Procaterol-hydrochloride-hemihydrate-OPC-2009-hydrochloride-hemihydrate-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEProcaterolhydrochloridehemihydrateCat.No.:HY-129041CASNo.:81262-93-3Synonyms:OPC2009hydrochloridehemihydrate分⼦式:C₁₆H₂₃ClN₂O₃.₁/₂H₂O分⼦量:335.82作⽤靶点:AdrenergicReceptor作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验H2O:25mg/mL(74.44mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.9778mL14.8889mL29.7779mL5mM0.5956mL2.9778mL5.9556mL10mM0.2978mL1.4889mL2.9778mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Procaterolhydrochloridehemihydrate⼀种具有⼝服活性的β2肾上腺素受体(β2adrenoreceptor)激动剂。Procaterolhydrochloridehemihydrate可⽤于哮喘研究。体外研究Procaterolhydrochloridehemihydrate(0.1μM,24-72h)decreasesrhinovirusinfectioninhumantrachealepithelialcells[4].1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEProcaterolhydrochloridehemihydrate(0-1μg/mL,24/48h)inhibitsIL-1β-andTNF-α-mediatedeosinophilchemotacticactivityinBEAS-2Bcell[5].procaterolhydrochloridehemihydrate(25-200nM,20h)protects16HBEcellsfromH2O2-inducedoxidativestress[6].体内研究Procaterolhydrochloridehemihydrate(1,3or10μg/mL,inhaledadministration)inhibitshistamine-inducedairflowobstructionandmicrovascularleakageinguinea-pigairwayswithallergicinflammation[2].Procaterolhydrochloridehemihydrate(0.1mg/kg,i.p.)completelyabolishesboththeMch-inducedcoughinconsciousguineapigs[3].AnimalModel:Allergicinflammatoryguinea-pigmodel[2]Dosage:1,3or10μg/mLAdministration:InhaledadministrationResult:Inhibitedhistamine-inducedairflowobstructionandmicrovascularleakage.户使⽤本产品发表的科研⽂献•JPharmaceutBiomed.2020,113870.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].TukiainenH,etal.Comparisonbetweenoralprocaterolandsalbutamolinpatientswithbronchialasthma.CurrMedResOpin.1988;11(4):236-41.[2].MirzaZN,etal.Inhaledprocaterolinhibitshistamine-inducedairflowobstructionandmicrovascularleakageinguinea-pigairwayswithallergicinflammation.ClinExpAllergy.1998May;28(5):644-52.[3].OhkuraN,etal.Bronchoconstriction-triggeredcoughinconsciousguineapigs.ExpLungRes.2009May;35(4):296-306.[4].YamayaM,etal.Procaterolinhibitsrhinovirusinfectioninprimaryculturesofhumantrachealepithelialcells.EurJPharmacol.2011Jan10;650(1):431-44.[5].KoyamaS,etal.ProcaterolinhibitsIL-1beta-andTNF-alpha-mediatedepithelialcelleosinophilchemotacticactivity.EurRespirJ.1999Oct;14(4):767-75.[6].DengZ,etal.Procaterolbutnotdexamethasoneprotects16HBEcellsfromH₂O₂-inducedoxidativestress.JPharmacolSci.2014;125(1):39-50.McePdfHeightCaution:Producthasnotbeenfullyvalidatedfor