇楠,杜福胜,杨俊等•含环状原酸酯侧基的两亲性嵌段共聚物及其酸敏感胶束状聚集体[J].高分子学报,2009,1:88〜92LIHong-xia,ZHANGCan,YOUQi-dong.Synthesis,characterizationandpHsensitivityofN-octyl-N'-imino-O-carboxym-ethylchitosanderivatives[J].JournalofChinaPharmaceuticalUniversity,2009,40(5):385〜388JingFungTan,AntonBlencowe,TorKitGoh,atel.AGeneralMethodfortheSynthesisandIsolationofWell-DefinedCoreCross-LinkedMultistarAssemblies:ARoutetowardEnhancepH-ResponsivePoly-mers[J].Macromolecules,2009,42,4622〜4631.ChristineM.Schilli,MingfuZhang,EzioRizzardo,atel.ANewDouble-ResponsiveBlockCopolymerSynthesizedviaRAFTPolymerization:Poly(N-isopropylacrylamide)-block-poly(acrylicacid)[J].Macromolecules,2004,37,7861〜7866.JianHZ,LiW,JianZM,atel.Temperature-andpH-responsivestaramphiphilicblockcopolymerpreparedbyacombiningstrategyofring-openingpolymerizationandreversibleaddition-ragmentationtransferpolymerization[J].EuropeanPolymerJournal,2010,46:1288〜1298.HUNTCA,MACGREGORRD,SIEGALRA.EngineeringtargetedinvivodrugdeliveryI.Thephysiolog-ical&physicochemicalprinciplesgoverningopportunities&limitations[J],PharmRes,1986,3(12):333〜

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