SIRT2-IN-9-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESIRT2-IN-9Cat.No.:HY-151519CASNo.:522650-91-5分⼦式:C₂₁H₂₂N₆OS₂分⼦量:438.57作⽤靶点:Sirtuin作⽤通路:CellCycle/DNADamage;Epigenetics储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:4.46mg/mL(10.17mM;ultrasonicandwarmingandheatto70°C)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.2801mL11.4007mL22.8014mL5mM0.4560mL2.2801mL4.5603mL10mM0.2280mL1.1401mL2.2801mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性SIRT2-IN-9(compound12)SRIT2的选择性抑制剂，IC50值为1.3μM。SIRT2-IN-9抑制MCF-7乳腺癌细胞的增殖活性。SIRT2-IN-9可⽤于癌症的研究。IC50&TargetSIRT2SIRT1SIRT31.3μM(IC50)＞300μM(IC50)＞300μM(IC50)体外研究SIRT2-IN-9(1-100μM;15min)dose-dependentlyinhibitsSRIT2withanIC50valueof1.3μM,andinhibits1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESRIT1andSRIT3withIC50s＞300μM[1].SIRT2-IN-9(0-50μM;72h)affectscellviabilityofMCF-7cells[1].SIRT2-IN-9(0-50μM;6h)affectsacetylationofα-tubulinprotein[1].CellProliferationAssay[1]CellLine:MCF-7breastcancercelllineConcentration:0-50μMIncubationTime:72hoursResult:Dose-dependentlyinhibitedcellproliferationofMCF-7breastcancercells.WesternBlotAnalysis[1]CellLine:MCF-7breastcancercelllineConcentration:6.25,12.5,25and50μMIncubationTime:6hoursResult:Dose-dependentlyincreasedacetylationofα-tubulinprotein.REFERENCES[1].YangSY,LiLL.Thepurposesof5H-[1,2,4]triazine[5,6-b]indolederivativesof3substitutions.CN108309982A.2017.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792